A5067350353- Noise Effects and Management
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Studies
- Breast Lesions and Carcinomas
- Pneumonia and Respiratory Infections
- Anomaly Detection Techniques and Applications
- COVID-19 diagnosis using AI
- Influenza Virus Research Studies
- Hearing Loss and Rehabilitation
- Hepatocellular Carcinoma Treatment and Prognosis
- Physiological and biochemical adaptations
- Multiple Myeloma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- MRI in cancer diagnosis
- RNA and protein synthesis mechanisms
- Vestibular and auditory disorders
- Neurobiology and Insect Physiology Research
- Neural dynamics and brain function
- AI in cancer detection
- Acoustic Wave Phenomena Research
- Magnesium Alloys: Properties and Applications
- Poxvirus research and outbreaks
- Galectins and Cancer Biology
Hefei Institute of Technology Innovation
2022-2024
RayBiotech (United States)
2021-2023
Tsinghua University
2023
Peking University
2005-2022
Peking University People's Hospital
2021-2022
Emory University
2001-2016
Creative Research Enterprises (United States)
2016
Fourth People's Hospital of Sichuan Province
2016
Peking Union Medical College Hospital
2014
Chinese Academy of Medical Sciences & Peking Union Medical College
2014
Copy number variations (CNVs) are the major type of structural variation in human genome, and more common than DNA sequence populations. CNVs important factors for genetic phenotypic diversity. Many have been associated with either resistance to diseases or identified as cause diseases. Currently little is known about role causing deafness. currently not analyzed by conventional analysis methods study Here we detected both affecting 80 genes be required normal hearing.Coding regions deafness...
AIM:To determine whether contrast-enhanced ultrasound (CEUS) can improve the precision of breast imaging reporting and data system (BI-RADS) categorization. METHODS:A total 230 patients with 235 solid lesions classified as BI-RADS 4 on conventional were evaluated.CEUS was performed within one week before core needle biopsy or surgical resection a revised classification assigned based 10 CEUS characteristics.Receiver operating characteristic curve analysis then conducted to evaluate...
Genetic factors play an important role in hearing loss, contributing to approximately 60 % of cases congenital loss. Autosomal dominant deafness accounts for 20 hereditary Diseases with autosomal inheritance often show pleiotropy, different degrees penetrance, and variable expressivity. A three-generation Chinese family nonsyndromic impairment (ADNSHI) was enrolled this study. Audiometric data blood samples were collected from the family. In total, 129 known human genes sequenced using...
AIM:To build and evaluate predictive models for contrast-enhanced ultrasound (CEUS) of the breast to distinguish between benign malignant lesions. METHODS:A total 235 imaging reporting data system (BI-RADS) 4 solid lesions were imaged June 28, 2016|Volume 8|Issue 6| WJR|www.wjgnet.comLuo J et al .Predictive model CEUS 86.46%, 81.29% 83.40%, respectively. CONCLUSION:The can predict risk more accurately, decrease false-positive biopsy, provide accurate BI-RADS classification.
The authors aimed to evaluate traffic noise level and annoyance in Beijing the impact of on quality life residences. performed a cross-sectional study 12-floor college dormitory near 4th Ring Road Beijing, China. north-side rooms building were noisy had windows facing road. measured both indoor outdoor noise. Using 5-item verbal scale 0-10 numerical scale, they questioned sample 1,293 students living about road-traffic annoyance. results showed that average day-to-night was 79.2 dB(A) 64.0...
The authors applied noise exposure and audiometry information collected on 156 Chinese textile workers to develop a method of identifying individuals susceptible noise-induced hearing loss. They estimated threshold shift (NIHTS) by averaging the adjusted thresholds at 3, 4, 6 kHz both ears, they fitted quadratic model describe dose-response relationship between cumulative NIHTS. residual actual NIHTS model-predicted indicated susceptibility. A comparison 20% subjects with greatest residuals...
Anomaly detection (AD) in medical images aims to recognize test-time abnormal inputs according normal samples the training set. Knowledge distillation based on teacher-student (T-S) model is a simple and effective method identify anomalies, yet its efficacy constrained by similarity between teacher student network architectures. To address this problem, paper, we propose T-S with skip connections (Skip-TS) which trained direct reverse knowledge (DRKD) for AD images. First, overcome low...
Usher syndrome is an autosomal recessive disease characterized by sensorineural hearing loss, age-dependent retinitis pigmentosa (RP), and occasionally vestibular dysfunction. The most severe form type 1 (USH1). Mutations in the MYO7A gene are responsible for USH1 account 29–55% of cases. Here, we a Chinese family (no. 7162) with USH1. Combining targeted capture 131 known deafness genes, next-generation sequencing, bioinformatic analysis, identified two deleterious compound heterozygous...
Objective To build breast contrast-enhanced ultrasound (CEUS) predictive models of benign and malignant lesions, evaluate its value in risk assessment. Methods Breast CEUS lesions was depending on the analysis published papers, conclusion previous study results clinical experience. With final pathology as gold standard, evaluated totally 235 nodules which were classified imaging reporting data system (BI-RADS) 4. Results There 139 (59.2%) 96 (40.8%) this study. Diagnostic...
Aim: Streptococcus pneumoniae and influenza H1N1 virus are common organisms associated with human infections. These infections could play a significant role in immune regulation. The study was performed to analyse the genome sequences of these its functional significance. Methods: overlapping Influenza (H1N1) against by BLASTn sequence analysis. alignments studied corresponding genes for their significance DAVID NDEx software.Results: Several hits or nucleotide segments were identified....
Tongue diagnosis is widely used in traditional Chinese medicine diagnosis. The classification of tongue coating thickness one the most important tasks However, data imbalance imposes challenges when using deep learning methods for classification. In this paper, we propose a augmentation method image-to-image translation to solve problem. First, use an model based on generative adversarial networks (GANs) translate thick and thin images into each other, then train synthetic together with real...
Liver derived messenger ribonucleic acid (mRNA) transcripts were reported to be elevated in the circulation of hepatocellular carcinoma (HCC) patients. We now report detection high-risk mRNA variants exclusively HCC Numerous genomic alleles such as single nucleotide polymorphisms (SNPs), insertions and deletions (called Indels), splicing many genes, have been associated with risk cancer. Our findings potentially offer a novel non-invasive platform for surveillance early detection.
Background Controversies on the safety of cement application between cemented and uncemented total hip arthroplasty (THA) have been existing for decades. The purpose this study was to observe changes in mean arterial pressure (MAP), heart rate (HR) oxygen (PaO 2 ) during THA, evaluate intraoperative using third-generation cementing technique investigate whether risk is higher acute femoral neck fracture patients than non-traumatic patients. Methods Forty-two who underwent THA November 2005...
Objective: To investigate the interference of daratumumab on immunofixation electrophoresis after treating plasma cell diseases and methods to eliminate interference. Methods: Serum samples eight patients with treated in Peking University People's Hospital from April 2020 March 2021 were collected for standard Hydrashift 2/4 assay. Results: After treatment, 81.3% (13/16) showed drug-induced monoclonal antibodies (IgG-κ) . The without bands related individual differences, administration...