A5103060434- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Drug Transport and Resistance Mechanisms
- Diabetes Treatment and Management
- Birth, Development, and Health
- Amino Acid Enzymes and Metabolism
- Metabolism, Diabetes, and Cancer
- Pancreatitis Pathology and Treatment
- Neurological and metabolic disorders
- Adipose Tissue and Metabolism
- Retinal Diseases and Treatments
- Patient Satisfaction in Healthcare
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Retinal Imaging and Analysis
- Telemedicine and Telehealth Implementation
- Reproductive Biology and Fertility
- Chronic Kidney Disease and Diabetes
- Hepatocellular Carcinoma Treatment and Prognosis
- Viral-associated cancers and disorders
- Toxic Organic Pollutants Impact
- Ion Transport and Channel Regulation
- High Altitude and Hypoxia
- Cardiovascular Issues in Pregnancy
- Neurological disorders and treatments
Toranomon Hospital
2008-2020
Inova Fairfax Hospital
2017
Osaka Nishi Clinic
2015
National Defense Medical College
2013
Kurume University
2013
Okinaka Memorial Institute for Medical Research
2008
Kanazawa University
2004-2006
Tokyo Women's Medical University
1998-2004
Kyushu University
2001
Self-Defense Forces Central Hospital
1997
A prospective study based on serial liver biopsies was performed to investigate the efficacy of sodium-glucose cotransporter 2 inhibitor for nonalcoholic fatty disease complicated with type diabetes mellitus. Conclusion: Treatment 24 weeks resulted in improvement histopathologic features all 5 patients. (Hepatology Communications 2017;1:46-52).
The aim of this study was to investigate the therapeutic potential sodium glucose cotransporter 2 inhibitor (SGLT2I) as an effective option for non-alcoholic fatty liver disease (NAFLD).In prospective study, nine patients with NAFLD complicated by type diabetes mellitus (DM), were introduced regimen canagliflozin 100 mg once daily 24 weeks and evaluated histology at pretreatment after start treatment. primary outcome histological improvement, defined a decrease in activity score one point or...
Because early-onset Japanese NIDDM patients (diagnosed before age 30 years) can develop diabetic end-stage renal failure (ESRF) in their thirties, this study was performed to elucidate the incidence and determinants for development of nephropathy.The nephropathy its relationship baseline characteristics long-term metabolic control were determined 426 who followed a mean 6.8 years.Of these patients, 41 developed manifested by persistent proteinuria (incidence rate [95%CI]/1,000 person-years;...
Urinary excretion of cationic xenobiotics is believed to be mediated by organic cation transporter (OCT and OCTN) families expressed on both basolateral brush-border membranes renal tubules, although the molecular mechanisms for targeting these transporters each membrane are poorly understood. Here, examine regulatory cell-surface expression function transporters, we evaluated interaction with several PDZ proteins. A pull-down study using recombinant C-terminal proteins OCTs OCTNs identified...
Although residual beta-cell function delays the onset and progression of diabetic retinopathy in patients with type 1 diabetes, rate destruction is variable.The aim study was to clarify influence on development diabetes.We performed a historical cohort regarding retinopathy.The conducted outpatient clinic general hospital.A total 254 diabetes participated.Serum C-peptide fundus findings were evaluated longitudinally.The cumulative incidence mild nonproliferative higher without detectable...
A part of the organic cation transporter families (OCT3, OCTN1, and OCTN2) has recently been identified to physically interact with PDZ (PSD95, Dlg, ZO1) domain-containing proteins, although physiological relevance such interaction not yet fully examined. Here we have examined stimulatory effect PDZK2 [also named NaPi-Cap2 intestinal kidney-enriched protein (IKEPP)] on those transporters. In HEK293 cells, coexpression increased uptake carnitine by OCTN2 minimal its substrate recognition...
A prospective study based on the serial liver biopsy was performed to investigate efficacy of sodium-glucose co-transporter 2 (SGLT2) inhibitor for NAFLD complicated by type diabetes mellitus. patients were introduced regimen canagliflozin 100 mg once daily 24 weeks, and could be evaluated histology at two points pretreatment weeks after start treatment. In both patients, hepatocyte steatosis grade activity score improved compared pretreatment. Furthermore, physical examination, glucose...
We reported that histological improvement was confirmed after 24 weeks of Canagliflozin (CANA) therapy in nonalcoholic fatty liver disease (NAFLD). While increase the fracture according to CANVAS Program reported. In type 2 diabetes patients with NAFLD (T2ND) who showed by using CANA (100 mg/ day), we investigated bone metabolism markers and body composition (measured an INBODY770) at least 1 year same treatment. The changes parameters (Liver enzymes, serum specific alkaline phosphatase...
Introducing telemedicine in outpatient treatment may improve patient satisfaction and convenience. However, the optimal in-person visit interval for video-based among patients with hypertension remains unreported Japan.We determined hypertension.This was a cluster randomized controlled noninferiority trial. The target sites were 8 clinics Japan that had system, individuals essential hypertension. Among receiving telemedicine, those who underwent visits at 6-month intervals included...
1970年から1987年の間に治癒切除され5年以上追跡された直腸癌375例を対象とし,癌先進部における組織型(先進部組織型)の予後規定因子としての意義にっいて検討した.対象症例の癌巣全体における組織型(主組織型)は高分化37%,中分化54%,低分化4%,粘液5%であったが,先進部組織型はそれぞれ21%,59%,12%,9%であった.先進部組織型が低分化症例は高分化・中分化症例に比べ,肉眼型3型,環周度亜全周以上,壁深達度si(ai),リンパ節転移陽性,脈管侵襲中等度以上のものが高率であり(p<0.02~0.0001),また再発率,生存率が不良であった(いずれもp<0.0001).主組織型が同一であっても,先進部組織型が低い分化度を示す症例は分化度が変化しない症例に比べ生存率が不良であった.また多変量解析の結果,先進部組織型は生存期間に関与したが(p<0.04).主組織型は関与しなかった.以上より先進部組織型は直腸癌の予後規定因子として有用な指標と考えられた.