A5080870194- Pancreatic and Hepatic Oncology Research
- Single-cell and spatial transcriptomics
- Inflammasome and immune disorders
- Immune cells in cancer
- Gut microbiota and health
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- HVDC Systems and Fault Protection
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Biomarkers in Disease Mechanisms
- Renal cell carcinoma treatment
- Neuroendocrine Tumor Research Advances
- Cancer Research and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Bacteriophages and microbial interactions
- Extracellular vesicles in disease
- Fatigue and fracture mechanics
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
Shanxi Medical University
2025
Second Hospital of Shanxi Medical University
2025
Sichuan University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Yangtze University
2024
State Key Laboratory of Biotherapy
2022-2023
National Clinical Research Center for Digestive Diseases
2023
Abstract Breast cancer can metastasize to various organs, including the lungs. The immune microenvironment of organs be metastasized plays a crucial role in metastasis breast cancer. Infection with pathogens such as viruses and bacteria alter status lung. However, effect chronic inflammation caused by on formation premetastatic niche within lung is unclear, contribution specific mediators tumor also remains largely undetermined. Here, we used mouse model revealing that pulmonary bacterial...
miRNA has emerged as a crucial regulator in various of pathological and physiological processes, yet its precise mechanism action the detailed their Head neck squamous cell carcinoma (HNSCC) remains incompletely understood. This study sheds light on role mi-151-5p, revealing significantly elevated expression tumor cells, which notably enhances invasion migration HNSCC cells. effect is achieved through directly targeting LY6/PLAUR Domain Containing 3 (LYPD3) by miR-151-5p, involving...
Previous studies have demonstrated that silica can activate the NLRP3 inflammasome, and macrophage phagocytosis is an essential step in this process. Although carbon primary component of coal dust particles, it also contains other impurities such as free silica, clay, sulfides, carbonate minerals. Additional research still necessary to discover if be triggered due low content particles. The purpose study investigate whether particles induce translation transcription inflammasome components...
Knowledge of the changes in immune microenvironment during pulmonary bacterial acute and chronic infections is limited. The dissection system may provide a basis for effective therapeutic strategies against infection. Here, we describe single cell atlas mouse lungs after
Pancreatic adenocarcinoma, a malignancy that arises in the cells of pancreas, is devastating disease with unclear etiology and often poor prognosis. Locally advanced pancreatic cancer, stage where tumor has grown significantly but not yet spread to distant organs, presents unique challenges treatment. This article aims discuss current strategies, challenges, future directions management locally adenocarcinoma (LAPC).
Manganese ion (Mn
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor prognosis. When it metastasizes to the liver, treatment options become particularly limited and challenging. Current for liver metastatic PDAC are limited, chemotherapy alone often proves insufficient. Immunotherapy, programmed cell death 1 (PD-1) inhibitors like sintilimab, shows potential efficacy various cancers but has reports on PDAC. This study compares safety of sintilimab plus S-1 gemcitabine vs in To...
Abstract Background: Head and neck squamous cell cancer (HNSCC) is the most prevalent head malignancy. Chemoresistance a major challenge in treatment of advanced HNSCC. Circular RNAs (circRNAs) are essential for development chemoresistance. The role mechanism circRNAs regulation HNSCC chemoresistance much less explored. Methods: CircRNA microarray analysis was used to detect differentially expressed expression circTPST2 miRNAs cells assessed by qPCR, ring structure examined using Sanger...
Background: Knowledge of the changes in immune microenvironment during pulmonary bacterial acute and chronic infections is limited. The dissection systems may provide a basis for effective therapeutic strategies against infection.Methods: Using single-cell transcriptomics, mIHC flow cytometry, we revealed large-scale comprehensive cell composition high variation cell–cell interactions after Pseudomonas aeruginosa infection.Findings: Bacterial infection reprograms genetic architecture...