A5063899959- Gut microbiota and health
- Probiotics and Fermented Foods
- Genomics and Phylogenetic Studies
- Clostridium difficile and Clostridium perfringens research
- Microbial Metabolites in Food Biotechnology
- Bacteriophages and microbial interactions
- Bariatric Surgery and Outcomes
- Polyamine Metabolism and Applications
- RNA and protein synthesis mechanisms
- Paleopathology and ancient diseases
- Diet and metabolism studies
- Microbial infections and disease research
- Gastrointestinal motility and disorders
- Aquaculture disease management and microbiota
- Infant Nutrition and Health
- Bacterial Identification and Susceptibility Testing
- Identification and Quantification in Food
- Plant Pathogens and Fungal Diseases
- Food composition and properties
- Food Security and Health in Diverse Populations
- Nutrition and Health in Aging
- Antimicrobial Resistance in Staphylococcus
- Legume Nitrogen Fixing Symbiosis
- Archaeology and ancient environmental studies
- Salmonella and Campylobacter epidemiology
University of Milan
2011-2025
British Red Cross
2019
University of Parma
2014-2018
The correct establishment of the human gut microbiota represents a crucial development that commences at birth. Different hypotheses propose infant is derived from, among other sources, mother's fecal/vaginal and milk. composition bifidobacterial communities 25 mother-infant pairs was investigated based on an internal transcribed spacer (ITS) approach, combined with cultivation-mediated genomic analyses. We identified strains/communities are shared between mothers their corresponding...
Abstract Bifidobacteria are common and frequently dominant members of the gut microbiota many animals, including mammals insects. Carbohydrates considered key carbon sources for microbiota, imposing strong selective pressure on complex microbial consortium gut. Despite its importance, genetic traits that facilitate carbohydrate utilization by still poorly characterized. Here, genome analyses 47 representative Bifidobacterium (sub)species revealed genes predicted to be required degradation...
ABSTRACT Passage through the birth canal and consequent exposure to mother's microbiota is considered represent initiating event for microbial colonization of gastrointestinal tract newborn. However, a precise evaluation such suspected vertical transmission has yet be performed. Here, we evaluated microbiomes four sample sets, each consisting fecal milk samples corresponding infant's sample, by means amplicon-based profiling supported shotgun metagenomics data two key samples. Notably,...
Abstract The gut microbiota composition of elderly hospitalized patients with Clostridium difficile infection (CDI) exposed to previous antibiotic treatment is still poorly investigated. aim this study was compare the by means 16S rRNA microbial profiling among three groups (age ≥ 65) under standard diet including 25 CDI-positive (CDI group), 29 CDI-negative (AB+ group) and 30 subjects not on (AB− group). functional properties microbiomes vs were also assessed shotgun metagenomics. A...
Abstract Reduced biodiversity and increased representation of opportunistic pathogens are typical features gut microbiota composition in aging. Few studies have investigated their correlation with polypharmacy, multimorbidity frailty. To assess it, we analyzed the fecal from 76 inpatients, aged 83 ± 8. Microbiome (Chao1 index) relative abundance individual bacterial taxa were determined by next-generation 16S rRNA microbial profiling. Their number drugs, indexes frailty verified using...
The gastrointestinal tract of poultry is densely populated with microorganisms, which are presumed to interact the host and ingested feed. Comparison gut microbiota chickens used for large-scale commercial production (Broiler Chicken, BC) those grown in semi-wild conditions (Free-Range FRC) revealed that at phylum level Firmicutes was dominant community BC, while FRC contained higher levels Bacteroidetes Proteobacteria. Such differences may be due diet and/or intensive use antibiotics BC....
Objectives The involvement of the gut microbiota in pathogenesis calcium nephrolithiasis has been hypothesised since discovery oxalate-degrading activity Oxalobacter formigenes , but never comprehensively studied with metagenomics. aim this case–control study was to compare faecal composition and functionality between recurrent idiopathic stone formers (SFs) controls. Design Faecal samples were collected from 52 SFs 48 controls (mean age 48±11). analysed through 16S rRNA microbial profiling...
Ulcerative colitis (UC) is associated with a substantial alteration of specific gut commensals, some which may be involved in microbiota-mediated protection. In this study, microbiota cataloging UC patients by 16S rRNA microbial profiling revealed marked reduction bifidobacteria, particular the Bifidobacterium bifidum species, thus suggesting that taxon plays biological role aetiology UC. We investigated further through an vivo trial testing effects oral treatment B. PRL2010 wild-type murine...
The Bifidobacterium genus currently encompasses 48 recognized taxa, which have been isolated from different ecosystems. However, the current phylogeny of bifidobacteria is hampered by relative paucity genotypic data. Here, we reassessed taxonomy this bacterial using genome-based approaches, demonstrated that previous taxonomic view contained several inconsistencies. In particular, high levels genetic relatedness were shown to exist between particular taxa would not justify their status as...
Abstract Bifidobacteria are members of the human gut microbiota, being numerically dominant in colon infants, while also prevalent large intestine adults. In this study, we determined and analyzed pan-genome Bifidobacterium adolescentis , which is one many bacteria found adult microbiota. silico analysis genome sequences eighteen B. strains isolated from various environments, such as milk, feces bovine rumen, revealed a high level genetic variability, resulting an open pan-genome. Compared...
The microbiota of the human gastrointestinal tract (GIT) may regularly be exposed to antibiotics, which are used prevent and treat infectious diseases caused by bacteria fungi. Bacterial communities gut retain a reservoir antibiotic resistance (AR) genes, therapy thus positively selects for those microorganisms that harbor such genetic features, causing modulation. During first months following birth, bifidobacteria represent some most dominant components microbiota, although little is known...
Members of the Bifidobacteriaceae family represent both dominant microbial groups that colonize gut various animals, especially during suckling stage their life, while they also occur as pathogenic bacteria urogenital tract. The pan-genome genus Bifidobacterium has been explored in detail recent years, though genomics not yet received much attention. Here, a comparative genomic analyses 67 (sub) species including all currently recognized genera this family, i.e., Aeriscardovia,...
The composition of the gut microbiota mammals is greatly influenced by diet. Therefore, evaluation different food ingredients that may promote changes in an attractive approach to treat disturbances. In this study, three dietary fibers, such as inulin (I, 10%), resistant starch (RS, and citrus pectin (3%), were employed supplements normal chow diet adult male rats for 2 weeks. Fecal corresponding metabolite profiles assessed before after prebiotics supplementation. A general increase...
Bifidobacteria are bacterial gut commensals of mammals, birds and social insects that perceived to influence the metabolism/physiology their host. In this context, members Bifidobacterium bifidum species believed significantly contribute overall microbiota human at infant stage. However, molecular reasons for adaptation environment poorly understood. study, we analysed pan-genome B. by decoding genomes 15 strains, which highlighted existence a conserved gene uniquely present in...
Abstract The microbiota of the gastrointestinal tract plays an important role in human health. In addition to their metabolic interactions with dietary constituents, gut bacteria may also be involved more complex host interactions, such as modulation immune system. Furthermore, composition reducing risk contracting particular infections. Changes during individual's lifespan are accompanied by modifications multiple health parameters, and observations have prompted intense scientific efforts...
Phage predation is one of the key forces that shape genetic diversity in bacterial genomes. Phages are also believed to act as modulators microbiota composition and, consequently, agents drive speciation complex communities. Very little known about occurrence and variability (pro)phages within Bifidobacterium genus, a dominant group human infant microbiota. Here, we performed cataloguing predicted prophage sequences from genomes all currently recognized bifidobacterial type strains. We...
ABSTRACT Modulation of the intestinal microbial ecosystem (IME) is a useful target to establish probiotic efficacy in healthy population. We conducted randomized, double-blind, crossover, and placebo-controlled intervention study determine impact Bifidobacterium bifidum strain Bb on IME adult volunteers both sexes. High-throughput 16S rRNA gene sequencing was used characterize fecal microbiota before after 4 weeks daily cell consumption. The intake approximately one billion live B. cells...