A5100699987- SARS-CoV-2 and COVID-19 Research
- Cardiac and Coronary Surgery Techniques
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Neuroscience and Neuropharmacology Research
- Radiomics and Machine Learning in Medical Imaging
- Inflammasome and immune disorders
- Pancreatic function and diabetes
- Medical Imaging Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Liver physiology and pathology
- Advanced Drug Delivery Systems
- Transplantation: Methods and Outcomes
- Cancer-related molecular mechanisms research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- MRI in cancer diagnosis
- Vagus Nerve Stimulation Research
- T-cell and B-cell Immunology
- Cholinesterase and Neurodegenerative Diseases
- Biotin and Related Studies
- Cardiac Ischemia and Reperfusion
- Cancer Mechanisms and Therapy
- Ultrasound and Hyperthermia Applications
- Hippo pathway signaling and YAP/TAZ
Shandong University
2011-2023
Sichuan University
2019-2021
First Affiliated Hospital Zhejiang University
2020-2021
Tianjin University of Traditional Chinese Medicine
2020
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2020
Shandong Provincial QianFoShan Hospital
2019
Shandong First Medical University
2019
West China Hospital of Sichuan University
2019
State Key Laboratory of Biotherapy
2019
Shandong Provincial Hospital
2018
COVID-19 is caused by SARS-CoV-2. 1 As of July 16th, 2020, there were 13,579,581 diagnosed cases and 584,782 deaths attributed to reported globally (https://coronavirus.jhu.edu/map.html). 2 Unfortunately, still no effective drug or vaccine for treating this disease.To accelerate development, an urgent need identify critical molecular targets the role they play in infection.Herein, we that Orf9b localizes on membrane mitochondria suppresses type I interferon (IFN-I) responses through...
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spread worldwide. The mortality rate of patients with COVID-19 can be as high 4.2%.1 Despite optimized medical treatment, some end-stage pneumonia progressed to irreversible loss lung function, and those critical need admitted the intensive care unit (ICU).2–4 Lung transplantation is an effective treatment for pulmonary chronic diseases.5,6 At present, there no report in...
Tracking and eradicating Staphylococcus aureus in the periprosthetic microenvironment are critical for preventing joint infection (PJI), yet effective strategies remain elusive. Here, we report an implant nanoparticle coating that locoregionally yields bactericidal super chimeric antigen receptor macrophages (CAR-MΦs) to prevent PJI. We demonstrate plasmid-laden from can introduce S. aureus-targeted CAR genes caspase-11 short hairpin RNA (CASP11 shRNA) into macrophage nuclei generate CAR-MΦs...
Abstract Purpose Our study assessed the ability 18 F‐fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed (CT) radiomics to differentiate breast carcinoma from lymphoma using machine‐learning approach. Methods Sixty‐five nodules 44 patients diagnosed as or were included. Standardized uptake value (SUV) and radiomic features CT PET images extracted local image extraction software. Six discriminative models including PETa (based on clinical, SUV images), PETb (SUV PETc...
The present study aimed to investigate the potential role of long non‑coding RNA (lncRNA) Pvt1 oncogene (non‑protein coding) (PVT1) in progression and metastasis malignant melanoma, reveal its possible molecular mechanisms. expression lncRNA PVT1 melanoma tissues adjacent normal skin from patients with A‑375 sk‑mel‑5 cell lines, was analyzed using reverse transcription‑quantitative polymerase chain reaction western blot analyses. effects on proliferation, cycle, migration invasion were MTT...
Aim: Hybrids composed of various materials are highly versatile for drug delivery in tumor therapy including hepatocellular carcinoma. Herein, a sorafenib (SF)-loaded biomacromolecule hyaluronic acid (HA)/lipid hybrid nanoparticles (HA/SF-cLNS) were developed targeting delivery. Materials & methods: In vitro assays determined HA/SF-cLNS release behavior, enzymatic degradation, uptake and cytotoxicity. H22-bearing liver cancer xenograft murine models used to evaluate the biodistribution...
The interest using novel drug delivery systems to improve oral bioavailability of with poor solubility is increasing. In this study, a new system, polybutylcyanoacrylate nanoparticles (PBCNs), was introduced the puerarin (PUE). PUE-loaded PBCN successfully prepared by anionic polymerization method. Characterization evaluated morphology, size, zeta potential, and in vitro release study. loading PUE exhibited spherical shape under transmission electron microscopy an average size 159.4 nm,...
Rotation of the left ventricular (LV) apex to base, or LV torsion, is related myocardial contractility and structure has recently been recognized as a sensitive indicator cardiac performance, but it difficult measure. The recent development 2-dimensional (2D) speckle tracking imaging (STI) may provide powerful means assessing torsion. This study was conducted evaluate global regional twist in patients with anterior wall infarction (AMI) disease before after revascularization by STI.2D STI...
Abstract The coronavirus disease 2019 (COVID-19) caused by Severe acute respiratory syndrome 2 (SARS-CoV-2) has quickly spread worldwide and infected more than ten million individuals. One of the typical features COVID-19 is that both type I III interferon (IFN)-mediated antiviral immunity are suppressed. However, molecular mechanism which SARS-CoV-2 evades this remains elusive. Here, we report membrane (M) protein inhibits production IFNs induced cytosolic dsRNA-sensing pathway...
Two-stage pH-sensitive DOX·HCl loaded core–shell nanoparticles (CPOD) with dual drug-loading strategies showed pretty <italic>in vivo</italic> anti-tumor efficacy.
Cardiomyocyte (CM) transplantation is a promising option for regenerating infarcted myocardium. However, poor cell survival and residence rates reduce the efficacy of transplantation. Gelatin (GA) hydrogel as frequently-used carrier possible approach to increase rate CMs. In this study, microbial transglutaminase (mTG) chemical crosslinkers glutaraldehyde, genipin, 1-ethyl-3-(3-dimethyl aminopropyl)-carbodiimide were employed prepare GA hydrogels. The mechanical properties degradation...