A5101996853- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Adipose Tissue and Metabolism
- Atrial Fibrillation Management and Outcomes
- Immune Response and Inflammation
- Advanced Proteomics Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Congenital heart defects research
- Antimicrobial Peptides and Activities
- Chemical Synthesis and Analysis
- RNA modifications and cancer
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- Diet and metabolism studies
- NF-κB Signaling Pathways
- Pharmacogenetics and Drug Metabolism
- stochastic dynamics and bifurcation
- Connexins and lens biology
- Neural Networks and Applications
- Immune Cell Function and Interaction
- Pressure Ulcer Prevention and Management
- Dendrimers and Hyperbranched Polymers
First Affiliated Hospital of Xi'an Jiaotong University
2024-2025
Chinese University of Hong Kong
2025
University of Hong Kong
2025
Hong Kong Polytechnic University
2024
Fudan University
2020-2023
Jimei University
2023
Southeast University
2022-2023
Yuxian People's Hospital
2023
Institute of Electrical and Electronics Engineers
2022
State Key Laboratory of Digital Medical Engineering
2022
Our study aimed to investigate the association between novel non-insulin-based metabolic score for insulin resistance (METS-IR) index and pre-hypertension (HTN) or HTN in normoglycemia Japanese participants.The NAGALA medical examination program at Murakami Memorial Hospital Gifu, Japan was found 1994. 15,453 participants enrolled this from 2004 2015 included retrospective explore METS-IR pre-HTN HTN. Covariates serum biomarkers clinicodemographic characteristics. Logistic regression applied...
Chemotherapy still accounts for a large proportion of the treatments tumors, but drug resistance and side effects caused by long-term chemotherapy should not be underestimated. In this work, combination strategy has been widely developed to overcome brought use single drugs improve therapeutic effect. However, in clinical applications, co-delivery is very difficult, different vivo kinetics due properties will lead decrease efficacy. Thus, design novel antitumor agents, including new platinum...
Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous and fatal disease. However, IPF treatment has been limited by the low drug delivery efficiency to lungs dysfunctional "injured" type II alveolar epithelial cell (AEC II). Here, we present surface-engineered nanoparticles (PER NPs) loading astaxanthin (AST) trametinib (TRA) adhered monocyte-derived multipotent (MOMC) forming programmed therapeutics (MOMC/PER). Specifically, surface designed backpack plenty of PER NPs that reach...
Aim We aimed to examine the relationship between Triglyceride–glucose (TyG) index and incidence of type 2 diabetes in people with different phenotypes obesity. Methods From May 1, 1994 December 31, 2016, 15,464 participants were enrolled medical examination program at Murakami Memorial Hospital determine TyG obesity after 5.38 years follow-up. Results Besides triglycerides, HbA1c%, FPG, was found be significantly associated (p <0.001), age BMI = 0.033), current smoker fatty liver...
Shortening the recipient warm ischemia time (rWIT) has been proven to be effective for improving short- and long-term outcomes after liver transplantation (LT) offsets negative impact of an extended cold time. However, few studies have conducted explore prognostic effects shortening rWIT in transplantations using a graft from extended-criteria donor (ECD). To investigate whether could improve ECD LT. Rat autologous orthotopic LT were performed with variable rWITs (0, 10, 20, 30 minutes)....
Abstract In the process of oil and gas production, reservoir pressure depletion leads to changes in pore in-situ stress caprock, which may reactivate closed faults break sealing make depleted reservoirs unsuitable for storage. order effectively evaluate caprock above provide a basis reasonable selection injection time location storage, this paper comprehensively considers fault slip potential (FSP) tensile (FTP), establishes evaluation model reservoir. The influences distance from top,...
Background Given the global prevalence of vitamin D deficiency, this study examines association between serum 25-hydroxyvitamin (25(OH)D) levels and lipid profiles, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density (HDL-C), triglycerides (TG). Methods In a cross-sectional analysis at Yuhuan People’s Hospital Physical Examination Center, 1535 asymptomatic individuals underwent anthropometric assessment blood sampling. Serum 25(OH)D were quantified by...
Background Insulin resistance (IR) is a normal feature of pregnancy and plays crucial role in the pathophysiology hypertensive disorder (HDP). The triglyceride-glucose index (TyG index) has been shown as simple reliable alternative IR marker. This work aimed to investigate association between TyG incidence HDP adverse outcomes. Methods From January 2016 December 2018, 289 women with 861 without were recruited at Shanghai Fifth People’s Hospital, Fudan University determine relationship...
Abstract To establish a system for the efficient one bacterial multi‐enzymatic biosynthesis of both ( R )‐ and S )‐β‐hydroxy nitriles, we co‐expressed alcohol dehydrogenases with opposite stereoselectivities, cofactor regeneration enzymes, halohydrin dehalogenase in Escherichia coli . By researching recycling various co‐expression strategies by selecting engineering dehalogenase, engineered two E. strains, which were subsequently used cascade reactions to produce chiral β‐hydroxy nitriles...
Oral squamous cell carcinoma (OSCC) is a usual oral cancer. Therefore, it's essential to identify targets for its early diagnosis and therapy. This research aimed explore the roles of human β-defensin-3 (hBD-3) nuclear factor-kappa B (NF-κB) p65 in pathogenesis progression OSCC. The connection between NF-κB carcinogenesis cancer was analyzed by immunohistochemical staining. relative expressions hBD-3 OSCC cells were evaluated qRT-PCR Western blot. Afterward, knocked down, overexpressed....
The aim of this study was to investigate the impact total soy saponins (TS) on free radical metabolism from quadriceps femoris muscle, serum testosterone, lactate dehydrogenase (LDH), and blood urea nitrogen (BUN) in rats exercised exhaustion.A one-time exhausted treadmill exercise session used. Sprague-Dawley were divided into 4 groups: a control group-animals receiving no TS (NTSNE), animals but group (TSNE), exhaustion (NTSE), (TSE). TSNE TSE groups fed at dosage 20 mg/kg body weight once...
Pulmonary arterial hypertension (PAH) refers to a rare, progressive disorder that is characterized by occlusive pulmonary vascular remodeling, resulting in increased pressure, right-sided heart failure, and eventual death. Emerging evidence from genetic investigations of pediatric-onset PAH highlights the strong basis underpinning PAH, deleterious variants multiple genes have been found cause PAH. Nevertheless, substantial heterogeneity, defects underlying overwhelming majority cases remain...
Asthma is a common obstructive airway disease characterized by inflammation and remodeling with progressive decline in lung function. Fangxiao Formula (FXF) an herbal medicine that has achieved significant clinical benefits toward asthma patients, but the relevant mechanism not yet been clarified. The aim of this study was to determine inhibitory effects FXF on remodeling, investigate activities TGF‑β/Smads signaling pathway rat model. Rats were sensitized ovalbumin (OVA) for six weeks...