Keval Sidhpura
A5081895226- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Parkinson's Disease Mechanisms and Treatments
- Dermatology and Skin Diseases
- Hair Growth and Disorders
- IL-33, ST2, and ILC Pathways
- Alzheimer's disease research and treatments
- Immunotherapy and Immune Responses
- Mitochondrial Function and Pathology
- Parkinson's Disease and Spinal Disorders
- Pharmaceutical studies and practices
Newcastle University
2020-2024
Palatine tonsils are secondary lymphoid organs (SLOs) representing the first line of immunological defense against inhaled or ingested pathogens. We generated an atlas human tonsil composed >556,000 cells profiled across five different data modalities, including single-cell transcriptome, epigenome, proteome, and immune repertoire sequencing, as well spatial transcriptomics. This census identified 121 cell types states, defined developmental trajectories, enabled understanding functional...
Human prenatal skin is populated by innate immune cells, including macrophages, but whether they act solely in immunity or have additional functions morphogenesis unclear. Here we assembled a comprehensive multi-omics reference atlas of human (7-17 post-conception weeks), combining single-cell and spatial transcriptomics data, to characterize the microanatomical tissue niches skin. This revealed that crosstalk between non-immune cells underpins formation hair follicles, implicated scarless...
Summary Human prenatal skin is populated by innate immune cells including macrophages, and whether they act solely in immunity or have additional functions morphogenesis unclear. We assembled the first comprehensive multi-omic reference atlas of human (7-16 post-conception weeks), combining single cell spatial transcriptomic data, to characterise skin’s microenvironmental cellular organisation. This revealed that crosstalk between non-immune underpins formation hair follicles, has...
Abstract Background Lewy body diseases (LBD) are characterised by pathology, cell loss and mitochondrial dysfunction, but the overlap between these three features is not well understood. We have explored hypothesis that neurodegeneration in LBD result of energy failure cells with high demands, such as cortical fast‐spiking interneurons cholinergic basal forebrain neurons, irrespective accumulation. Method obtained post‐mortem substantia innominata, prefrontal cortex inferior temporal brain...
Background: Stroke doubles the risk of dementia in over 65s and around a quarter stroke survivors develop progressive cognitive decline more than 3 months after stroke, eventually leading to vascular dementia.Impaired executive function is characteristic feature dementia, including post (PSD).PSD associated with pathology anterior circuits, but mechanisms PSD are unclear.This study aims find novel pathways by which cell damage brain can give rise PSD. Methods: Dorsal lateral prefrontal...