A5072916060- Prostate Cancer Treatment and Research
- Cancer Treatment and Pharmacology
- Hormonal and reproductive studies
- Prostate Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Urologic and reproductive health conditions
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- HER2/EGFR in Cancer Research
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Bariatric Surgery and Outcomes
- Cancer Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Proteoglycans and glycosaminoglycans research
- Fibroblast Growth Factor Research
- thermodynamics and calorimetric analyses
- Hepatitis C virus research
- Synthesis of β-Lactam Compounds
- Gallbladder and Bile Duct Disorders
- Microtubule and mitosis dynamics
- Estrogen and related hormone effects
National Cancer Institute
2024-2025
National Institutes of Health
2024
Center for Cancer Research
2024
Chiba University
1983-2019
Osaka Minami Medical Center
2017
Osaka Medical and Pharmaceutical University
2017
Tokyo Medical Center
2016
National Hospital Organization
2000-2016
Teikyo University
2000-2002
BC Cancer Agency
1995-1997
Cabozantinib and nivolumab (CaboNivo) alone or with ipilimumab (CaboNivoIpi) have shown promising efficacy safety in patients metastatic urothelial carcinoma (mUC), renal cell (mRCC), rare genitourinary (GU) tumors a dose-escalation phase I study. We report the final data analysis of safety, overall response rate (ORR), progression-free survival (PFS), (OS) seven expansion cohorts.
Topoisomerase III-beta (Top3b) reduces nucleic acid torsional stress and intertwining generated during RNA DNA metabolism while protecting the genome from pathological R-loops, which otherwise result in breakage instability. By studying Top3b knockout mice (Top3b-KO), we find that loss of accelerates development spontaneous lymphoid tumors arising spleens lymph nodes, organs with prominent expression. Aging Top3b-KO also display splenomegaly systemic immune alterations including neutrophilia...
Abstract Immune checkpoint blockade (ICB) combined with chemotherapy as a first-line treatment for extensive-stage small-cell lung cancer (ES-SCLC) has shown modest survival benefits. While subset of patients immune-inflamed tumors respond to ICB, the mechanisms underlying these responses and lack predictive biomarkers in clinical practice remain challenges. In this work, we identify high NOTCH1 expression key predictor overall (OS) treated atezolizumab (atezo) plus both ASCL1-enriched (HR...
The frequency of integration with human papillomavirus (HPV) and its genotypes in Japanese penile cancer was examined relation to p53 gene mutations using polymerase chain reaction amplification. Tissues were obtained from 13 patients (eight freshly frozen five paraffin-embedded samples). HPV DNA detected seven out the (54%), their type 16 four, 31 one 33 two cases. Neither HPV-detected nor -undetected tissues showed mutated alterations exons 4-9 genes. results suggest be, at least some...
ABSTRACT [ 3 H]Methyltrienolone-bound and unbound androgen receptors from mouse submandibular glands bound to DNA-cellulose a similar extent after gel chromatography. The sedimented at 6 S in low-salt gradient whereas if were transformed with KCl (0·4 mol/l) they 4 S. On DEAE-anion exchange chromatography both eluted concentration of 0·07 mol KCl/l. These results suggest that two states exist. A receptor may well derive by partial dissociation an 8 non-transformed this is caused Molybdate...
Background LMB-100 is a mesothelin (MSLN)-targeting recombinant immunotoxin (iTox) carrying Pseudomonas exotoxin A payload that has shown promise against solid tumors, however, efficacy limited by the development of neutralizing anti-drug antibodies (ADAs). Tofacitinib an oral Janus Kinase (JAK) inhibitor prevented ADA formation iTox in preclinical studies. Methods phase 1 trial testing and tofacitinib patients with MSLN-expressing cancers (pancreatic adenocarcinoma, n=13;...
When the chromatin prepared from male rat livers interacted with [3H] testosterone-receptor complex livers, binding was much higher than when free testosterone, indicating that formation of is prerequisite for interaction chromatin. and bound proteins were extracted into three fractions based on their extractability or solubility in salt solutions, radioactivities found 0.35 M NaCl-extract 2.0 NaCl residual fraction. Chromatin fractionated NaCl-soluble, NaCl-soluble insoluble fractions,...
TPS105 Background: Japan Breast Cancer Research Group (JBCRG) is collaborating with International (BIG) to develop new evidence for breast cancer treatments in Japan. Combination regimens of anthracyclines and taxanes have been widely used as preoperative systemic therapy (PST) patients operable cancer. However, we several clinical questions related PST: (1) additional effect cyclophosphamide (CPA) standard regimen (anthracycline taxane) identify preferred PST, (2) preferable order...
Abstract Background: Neoadjuvant chemotherapy plus trastuzumab results in a 30% to 50% pathologic complete response (pCR) rate HER-2 positive breast cancer and has been associated with improved therapeutic outcomes. Thus, the pCR can be useful evaluating novel agents this patient population. Albumin-bound (nab)-paclitaxel reduce toxicity of Paclitaxel while maintaining its efficacy. We reported that neoadjuvant therapy using Anthracycline based regimens (EC,AC,FEC) followed by combination...