The helix-loop-helix (HLH) protein Id lacks the basic DNA-binding domain common to this class of proteins. In vitro experiments suggested that could associate tightly with two other HLH proteins encoded by E2A gene, E12 and E47 (referred here collectively as E proteins) prevent their binding a sequence present in muscle creatine kinase (MCK) enhancer either homo-oligomers or hetero-oligomers MyoD. report we evidence for vivo roles proteins: (1) co-fractionate co-immunoprecipitate whole-cell...

Cranial nerve palsy is a rare complication after patients with nasopharyngeal carcinoma (NPC) receive radiotherapy using technique that delivers 180-200 centigrays (cGy) per day. neuropathy of particular clinical interest in terms making differential diagnosis, because it also common presenting manifestation NPC. may lead to distressing signs and symptoms these patients, their treatment has not been addressed previous reports. This article presents the authors' experience...

In our clinical practice, we have observed a high incidence of locoregional failure in squamous cell carcinoma (SCC) the buccal mucosa. We analyze treatment results this cancer and compare these with those literature. intend to define pattern provide information for design better multimodality treatment.During period from 1983 through 2003, 121 previously untreated patients M0 stage SCC mucosa were treated curative intent at hospital. Twenty-seven received surgery alone, 36 had radiotherapy...

Vocal cord paralysis (VCP) is a sign of certain underlying disease, diagnosis which can be attributed to various causes. This study intends analyze the contemporary etiology VCP in tertiary medical center.A retrospective review records from June 2000 December 2004 hospitalized patients with was done determine etiology.Two hundred and ninety-one determined were identified, consisting 176 males 115 females. Unilateral present 259 patients, while 32 presented bilateral VCP. The causes surgical...

AbstractSorafenib (Nexavar, BAY43-9006), a bi-arylurea, is newly established anti- cancer drug and its functional attribute of cytotoxicity based on the multi- kinase inhibitory action. Here, we report yet another novel pathway in which sorafenib can induce apoptotic cell death preferentially efficaciously an experimentally proven drug- radio-resistant human Hep G2 cells via mitochondria-dependent oxidative stress mechanism. A real time confocal imaging assay revealed that could rapidly...

Patients with hepatocellular carcinoma (HCC) often have unresectable tumors. Transcatheter arterial chemoembolization (TACE) is one of the limited alternative treatments that can prolong these patients' survival. However, presence portal vein tumor thrombosis (PVTT) a contraindication for TACE and, therefore, HCC patients PVTT would be depleted advantage TACE. The purpose this study was to analyze recanalization rate thrombosed and treatment toxicities after stereotactic radiotherapy (SRT)...

This article reports the epidemiological characteristics and possible contributing etiology of oral cavity cancer in Taiwan. Data on from period between 1986 1997 were compiled Taiwan Cancer Registry Annual Report. The amount average annual consumption per person cigarettes, alcohol betel nut extracted Report Tobacco Wine Monopoly Bureau Agriculture Counsel incidence increased annually. Both total male have substantially since 1993. Regarding peak incidence, most cases seen sixth to eighth...

Objective . This study assessed the posttreatment tumor control and auditory function of vestibular schwannoma (VS) patients after CyberKnife (CK) analyzed possible prognostic factors hearing loss. Methods We retrospectively studied 117 VS patients, with Gardner-Robertson (GR) classification grades I to IV, who underwent CK between 2006 2012. Data including radiosurgery treatment parameters, pre- postoperative size, were collected examined. Results With CK, had excellent rates (99.1%), a...

Survival in patients with locally advanced unresectable pancreatic cancer (LAUPC) is poor, and local recurrence continues to be a major problem the management of this disease. Radiotherapy (RT) using different RT techniques, including intensity-modulated radiotherapy (IMRT) stereotactic body radiation therapy (SBRT), may lead clinical outcomes for LAUPC. Here, we compared SBRT IMRT LAUPC respect survival rate, control (LC) toxicity-related dose distribution.This retrospective study from...

To analyze the rate of larynx preservation in patients locally advanced hypopharyngeal cancer treated with intensity modulated radiotherapy (IMRT) plus concurrent chemotherapy, and compare results primary surgery.Between January 2003 November 2007, 14 were surgery 33 chemoradiotherapy (CCRT) using IMRT technique. Survival rate, calculated Kaplan-Meier method. Multivariate analysis was conducted for significant prognostic factors Cox-regression method.The median follow-up 19.4 months all...

The aim of this study was to compare high-dose volumetric modulated arc therapy (VMAT) and fixed-field intensity-modulated radiotherapy (ff-IMRT) plans for the treatment patients with middle-thoracic esophageal cancer. Eight cT2-3N0M0 cancer were enrolled. planning system version 9 Pinnacle3 SmartArc (Philips Healthcare, Fitchburg, WI, USA). VMAT ff-IMRT generated each case, both techniques used deliver 50 Gy target volume (PTV50) then provided a 16-Gy boost (PTV66). superior PTV66 coverage...

To concurrently quantify the radiation-induced changes and temporal evolutions of parotid volume apparent diffusion coefficient (ADC) in nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiotherapy using magnetic resonance imaging (MRI).A total 11 NPC (9 men 2 women; 48.7 ± 11.7 years, 22 glands) were enrolled. Radiation dose, sparing volume, severity xerostomia, radiation-to-MR interval (RMI) was recorded. MRI studies acquired four times, including one before three...

Objectives We reported the contemporary survival outcome of patients with nasopharyngeal carcinoma (NPC) and analysed factors affecting survival. Design A retrospective cohort study. Setting nationwide population‐based study in Taiwan. Participants identified 13 407 newly diagnosed NPC from 2002 to 2010. Material Methods The multivariate Cox proportional hazards model was performed measure mortality‐association risk factor after adjusting for treatment socio‐demographic characteristics....

Curative-intent radiotherapy for multiple lung metastases with more than 10 lesions is limited by dose constraints and respiratory motion. Carbon ion (CIRT) leverages the Bragg peak precision hypofractionation, while high-frequency oscillatory ventilation (HFOV) minimizes motion under anesthesia. This study evaluates feasibility of combining CIRT HFOV in treating ≥15 metastases. Two patients received single-fraction (50 Gy(RBE)) targeting all lesions. Case 1 (16 bilateral lung,...

The molecular mechanisms behind the aggressiveness of nasopharyngeal carcinoma (NPC), a highly invasive and metastatic head neck malignancy, have not been made clear. In this study investigating these mechanisms, guanine nucleotide-binding protein alpha(12) subunit (G(alpha)(12)) signaling was found by microarray analysis to be increased in primary NPC cells NPC-derived cell lines. Using small interfering RNA knock down G(alpha)(12) resulted reduction migration invasion as well reversal...

The application of stereotactic ablative radiotherapy (SABR) to hepatocellular carcinoma (HCC) is emerging. To identify pretreatment prognostic indicators crucial for patient selection and optimal individual therapy. aim this study was determine whether ¹⁸F-FDG PET a combined ¹⁸F-FDG–contrast CT parameter could be useful tools predict tumor control patients with HCC treated by SABR. <b>Methods:</b> We retrospectively identified 31 (41 tumors) who underwent before SABR...

The treatment of renal cell carcinoma (RCC) in patients diagnosed with chronic kidney disease (CKD) requires particular care order to preserve the remaining function. present study aimed investigate potential a novel nephron‑sparing treatment, which is capable targeting tumors embedded deep within tissues. analyzed three patients, pre‑existing CKD and multiple comorbidities, who were successfully treated for stage I RCC using CyberKnife® stereotactic ablative radiotherapy (SABR) system....

To evaluate the experience of induction chemotherapy followed by concurrent chemoradiationwith helical tomotherapy (HT) for nasopharyngeal carcinoma (NPC).Between August 2006 and December 2009, 28 patients with pathological proven nonmetastatic NPC were enrolled. All staged as IIB-IVB. Patients first treated 2 to 3 cycles EP-HDFL (Epirubicin, Cisplatin, 5-FU, Leucovorin). After chemotherapy, weekly based PFL was administered HT. Radiation consisted 70 Gy planning target volumes primary tumor...

The role of stereotactic ablative radiotherapy (SABR) in patients with hepatocellular carcinoma (HCC) who are refractory to or unsuitable for transarterial chemoembolization remains unclear. We examined the efficacy and safety Cyberknife SABR its effect on survival this group HCC patients.From June 2008 2011, 53 68 tumors unresectable were treated using SABR. measured 1.1-13 cm (median, 4.3 cm). median prescribed dose was 40 Gy four five fractions over 4-5 consecutive working days.The...