A5033813684- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Genetic Associations and Epidemiology
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Sodium Intake and Health
- Genetics and Neurodevelopmental Disorders
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Congenital heart defects research
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Neurological Disease Mechanisms and Treatments
- Renal and Vascular Pathologies
- Digestive system and related health
- RNA and protein synthesis mechanisms
- Chemical Reaction Mechanisms
- Chronic Kidney Disease and Diabetes
- Peroxisome Proliferator-Activated Receptors
- Chromosomal and Genetic Variations
- Heart Failure Treatment and Management
- Renin-Angiotensin System Studies
- Management of metastatic bone disease
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Birth, Development, and Health
Dana-Farber Cancer Institute
2024
United States Department of the Army
2024
Mayo Clinic
1985-2015
WinnMed
2015
Emory University
2012
University of Mississippi
2005
Hypertension Institute
2005
Westmead Hospital
2004
Age and race categories or renin profiling have been recommended to predict blood pressure responses monotherapy with a beta-blocker thiazide diuretic. Whether these other characteristics when the drugs are administered as add-on therapy is uncertain.We evaluated predictors of response in 363 men women < =65 years age primary hypertension (152 blacks, 211 whites), 86 whom (24%) were untreated 277 (76%) withdrawn from previous antihypertensive before randomization either atenolol followed by...
Response to antihypertensive drugs varies widely among individuals. We studied characteristics that might be predictive of blood pressure (BP) response in 203 African-American and 236 non-Hispanic white subjects with essential hypertension treated candesartan, 32 mg/day for 6 weeks, after a drug-free washout period at least 4 weeks (baseline). Measurements enrollment, baseline, the end treatment were incorporated into linear regression models quantify their additive contributions predicting...
Studies finding an increased maximal rate of Na-Li countertransport in red blood cells from persons with essential hypertension and their normotensive offspring have raised the possibility that may serve as a marker for genetic predisposition to hypertension. We studied 238 randomly selected donors representative population Rochester, Minnesota. The mean value (+/- SD) units mmoles lithium efflux per liter hour was 0.29 +/- 0.12. distribution values among continuous. An analysis...
Strategies for initial drug therapy of hypertension are a thiazide diuretic all or selection based on age/race criteria plasma renin activity (PRA). It is uncertain which these strategies will achieve the highest control rate among patients with stage 1 essential hypertension. We sought to compare rates 3 strategies: (i) all, (ii) black subjects and white aged ≥50 years renin-angiotensin system blocker <50 years, (iii) PRA < 0.6ng/ml/h (suppressed PRA) ≥ (nonsuppressed PRA). Blood pressure...
LINE-1 (L1) retrotransposition is widespread in many cancers, especially those with a high burden of chromosomal rearrangements. However, whether and to what degree L1 activity directly impacts genome integrity unclear. Here, we apply whole-genome sequencing experimental models expression comprehensively define the spectrum genomic changes caused by L1. We provide definitive evidence that frequently causes both local long-range rearrangements, small large segmental copy-number alterations,...
For combination antihypertensive therapy with thiazide diuretics and β-blockers, the effect of order initiation drugs on outcome has not been tested. Patients uncomplicated hypertension were randomized to receive either hydrochlorothiazide (HCTZ) or atenolol monotherapy, followed by addition alternative drug. Blood pressure (BP) responses evaluated race drug initiation. A total 368 participants received therapy. Among participants, blacks showed a greater BP-lowering than whites did HCTZ...
Background:The objective of this study was to investigate relationships between blood pressure (BP) determined by ambulatory monitoring and coronary artery calcification (CAC) electron beam computed tomography (EBCT) in middle-aged younger adults without symptoms disease.
Abnormalities of HDL cholesterol (HDL-C), triglycerides, and LDL particle size are present in familial dyslipidemic hypertension. We investigated heritability these three lipid traits the extent to which shared effects genes (pleiotropy) contribute additive genetic variation each trait hypertensive sibships. Subjects included 788 individuals (60% women) ascertained through sibships with ≥2 members diagnosed hypertension before age 60 years. The was measured by polyacrylamide gel...
Background:The Modification of Diet in Renal Disease (MDRD) equation is often used to determine an estimated glomerular filtration rate (eGFR) from serum creatinine. This study compared kidney disease as defined by reduced eGFR, elevated creatinine, or urinary albumin-to-creatinine ratio (ACR).
Alterations in microvascular and conduit artery function contribute to target organ damage hypertension. We investigated the association of cardiovascular (CV) risk factors with hypertensive subjects.Participants included 504 hypertensives (aged 62.1 +/- 9.8 years, 42% men) from community, without history symptomatic CV disease. Brachial ultrasound was performed measure forearm blood flow (FBF) at rest during reactive hyperemia (markers function) flow-mediated dilatation (FMD) brachial (a...
BackgroundMidregional pro-atrial natriuretic peptide (MR-proANP) is a newly described stable fragment of the N-terminal part peptide. We tested hypothesis that in adults with essential hypertension, plasma levels MR-proANP would be associated systolic blood pressure (SBP), pulse pressure, and hypertension severity.
High-density lipoprotein (HDL)-cholesterol, triglycerides, and LDL particle size are correlated lipid traits. Abnormal levels of these traits frequent in hypertensive individuals contribute to increased risk coronary heart disease (CHD). We performed univariate bivariate linkage analyses identify genomic regions that influence exert pleiotropic effects on the sibships. Subjects included 691 non-Hispanic white (mean age 63.1±8.5 years, 57% women, 78% hypertensive) ascertained through sibships...
African Americans with hypertension are prone to target-organ damage and adverse cardiovascular events. Biomarkers for early detection of in this ethnic group needed. Adrenomedullin (ADM) is a circulating vasoactive peptide vasodilatory antiproliferative effects that has been reported be elevated adults hypertension.We investigated the associations plasma levels mid-regional pro-ADM (MR-proADM) pulse pressure, left ventricular mass (LVM), albuminuria 1,034 African-American (65 +/- 9 years,...
Background:Dyslipidemia in hypertensive sibships may be characterized by atherogenic small low-density lipoprotein (LDL) particles. Whether LDL particle size is associated with the extent of coronary atherosclerosis unknown.
Increased erythrocyte sodium-lithium countertransport (SLC) has been observed in patients with essential hypertension. Consistent evidence of genetic linkage was shown for SLC on chromosome 10, and a region interest localized between 26 56 Mb.This study surveyed single nucleotide polymorphisms (SNPs) 54 genes that reside the interest, investigated their association blood pressure. These SNPs were genotyped 1,133 non-Hispanic white individuals from 255 pedigrees comprising second phase...
Family Medicine Residency Network, Seattle, WA The corresponding author is Sean Turner, MD; [email protected] authors declare no conflicts of interest. opinions and assertions contained herein are those the not to be construed as official or reflecting views US Army Medical Department, at large, Department Defense.
Altered signal intensity in the subcortical white matter on magnetic resonance imaging (MRI) of brain, referred to as leukoaraiosis, arises from ischemic injury due arteriolosclerosis penetrating end arterioles and is associated with increased risk stroke, cognitive decline dementia. Elevated blood pressure (BP) altered diurnal BP rhythm may be major factors.
Restricted accessAbstractFirst published March 2006Cardiovascular Modulation of Dietary Sodium Restriction and β2-Adrenergic Receptor Polymorphism in HumansJ.H. Eisenach, D.R. Schroeder, […], T.L. Pike, C.P. Johnson, W.G. Schrage, E.M. Snyder, B.D. S.T. Turner, M.J. Joyner+6-6View all authors affiliationsVolume 54, Issue 2_supplhttps://doi.org/10.1177/108155890605402s91