Amirah Al Jawazneh
A5045131444- Immune cells in cancer
- Immune Cell Function and Interaction
- Digestive system and related health
- Phagocytosis and Immune Regulation
- Immune responses and vaccinations
- PARP inhibition in cancer therapy
- Neonatal Respiratory Health Research
- COVID-19 Clinical Research Studies
- Single-cell and spatial transcriptomics
- Adenosine and Purinergic Signaling
Bernhard Nocht Institute for Tropical Medicine
2021-2024
University Medical Center Hamburg-Eppendorf
2021-2024
Universität Hamburg
2021-2024
Macrophages are functionally heterogeneous cells essential for apoptotic cell clearance. Apoptotic defined by homogeneous characteristics, ignoring their original lineage identity. We found that in an interleukin-4 (IL-4)-enriched environment, the sensing of neutrophils macrophages triggered tissue remodeling signature. Engulfment hepatocytes promoted a tolerogenic phenotype, whereas phagocytosis T had little effect on IL-4-induced gene expression. In mouse model parasite-induced pathology,...
The lung is constantly exposed to the outside world and optimal adaptation of immune responses crucial for efficient pathogen clearance. However, mechanisms that lead lung-associated macrophages' functional developmental remain elusive. To reveal such mechanisms, we developed a reductionist model environmental intranasal β-glucan exposure, allowing detailed interrogation molecular pulmonary macrophage adaptation. Employing single-cell transcriptomics, high-dimensional imaging flow cytometric...
Male sex represents one of the major risk factors for severe COVID-19 outcome. However, underlying mechanisms that mediate sex-dependent disease outcome are as yet unknown. Here, we identify CYP19A1 gene encoding testosterone-to-estradiol metabolizing enzyme (also known aromatase) a host factor contributes to worsened in SARS-CoV-2-infected males. We analyzed exome sequencing data obtained from human cohort (n = 2,866) using machine-learning approach and CYP19A1-activity-increasing mutation...
The initiation of tissue remodeling following damage is a critical step in preventing the development immune-mediated diseases. Several factors contribute to mucosal healing, leading innovative therapeutic approaches for managing intestinal disorders. However, uncovering alternative targets and gaining mechanistic insights are imperative enhance therapy efficacy broaden its applicability across different Here we demonstrate that Nmes1, encoding Normal Mucosa Esophagus-Specific gene 1, also...
Summary The lung is constantly exposed to the outside world and optimal adaptation of immune responses crucial for efficient pathogen clearance. However, mechanisms which lead functional developmental lung-associated macrophages remain elusive. To reveal such mechanisms, we developed a reductionist model environmental intranasal β-glucan exposure, allowing detailed interrogation molecular pulmonal macrophage adaptation. Employing single-cell transcriptomics, high dimensional imaging flow...