A5061701492- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Diabetes Management and Research
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Diabetes Management and Education
- Cholesterol and Lipid Metabolism
- Diabetes and associated disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Nutritional Studies and Diet
- Cardiovascular Function and Risk Factors
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Chronic Disease Management Strategies
- Cancer, Lipids, and Metabolism
- Chronic Kidney Disease and Diabetes
- Cardiac Health and Mental Health
- Obesity, Physical Activity, Diet
- Hormonal Regulation and Hypertension
- Antiplatelet Therapy and Cardiovascular Diseases
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Health and Risk Factors
Tokyo Women's Medical University
2015-2024
University of Human Environments
2020-2022
Sugiyama Jogakuen University
2013-2016
Steno Diabetes Centers
2000-2004
To assess the prevalence of non-alcoholic fatty liver disease (NAFLD) and its association with impaired glucose metabolism in Japanese subjects.One thousand, nine hundred fifty subjects enrolled a general health examination programme from September 2002 to February 2003 were recruited. NAFLD was diagnosed if person showed 'fatty liver' on ultrasonography, his/her alcohol consumption, estimated by questionnaire, < 40 gram/week. A linear model used for comparison means metabolic variables...
OBJECTIVE—To report the age- and sex-specific prevalence of diabetes impaired glucose regulation (IGR) according to revised World Health Organization criteria for in Asian populations. RESEARCH DESIGN AND METHODS—We performed 11 studies 4 countries, comprising 24,335 subjects (10,851 men 13,484 women) aged 30–89 years who attended 2-h oral tolerance test met inclusion data analysis. RESULTS—The increased with age reached peak at 70–89 Chinese Japanese but peaked 60–69 followed by a decline...
To provide age- and sex-specific trends, age-standardized projections of diabetes prevalence through the year 2030 in Japanese adult population.In present meta-regression analysis, we included 161,087 adults from six studies nine national health surveys carried out between 1988 2011 Japan. We assessed using a recorded history or, for population individuals without known diabetes, either glycated hemoglobin level ≥6.5% (48 mmol/mol) or 1999 World Health Organization criteria (i.e., fasting...
Objective To examine whether aging itself affects insulin resistance (IR) and secretion in the general Japanese population. Methods This study included data for 2,324 men 1,472 women 30-79 years of age without diabetes who participated a health checkup program. The effects on homeostasis model assessment (HOMA-IR) β-cell function (HOMA-B) were examined using linear regression model. Logistic models used to identify clinical characteristics related age. Multiple analyses stepwise form...
Context: Dyslipidemia coexists with hyperglycemia. However, little is known about the ethnic differences in lipid profiles at comparable glucose tolerance status. Objective: The aim was to study stratified by levels. Design and Setting: Data from 31 cohorts of 12 countries, consisting 24,760 men 27,595 women aged 25–74 yr, were compared. odds ratio for having dyslipidemia estimated each group categories. Results: Compared central northern Europeans, multivariable adjusted ratios (95%...
To determine whether specific lipid parameters are better predictors of cardiovascular disease (CVD) in Japanese mild-to-moderate hypercholesterolemic patients with and without diabetes.Mildly or moderately no history CVD received diet therapy plus pravastatin. In this post-hoc subanalysis, 5-year data from 3170 (668 diabetes, 2502 non-diabetes) on alone were used to compare as CVD. We examined the by tertiles, using hazard ratio (HR) per one-standard deviation (SD) increment (decrease for...
Serum levels of cholesterol absorption and synthesis markers have been associated with cardiovascular risk in the United States European countries. In this study, we examined relevance these biomarkers presence disease (CVD) Japanese individuals.The CACHE consortium, comprising 13 research groups Japan possessing data on campesterol, an marker, lathosterol, a marker measured by gas chromatography, compiled clinical using REDCap system.Among 2,944 individuals population, those missing...
Although the ADA/EASD/IDF International Expert Committee recommends using hemoglobin A1c (HbA1c) to define diabetes, relation between HbA1c and cardiovascular disease (CVD) has not been thoroughly investigated. We analyzed this clinical data on Japanese individuals with hypercholesterolemia. In large-scale MEGA Study 7832 patients aged 40 70 years old mild-to-moderate hypercholesterolemia without CVD were randomized diet alone or plus pravastatin followed for >5 years. present subanalysis of...
Abstract This study aimed to develop a reliable and valid measure of functional health literacy in J apanese clinical setting. Test development consisted three phases: generation an item pool, consultation with experts assess content validity, comparison external criteria (the H ealth K nowledge T est) criterion validity. A trial version the test was administered 535 outpatients. Internal consistency reliability, calculated by C ronbach's alpha, 0.81, concurrent validity moderate. R eceiver...
Serum levels of cholesterol absorption and synthesis markers are known to be associated with cardiovascular risk. Individuals reduced kidney function or chronic disease (CKD) at an increased risk for disease. Hence, we examined the relationship between estimated glomerular filtration rate (eGFR) serum synthesis.
We investigated the predictive value of changes in serum gamma-glutamyltransferase (GGT) for development cardiovascular disease (CVD) risk factors Japanese.A total 1514 adult participants a general health examination program were followed 3 years until January, 2006. The subjects divided into two groups according to whether their GGT level had decreased (< or =0 U/L) increased (> =1 from baseline during study period. logistic regression model was used analyze relationship between increases...
Age is associated with both impaired glucose and insulin metabolism. To what extent the age-related changes in resistance (IR) beta-cell function contribute to increase prevalence of fasting (IFG) tolerance (IGT) less known, this investigated study.This study included 6610 men 7664 women different ethnic groups aged 30-69 years. IR were examined by homeostasis model assessment (HOMA-IR) (HOMA-B). Odds ratios (ORs) 95% confidence intervals (95% CIs) estimated using logistic regression...
To examine glycemic control for the prevention of retinopathy in early diagnosed Japanese NIDDM patients.There were 137 patients with but without who first visited our facility from 1983-1985. Their age at diagnosis ranged 30-65 years, a disease duration < 3 years. The optic fundi examined least annually. prevalence 10th year after registration study was compared four groups stratified by mean HbA1c values 10 Multiple logistic regression analysis used to assess relationship between and...