A5110255925- Numerical methods in inverse problems
- Advanced Optimization Algorithms Research
- Iterative Methods for Nonlinear Equations
- Diabetes Management and Research
- Geophysical Methods and Applications
- Diabetes and associated disorders
- Peer-to-Peer Network Technologies
- Pancreatic function and diabetes
- Parallel Computing and Optimization Techniques
- Geophysical and Geoelectrical Methods
- Statistical and numerical algorithms
- Electrical and Bioimpedance Tomography
- Image and Video Quality Assessment
- Distributed and Parallel Computing Systems
- Seismic Imaging and Inversion Techniques
- Advanced Vision and Imaging
- Information Technology Governance and Strategy
- Advanced Fiber Optic Sensors
- Metal Forming Simulation Techniques
- Robotics and Sensor-Based Localization
- Advanced Control Systems Optimization
- Numerical Methods and Algorithms
- Mechanical and Thermal Properties Analysis
- Heat Transfer and Mathematical Modeling
- Opportunistic and Delay-Tolerant Networks
RISE Research Institutes of Sweden
2020-2022
Umeå University
1995-2021
Computing Center
2021
AstraZeneca (Sweden)
2019
Abstract Aims To investigate dysregulation of the autonomic nervous system as a potential mechanism for early insulin resistance in development Type 2 diabetes. Methods Thirteen healthy individuals with first‐degree relatives diabetes (R) were compared 14 control subjects without family history (C), matched age, body mass index and sex. An oral glucose tolerance test hyperinsulinaemic euglycaemic clamp performed. Analysis heart rate variability during rest, controlled breathing, an...
Sex chromosomes shape male (XY) - female (XX) differences in development and disease. These can be modelled vitro by comparing XY XX human induced pluripotent stem cells (hiPSCs). However, this system, inter-individual autosomal variation unstable X-dosage compensation confound identification of sex chromosomal effects. Here, we utilise chromosome loss XXY fibroblasts to generate hiPSCs that are autosomally isogenic exhibit stable compensation. We also create X-monosomic (XO) hiPSCs,...
To identify clinical, immunological and biochemical factors that predict remission, its duration in a large cohort of young adults with Type 1 diabetes mellitus (DM).In Sweden, 362 patients (15-34 years), classified as DM were included prospective, nation-wide population-based study. All followed at local hospitals for examination HbA(1c) insulin dosage over median period after diagnosis 5 years. Duration defined an maintenance dose </= 0.3 U/kg/24 h within the normal range, was analysed...
Paracrine factors can induce cardiac regeneration and repair post myocardial infarction by stimulating proliferation of cells inducing the anti-fibrotic, antiapoptotic, immunomodulatory effects angiogenesis. Here, we screened a human secretome library, consisting 923 growth factors, cytokines, proteins with unknown function, in phenotypic screen progenitor cells. The primary readout was measured nuclear count. From this screen, identified FGF1, FGF4, FGF9, FGF16, FGF18, seven additional that...
Screen printed piezoelectric polyvinylidene fluoride–trifluoro ethylene (PVDF–TrFE)‐based sensors laminated between glass panes in the temperature range 80–110 °C are presented. No degradation of signals is observed for at 110 °C, despite approaching Curie material. The sensors, here monitoring force impact smart applications, characterized by using a calibrated hammer system and standardized situations. Stand‐alone integrated on poly(methyl methacrylate) also evaluated. constants obtained...
Glass structures have been increasingly utilised in modern construction for decades with load-bearing walls or facades as the most common elements. However, use of glass beams has recently given more attention but its application elements limited by low tensile resistance, brittle behaviour during failure and concerns performance case fire. Parts these aspects can be covered using Timber-Glass composites beams, timber flanges a web. Previous research practical show high potential this type...
In fluorescence optical tomography, many works in the literature focus on linear reconstruction problem to obtain fluorescent yield or linearized absorption coefficient. The nonlinear problem, reconstruct fluorophore coefficient, is of interest imaging studies as it presents possibility better reconstructions owing a more appropriate model. Accurate and computationally efficient forward models are also critical process. approximation radiative transfer equation (RTE) gaining importance for...
In a reconstruction problem for subsurface tomography (modeled by the Helmholtz equation), we formulate novel scheme shape and electromagnetic parameters from scattered field data, based upon an implicit Hermite interpolation radial basis function (RBF) representation of boundary curve. An object's is defined implicitly as zero level set RBF fitted to comprising locations few points on curve (the centers) normal vectors at those points. The parameter reconstructed normalized (w.r.t. squared...
A nonlinear Helmholtz-equation-modeled electromagnetic tomographic reconstruction problem is solved for the object boundary and inhomogeneity parameters in a damped Tikhonov-regularized Gauss-Newton (DTRGN) solution framework. In this paper, represented suitable global basis, whereas expressed as zero level set of signed-distance function. For an explicit parameterized boundary-representation-based scheme, analytical Jacobian Hessian calculations are made to express changes scattered field...
We address numerical optimization algorithms for solving nonlinear least squares problems that lack well-defined solutions, in particular discrete parameter estimation problems. present based on the Gauss–Newton method both exactly and almost rank-deficient Merit functions proposed have good global convergence properties. Numerical results confirm local are presented.
The dynamic reconstruction problem in tomographic imaging is encountered several applications, such as species determination, the study of blood flow through arteries/veins, motion compensation medical imaging, and process tomography. method choice Kalman filter its variants, which, however, are faced by issues tuning. In addition, since time-propagation models physical parameters typically very complex, most time, a random walk model considered. For geometric deformations, affine used. our...
ObjectiveTo investigate whether measurements of proinsulin and/or intermediate degradation products could be used to differentiate between autoimmune (type 1) and non‐autoimmune 2) diabetes in young adults. Material methods Total proinsulin, intact 32,33 split concentrations were measured 25 patients aged 15–34 years with type 1 diabetes, as defined by the presence at least two positive islet autoantibodies, 23 antibody‐negative similar age 2 time clinical onset 3–4 months thereafter....
A nonlinear least squares problem with constraints may be ill posed or even rank-deficient in two ways. Considering the formulated as <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="min Underscript x Endscripts 1 slash 2 double-vertical-bar f left-parenthesis right-parenthesis Subscript Superscript 2"> <mml:semantics> <mml:mrow> <mml:munder> <mml:mo movablelimits="true" form="prefix">min</mml:mo> <mml:mrow class="MJX-TeXAtom-ORD">...
Abstract Compared to unicast traffic, multicast is not protected by any ARQ mechanism in 802.11 networks: collisions with other and transmissions are detected senders will adapt the contention situation backing off. This results an unreliable service for transmissions. We propose early collision detection (EMCD), algorithm purpose of increasing reliability MAC layer IEEE network. A sender using it introduce pause a transmission, perform clear channel assessment (CCA), if abort transmission...