A5011678936- Peroxisome Proliferator-Activated Receptors
- Erythrocyte Function and Pathophysiology
- Immune Response and Inflammation
- Streptococcal Infections and Treatments
- Circadian rhythm and melatonin
- Muscle Physiology and Disorders
- Laser Applications in Dentistry and Medicine
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Spaceflight effects on biology
- Extracellular vesicles in disease
- FOXO transcription factor regulation
- Mesenchymal stem cell research
- Oral microbiology and periodontitis research
- Histone Deacetylase Inhibitors Research
- Genomics, phytochemicals, and oxidative stress
- Oral Health Pathology and Treatment
- Periodontal Regeneration and Treatments
- Liver Disease Diagnosis and Treatment
- Wound Healing and Treatments
- Cellular Mechanics and Interactions
Guangzhou University of Chinese Medicine
2025
China Pharmaceutical University
2024-2025
Wuhan University
2023-2024
Huazhong University of Science and Technology
2012-2024
Hubei Zhongshan Hospital
2023-2024
Union Hospital
2022-2024
Union Hospital
2023
Abstract Macrophages play a pivotal role in the immunological cascade activated response to biomedical implants, which predetermine acceptance or rejection of implants by host via pro‐ and anti‐inflammatory polarisation states. The chemical signals macrophage is well‐established, but how physical cues regulate function that may fundamental implant‐bone interface, remains poorly understood. Here we find bone marrow‐derived macrophages (BMDM) cultured on polyacrylamide gels varying stiffness...
Abstract Bone regeneration remains a great clinical challenge. Low intensity near-infrared (NIR) light showed strong potential to promote tissue regeneration, offering promising strategy for bone defect regeneration. However, the effect and underlying mechanism of NIR on remain unclear. We demonstrated that in rat skull model was significantly accelerated with low-intensity stimulation. In vitro studies stimulation could osteoblast differentiation mesenchymal stem cells (BMSCs) MC3T3-E1...
Abstract Metabolic-dysfunction-associated steatotic liver disease is one of the most common chronic diseases worldwide and has no approved treatment thus far. Here we report that hepatic overexpression Gm35585, a novel lncRNA downregulated in livers mice fed high-fat diet, functionally important alleviating lipid accumulation pathologies. Gm35585 activates peroxisome proliferator-activated receptor α (PPARα) signaling pathway promotes expression downstream PPARα-target gene, enoyl-CoA...
Dental pulp stem cells (DPSCs) have the potential to form bone, nerve and fat, are a candidate for use in regenerative medicine. Previous studies indicated that total flavonoids from Drynaria fortunei show stimulative effect on proliferation osteogenic differentiation of osteoblastic MC3T3-E1 vitro. This study aimed investigate rat DPSCs, further clarify mechanisms involved. DPSCs were isolated by enzymatic digestion identified using CD44, CD29 CD34 markers immunohistochemistry, exposed...
Duchenne muscular dystrophy (DMD) is an X-linked recessive progressive degenerative disease of skeletal muscle, characterized by intramuscular inflammation, muscle regeneration disorder and replacement with fibroadipose tissue. DMD caused the absence normal dystrophy. Impaired self-renew ability limited differentiation capacity satellite cells are proved as main reasons for failure. The deficiency estrogen impedes process regeneration. However, role receptor β (ERβ) in still unclear. This...