A5033147769- Autoimmune and Inflammatory Disorders Research
- Viral Infections and Vectors
- Autoimmune and Inflammatory Disorders
- Antibiotic Use and Resistance
- Pharmaceutical Practices and Patient Outcomes
- Oral Health Pathology and Treatment
- Healthcare Systems and Practices
- Pneumonia and Respiratory Infections
- Poisoning and overdose treatments
- Antibiotics Pharmacokinetics and Efficacy
- Mosquito-borne diseases and control
- Neurogenetic and Muscular Disorders Research
- Vasculitis and related conditions
- Bacterial Identification and Susceptibility Testing
- Peripheral Neuropathies and Disorders
- Eosinophilic Disorders and Syndromes
- Otitis Media and Relapsing Polychondritis
- Streptococcal Infections and Treatments
- Chronic Kidney Disease and Diabetes
- Immune Cell Function and Interaction
- Liver Disease and Transplantation
- Mast cells and histamine
- Fungal Infections and Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Kidney Injury Research
Hôpital Manchester
2014-2024
Institut Pasteur
2018
Hôpital Universitaire Dupuytren
2018
Université de Reims Champagne-Ardenne
2018
CD4+ T cells are vital for host defense and immune regulation. However, the fundamental role of CD4 itself remains enigmatic. We report seven patients aged 5–61 years from five families four ancestries with autosomal recessive deficiency a range infections, including recalcitrant warts Whipple’s disease. All homozygous rare deleterious variants impacting expression canonical isoform. A shorter expressed isoform that interacts LCK, but not HLA class II, is affected by only one variant. lack...
In France, pneumococcal vaccination in adults is recommended for risk groups (chronic conditions/immunosuppression). We conducted a study on invasive disease (IPD) to identify factors associated with severity and death. included IPD cases, excluding meningitis, from 25 acute care hospitals 6 regions. defined severe cases as those shock or sepsis intensive unit admission/mechanical ventilation. deaths occurring within 30 days of hospitalization. Infectious specialists collected...
Abstract We conducted a multicenter, retrospective cohort study of hospitalized patients with serologically proven nephropathia epidemica (NE) living in Ardennes Department, France, during 2000–2014 to develop bioclinical test predictive severe disease. Among 205 patients, 45 (22.0%) had NE. found the following factors NE: nephrotoxic drug exposure (p = 0.005, point value 10); visual disorders 0.02, 8); microscopic or macroscopic hematuria 0.04, 7); leukocyte count >10 × 109 cells/L 0.01,...
There are emerging eosinophil-related considerations concerning viral infections. The role of eosinophils has poorly been evaluated during Hantavirus infection.The aim this study was to determine the prevalence eosinophilia (defined as an eosinophil count above 500 cells/mm3) haemorrhagic fever with renal syndrome (HFRS) in a large cohort patients, and identify factors associated eosinophilia.Among 387 patients hospitalized for HFRS, 98 (25.3%) had eosinophilia. By univariate analysis,...
<h3>Objectives</h3> To validate Fautrel criteria set for classification of adult onset Still9s disease (AOSD), and to establish its discriminative performance that the Yamaguchi9s set. <h3>Methods</h3> We retrospectively reviewed medical charts 344 patients who had ferritin glycosylated measured at biochemistry laboratory Bichat Hospital. Medical informations were extracted via a standardized form. All clinical, biological, imaging features collected, as well elements in favor an alternative...