A5092361995- Digestive system and related health
- Pancreatitis Pathology and Treatment
- Neonatal Respiratory Health Research
- Amoebic Infections and Treatments
- Immune cells in cancer
- MicroRNA in disease regulation
- Adenosine and Purinergic Signaling
- Heme Oxygenase-1 and Carbon Monoxide
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Malaria Research and Control
Bernhard Nocht Institute for Tropical Medicine
2023-2024
Universität Hamburg
2023-2024
University Medical Center Hamburg-Eppendorf
2023-2024
Macrophages are functionally heterogeneous cells essential for apoptotic cell clearance. Apoptotic defined by homogeneous characteristics, ignoring their original lineage identity. We found that in an interleukin-4 (IL-4)-enriched environment, the sensing of neutrophils macrophages triggered tissue remodeling signature. Engulfment hepatocytes promoted a tolerogenic phenotype, whereas phagocytosis T had little effect on IL-4-induced gene expression. In mouse model parasite-induced pathology,...
Plasmodium falciparum, a human malaria parasite, develops in red blood cells (RBCs), which represent approximately 70% of all cells. Additionally, RBC-derived extracellular vesicles (RBC-EVs) 7.3% the total EV population. The roles microRNAs (miRNAs) consequences P. falciparum infection are unclear. Here, we analyzed miRNA profiles non-infected RBCs (niRBCs), ring-infected (riRBCs), and trophozoite-infected (trRBCs), as well those EVs secreted from these Hsa-miR-451a was most abundant RBC...
Abstract The parasitic protozoan Entamoeba histolytica secretes extracellular vesicles (EVs), but so far little is known about their function in the interaction with host immune system. Infection E. trophozoites can lead to formation of amebic liver abscesses (ALAs), which pro-inflammatory responses Ly6C hi monocytes contribute damage. Men exhibit a more severe pathology as result higher monocyte recruitment and stronger response. To investigate role EVs pathogenicity response, we studied...
The initiation of tissue remodeling following damage is a critical step in preventing the development immune-mediated diseases. Several factors contribute to mucosal healing, leading innovative therapeutic approaches for managing intestinal disorders. However, uncovering alternative targets and gaining mechanistic insights are imperative enhance therapy efficacy broaden its applicability across different Here we demonstrate that Nmes1, encoding Normal Mucosa Esophagus-Specific gene 1, also...