A5029666317- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Plant biochemistry and biosynthesis
- Lipoproteins and Cardiovascular Health
- RNA modifications and cancer
- Coenzyme Q10 studies and effects
- Diabetes Treatment and Management
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- ATP Synthase and ATPases Research
- Diet and metabolism studies
- Birth, Development, and Health
- Diabetes Management and Research
- Muscle metabolism and nutrition
- Platelet Disorders and Treatments
- Computational Drug Discovery Methods
- Renal and related cancers
- Cell Adhesion Molecules Research
University of Utah
2022-2024
China Pharmaceutical University
2016-2017
State Key Laboratory of Natural Medicine
2016-2017
Carbohydrates and lipids provide the majority of substrates to fuel mitochondrial oxidative phosphorylation. Metabolic inflexibility, defined as an impaired ability switch between these fuels, is implicated in a number metabolic diseases. Here, we explore mechanism by which physical inactivity promotes inflexibility skeletal muscle. We developed mouse model sedentariness, small cage (SMC), that, unlike other classic models disuse mice, faithfully recapitulated responses that occur humans....
The free fatty acid receptor 1 (FFA1) plays a key role in amplifying glucose-stimulated insulin secretion pancreatic β-cells.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disorder marked by lipid accumulation, leading to steatohepatitis (MASH). A key feature of the transition MASH involves oxidative stress resulting from defects in mitochondrial phosphorylation (OXPHOS). Here, we show that pathological alterations composition inner membrane (IMM) directly instigate electron transfer inefficiency promote stress. Specifically, cardiolipin (CL) was downregulated with MASLD/MASH...
Intro: Alport Syndrome (AS) is a rare hereditary disorder characterized by progressive renal impairment and sensorineural hearing loss, resulting from mutations in the genes that encode COL4 synthesis. X-linked (XLAS) most common form of AS, comprising an estimated 80% all human AS cases (the others being various forms autosomal recessive or dominant AS), caused on COL4A5 gene. However, to date, there are no animal models XLAS. Methods: To facilitate comprehensive preclinical investigations...
Abstract Carbohydrates and lipids provide the majority of substrates to fuel mitochondrial oxidative phosphorylation (OXPHOS). Metabolic inflexibility, defined as an impaired ability switch between these fuels, is implicated in a number metabolic diseases. Here we explore mechanism by which physical inactivity promotes inflexibility skeletal muscle. We developed mouse model sedentariness small cage (SMC) that, unlike other classic models disuse mice, faithfully recapitulates responses that...