A5082334771- Lung Cancer Treatments and Mutations
- Animal Virus Infections Studies
- Prostate Cancer Treatment and Research
- Telomeres, Telomerase, and Senescence
- Adipokines, Inflammation, and Metabolic Diseases
- Chronic Lymphocytic Leukemia Research
- Mangiferin and Mango Extracts
- PARP inhibition in cancer therapy
- Viral Infections and Immunology Research
- Tea Polyphenols and Effects
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Esophageal Cancer Research and Treatment
- interferon and immune responses
- Clusterin in disease pathology
- Polysaccharides and Plant Cell Walls
- Phytochemicals and Medicinal Plants
- Agriculture and Biological Studies
- MicroRNA in disease regulation
- Bioactive Compounds and Antitumor Agents
- Cancer, Lipids, and Metabolism
- Healthcare and Venom Research
First Affiliated Hospital of Xi'an Jiaotong University
2025
Soochow University
2023
First Affiliated Hospital of Anhui Medical University
2021-2022
Anhui Medical University
2021-2022
Inner Mongolia Medical University
2015-2021
Xinyang Central Hospital
2021
Linyi People's Hospital
2019
Chongqing University of Education
2015
Sun Yat-sen University
2014
Sun Yat-sen University Cancer Center
2014
Adiponectin (ADN) regulates DNA synthesis, cell apoptosis and cycle to participate in the pathology progression of glioblastoma. The present study aimed further explore effect ADN on temozolomide (TMZ) resistance glioblastoma underlying mechanism action. Glioblastoma lines (U251 U87‑MG cells) were treated with TMZ at different concentrations; subsequently, 3.0 µg/ml 1.0 mM selected as optimal concentrations for experimental conditions. LY294002 (a PI3K inhibitor) was added or + TMZ‑treated...
BACKGROUND The aim of this study was to investigate the effects TNF-α and IL-10 on expression ICAM-1 CD31 in human coronary artery endothelial cells (HCAEC). MATERIAL AND METHODS HCAEC treated with 0, 2.5 μg/l, 5 10 μg/l for 2 h, 6 0 100 200 h 15 respectively. RNA inference TNF-αR performed siRNA. Real-time PCR, Western blot analysis, ELSA were used detect mRNA level protein CD31. RESULTS significantly increased (P<0.05), had most obvious effect. RNAi TNF-aR reduced induction (P<0.05)....
Leucine-rich-alpha-2-glycoprotein1 (LRG1) is a new oncogene-related gene, which has been proven important for the development and poor prognosis of human cancers. However, whether it participates in esophageal squamous cell carcinoma (ESCC) progression remains unclear.To investigate expression level functional influence LRG1 ESCC.The was evaluated on mRNA protein ESCC patients. Then, correlation with clinicpathological variables analyzed ESCC. Besides, to clarify biological function LRG1,...
As a significant overlap of 11C-Choline standardized uptake value (SUV) between prostate cancer and benign hyperplasia (BPH) tissue, controversy exists regarding the clinical PET/CT scan in primary cancer. In this study, SUVmax lesions pelvic muscles were measured their ratios (SUVmax-P/M ratio) calculated. Then we evaluated whether tracer uptake, quantified as SUVmax-P/M ratio, correlated with tumour stage, Gleason score, expression levels several biomarkers aggressiveness.Twenty-six...
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. The mechanisms underlying NSCLC initiation and progression require further investigation. purpose this study was to investigate role ADP ribosylation factor-like GTPase 14 (ARL14) related NSCLC.We analyzed correlation between clinical characteristics ARL14 expression using data from Cancer Genome Atlas (TCGA). Kaplan-Meier analysis conducted evaluate prognostic value in NSCLC. Functions were...
Insect tea is a traditional and special in China. After the HepG2 cancer cells were treated with insect ethanol extracts (ITEE) for 48 h, cell proliferation was inhibited, 40, 80 160 μg/mL of ITEE showing inhibitory rates 35.1%, 59.7% 86.3%, respectively. Compared to lower concentration, significantly induced apoptosis as determined by flow cytometry analysis, which showed content sub-G1 38.8%. By RT-PCR, increasing caspase-3, caspase-8, caspase-9, Bax, p53, p21, E2F1, p73 decreasing Bcl-2,...
The current study was designed to evaluate the aqueous extract of Terminalia chebula activity, and main pathway detected on lung cancer by extracts T. chebula. Aqueous separated using a zeolite, five fractions were obtained analyzed ultraviolet (UV) infrared (IR) spectroscopy. Antiproliferative activity evaluated 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) methods against human (A549) mouse cell line LLC. acts regulating Bcl-2 family protein-mediated mitochondrial...
To investigate the expression of CD44v6 in stage T2-3N0M0 esophageal squamous cell carcinoma (ESCC) and its prognostic significance.The a series 227 ESCC specimens was evaluated by immunohistochemistry (IHC). A reproducible semiquantitative method which took both staining percentage intensity into account applied for IHC scoring, receiver operating characteristic (ROC) curve analysis utilized to select cut-off score high or low reactivity. Then, correlations with clinicopathological features...
To study the effect of Cynomorium songaricum polysaccharide (CSRP) on A549 cells telomere human non-small cell lung cancer, mice were intragastric administrated with CSRP (0.08 g•kg⁻¹) once daily for 4 days. Then their serum was taken preparing drug serum. treated by serum, and different concentrations treating time proliferation cancer determined MTT test. After 48 hours concentrations, length fluorescence quantitative polymerase chain reaction (qPCR); mRNA expression telomerase reverse...
Background: Lymphocyte telomere length (LTL) is associated with tumor prognosis, and TL-related single-nucleotide polymorphisms (SNPs) may affect the recurrence of non-oropharyngeal squamous cell carcinoma (SCCNOP).Methods: A total 1403 SCCNOP patients were recruited genotyped for 16 SNPs identified by a genome-wide association study. Univariate multivariate analyses performed to evaluate associations between recurrence.Findings: Patients carrying rs755017 GA/GG, rs248799 TC/TT, rs2736108 or...
Although potato extract, derived from various methods, exhibits anticancer, antiviral and anti-parasite activities in vitro vivo, the bioactivity of solution remains unclear using freeze-thaw extraction method granted by State Intellectual Property Office China. In present study, a (PFTS) was fed to mice with ascites tumor that were pre-treated cyclophosphamide. The numbers peripheral white blood cells (WBCs), macrophage phagocytosis, lymphocyte transformation survival measured. While...
Objective To study the effects of Phellodendron amurense on herpes simplex virus 1 (HSV-1) and cytokines, to explore mechanism inhibiting HSV-1 through multiple channels. Methods Viruses were inoculated into medicine treated HeLa cells. The proliferation was observed by fluorescence microscopy. transcriptional levels glycoprotein gD functional protein US1 surface envelope detected quantitative (q) PCR. After incubating cells for 24 h, qPCR used detect expression intrinsic immune...