A5051366864- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Caveolin-1 and cellular processes
- Neuroscience and Neural Engineering
- Cell death mechanisms and regulation
- Hippo pathway signaling and YAP/TAZ
- Cardiac Fibrosis and Remodeling
- Neural dynamics and brain function
- Protease and Inhibitor Mechanisms
- Bioinformatics and Genomic Networks
- Protein Kinase Regulation and GTPase Signaling
- Signaling Pathways in Disease
- stochastic dynamics and bifurcation
- Lipoproteins and Cardiovascular Health
- Atherosclerosis and Cardiovascular Diseases
- Photoreceptor and optogenetics research
- Ubiquitin and proteasome pathways
University at Buffalo, State University of New York
2020-2025
ABSTRACT Cell cycle control is a key aspect of numerous physiological and pathological processes. The contribution biophysical cues, such as stiffness or elasticity the underlying extracellular matrix (ECM), critically important in regulating cell progression proliferation. Indeed, increased ECM causes aberrant However, molecular mechanisms that these stiffness-mediated cellular responses remain unclear. Here, we address this gap show good evidence lamellipodin (symbol RAPH1), previously...
Vascular dysfunction is a common cause of cardiovascular diseases characterized by the narrowing and stiffening arteries, such as atherosclerosis, restenosis, hypertension. Arterial results from aberrant proliferation vascular smooth muscle cells (VSMCs) their increased synthesis deposition extracellular matrix (ECM) proteins. These, in turn, are modulated arterial stiffness, but mechanism for this not fully understood. We found that survivin an important regulator stiffness-mediated ECM...
Stiffened arteries are a pathology of atherosclerosis, hypertension, and coronary artery disease key risk factor for cardiovascular events. The increased stiffness triggers phenotypic switch, hypermigration, hyperproliferation vascular smooth muscle cells (VSMCs), leading to neointimal hyperplasia accelerated neointima formation. However, the mechanism underlying this trigger remains unknown. Our analyses whole-transcriptome microarray data from mouse VSMCs cultured on stiff hydrogels...
ABSTRACT Cardiovascular diseases (CVDs) and pathologies are often driven by changes in molecular signaling communication, as well cellular tissue components, particularly those involving the extracellular matrix (ECM), cytoskeleton, immune response. The fine-wire vascular injury model is commonly used to study neointimal hyperplasia vessel stiffening, but it not typically considered a for CVDs. In this paper, we hypothesize that induces gene expression, biological processes similar observed...
Cellular metabolism is influenced by the stiffness of extracellular matrix. Focal adhesion kinase (FAK) and its binding partner, p130Cas, transmit biomechanical signals, such as substrate stiffness, to cell regulate a variety cellular responses, but their roles in early transcriptional metabolic responses remain largely unexplored. We cultured mouse embryonic fibroblasts with or without siRNA-mediated FAK p130Cas knockdown assessed these cells placement on soft stiff substrates RNA...
The physiological origin of the aperiodic signal present in electrophysiological recordings, called l/f neural noise, is unknown; nevertheless, it has been associated with health and disease. power spectrum slope, <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$-\alpha$</tex> xmlns:xlink="http://www.w3.org/1999/xlink">$1/\mathrm{f}^{\alpha}$</tex> , postulated to be related dynamic balance between excitation (E) inhibition (I). Our study found...
Abstract The physiological origin of the aperiodic signal present in electrophysiological recordings, called 1/f neural noise, is unknown; nevertheless, it has been associated with health and disease. power spectrum slope, -a a , postulated to be related dynamic balance between excitation (E) inhibition (I). Our study found that human cerebral organoids grown from induced pluripotent stem cells (iPSCs) Schizophrenia patients (SCZ) showed structural changes altered elasticity compared normal...
SUMMARY Stiffened arteries are a pathology of atherosclerosis, hypertension, and coronary artery disease key risk factor for cardiovascular events. The increased stiffness triggers the hypermigration hyperproliferation vascular smooth muscle cells (VSMCs), leading to neointimal hyperplasia accelerated neointima formation, but mechanism this trigger is not known. Our analyses whole-transcriptome microarray data sets from mouse VSMCs cultured on stiff hydrogels simulating arterial injured...