A5064302704- Liver Disease Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Pneumonia and Respiratory Infections
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Respiratory Support and Mechanisms
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Liver Disease and Transplantation
- Liver physiology and pathology
- Clinical Nutrition and Gastroenterology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
TU Dresden
2018-2025
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2023-2025
University Hospital Carl Gustav Carus
2019-2025
German Center for Lung Research
2024
Berlin-Brandenburger Centrum für Regenerative Therapien
2019
A deeper epigenomic understanding of spatial organization cells in human tissues is an important challenge. Here we report the first combined positional analysis transcriptomes and methylomes across three micro-dissected zones (pericentral, intermediate periportal) liver. We identify pronounced anti-correlated transcriptional methylation gradients including a core 271 genes controlling zonated metabolic morphogen networks observe prominent porto-central gradient DNA at binding sites 46...
Abstract Immunosuppression constitutes a significant risk for community-acquired pneumonia (CAP). Nevertheless, specific causes of immunosuppression and their relevance incidence, etiology prognosis CAP are insufficiently investigated. We conducted population-based cohort study within statutory health insurance in Germany from 2015 to 2018. was retrieved by ICD-10-GM codes. Episodes were identified coded conditions (hematologic neoplasms, stem cell or organ transplantation, neutropenia, HIV,...
Immunsuppression (IS) ist ein wichtiger Risikofaktor für ambulant erworbene Pneumonien (CAP). Jedoch die Relevanz verschiedener Ursachen der IS Inzidenz, Ätiologie und Prognose CAP wenig untersucht.
Einleitung Immunsuppression (IS) ist ein wichtiger Risikofaktor für ambulant erworbene Pneumonien (CAP). Jedoch die Relevanz verschiedener Ursachen der IS Inzidenz, Ätiologie und Prognose CAP wenig untersucht.
Zonation of liver metabolism and its regulation has been intensely studied in the past but was focused on healthy organ animal models. Major break throughs were accomplished especially using so called omics-techniques. Although cirrhosis become one major problems western world, it not yet achieved to use those methods at this stage disease progression.
A deeper epigenomic understanding of spatial organization cells in human tissues is an important challenge. Here we report the first combined positional analysis transcriptomes and methylomes across three micro-dissected zones (pericentral, intermediate periportal) liver. We identify pronounced anti-correlated transcriptional methylation gradients including a core 271 genes controlling zonated metabolic morphogen networks observe prominent porto-central gradient DNA at binding sites 46...
Die metabolische Zonierung der Leber und deren Regulation wurde in den letzten Jahrzehnten intensiv erforscht. Das Hauptaugenmerk meist an Tiermodellen durchgeführten Versuche lag dabei vor allem auf dem gesunden Organ. Insbesondere die sogenannten omics-Methoden führten hierbei zu bahnbrechenden Ergebnissen. Trotzdem Leberzirrhose eine wichtigsten Erkrankungen westlicher Länder darstellt, ist es bisher nicht gelungen diesem fortgeschrittenen Stadium unter Nutzung dieser Techniken analysieren.