A5100599975- Eicosanoids and Hypertension Pharmacology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peroxisome Proliferator-Activated Receptors
- Advanced Glycation End Products research
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Microbial infections and disease research
- Antioxidant Activity and Oxidative Stress
- Acute Kidney Injury Research
- Cancer, Hypoxia, and Metabolism
- Cholesterol and Lipid Metabolism
- Kruppel-like factors research
- Aquaculture disease management and microbiota
- Sphingolipid Metabolism and Signaling
- S100 Proteins and Annexins
- Cancer-related molecular mechanisms research
- Reproductive tract infections research
- Metallurgical Processes and Thermodynamics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Pesticide Exposure and Toxicity
- Acupuncture Treatment Research Studies
- Natural Antidiabetic Agents Studies
- Chronic Kidney Disease and Diabetes
Fujian Medical University
2019-2024
China Metallurgical Planning Net (China)
2022-2024
Yangzhou University
2021-2024
Ministry of Agriculture and Rural Affairs
2024
Shanghai University of Traditional Chinese Medicine
2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2024
Fujian Provincial Hospital
2019-2024
China Agricultural University
2024
South China University of Technology
2021-2024
Guangzhou Medical University
2021-2024
Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading increased permeability. Current treatments of IBD primarily address neglecting epithelial repair. Our previous study has reported therapeutic potential notoginsenoside R1 (NGR1), a characteristic saponin from root Panax notoginseng, in alleviating acute colitis reducing mucosal inflammation. In this we investigated reparative effects NGR1 on after injury stage...
Abstract Maturing immunometabolic research empowers immune regulation novel approaches. Progressive metabolic adaptation of tumor cells permits a thriving microenvironment (TME) in which always lose the initial killing capacity, remains an unsolved dilemma even with development checkpoint therapies. In recent years, many studies on immunometabolism have been reported. The may facilitate anti-tumor immunotherapy from recurrent crosstalk between metabolism and immunity. Here, we discuss...
β-Asarone, an active component of the Acori graminei rhizome that has been used as traditional Chinese herb, reported to be capable inhibiting neuronal apoptosis. However, signaling mechanism underlying inhibitory effect β-asarone remained elusive. This study was aimed investigate whether CaMKII pathway is involved in mediated neuroprotection. Using PC12 cells and primary cultures cortical neurons treated with amyloid-β (Aβ)(1-40) or Aβ(1-42) peptide, we demonstrated can protect inhibit...
Abstract Background Dysfunctional high-density lipoprotein (HDL) may have pro-inflammatory effects on the endothelial cells,which causes atherosclerosis in type 2 diabetes mellitus (T2DM). HDL is a major carrier of sphingosine-1-phosphate (S1P) plasma while S1P exhibits multiple biological activities. However, potential role and T2DM remains unexplored. We hypothesized that diabetic with higher contents exerts beneficial vascular system. Methods Subjects or without proved large arteries...
Abstract Epidemiological studies suggested complicated associations between type 2 diabetes mellitus and breast cancer. There is a significant inverse association high‐density lipoprotein (HDL) the risk mortality of However, HDL could be modified in various ways patients, this may lead to altered effects on many different types cells. In our study, we found that glycation oxidation levels are significantly higher from patients compared healthy subjects. Diabetic dramatically had stronger...
Abstract Aims/hypothesis In type 2 diabetes mellitus (T2DM), the abnormal protein and lipid composition of diabetic high‐density lipoprotein (HDL) could impair its anti‐inflammatory functions. Whether nonenzymatic glycation directly impaired effects HDL in innate immunity remained unclear. Methods Human acute monocytic leukemia cell line (THP‐1) cells, mouse RAW 264.7 macrophages primary human monocytes derived were pre‐incubated with native HDL, isolated from T2DM patients or glycated...
High-density lipoprotein (HDL) can induce cyclooxygenase-2 (COX-2) expression and prostacyclin I-2 (PGI-2) release in endothelial cells to exert multiple antiatherogenic functions. This effect has been attributed mainly the role of sphingosine-1-phosphate (S1P) integrated HDL. However, whether apolipoprotein A-I (apoA-I), major HDL, could COX-2 PGI-2 still remains unclear. In present study, we selectively delipidated HDL confirmed that apoA-I facilitate production human umbilical vein...
Family members of peroxisome proliferator-activated receptors (PPARs), such as PPARγ, have been shown to be effective in regulating T helper 17 (Th17) cell differentiation. However, whether PPARα, another important family member PPARs, contributes Th17 differentiation remains controversial. In the present study, we show that PPARα may a negative regulator CD4+ cells from knockout mice, deficiency enhances IL-17 and IL-6 levels promotes contrast, wild type activation suppresses Furthermore,...
The aim of the current study was to investigate regulatory effect sericin on hepatic insulin‑phosphoinositide 3‑kinase (PI3K)/protein kinase B (AKT) signaling pathway in a type 2 diabetes rat model. Male Sprague Dawley rats were randomly divided into four groups: Control group, diabetic model high‑dose group and low‑dose with 12 each group. Fasting blood glucose detected by oxidase method, glycogen determined periodic acid‑Schiff staining. morphology liver observed hematoxylin eosin...
Purpose Based on resource-based theory and intellectual capital theory, this paper aims to investigate the impact of digital investment enterprise value mediating role capital. Additionally, it explores heterogeneous impacts Design/methodology/approach The study utilizes a sample listed companies in Chinese A-shares from 2013 2020. entropy-weighted method is applied measure two dimensions: scale increment. Finally, research hypotheses are tested through multiple regression analysis. Findings...
Diabetic HDL had diminished capacity to stimulate endothelial cell (EC) proliferation, migration, and adhesion extracellular matrix. The mechanism of such dysfunction is poorly understood we therefore sought determine the mechanistic features diabetic dysfunction.
Identifying small molecules that are neuroprotective against stroke injury will be highly beneficial for treatment therapies. A cell viability assay and gas chromatography-mass spectrometry were used to identify active in XingNaoJing, which is a well known Chinese medicine prescribed the effective of stroke. Studies have found muscone compound prevents PC12 cortical neuron damage following various injuries. Analysis apoptosis indicated inhibited glutamate-induced apoptotic death cells...
As the major atheroprotective particle in plasma, high-density lipoprotein(HDL) is oxidized during atherosclerotic processes. Oxidized HDL(ox-HDL) may lose its cardioprotective properties and develop a proinflammatory proatherogenic phenotype. The proliferation migration of vascular smooth muscle cells(VSMCs) play crucial role atherogenesis. However, influence ox-HDL on VSMC remains poorly understood.VSMCs were treated with native HDL(N-HDL) or at varying concentrations for different time...
Molecules that enhance chondrogenic differentiation in mesenchymal stem cells (MSCs) were identified and isolated using an vitro Gli reporter gene assay MSCs incorporating a Sonic Hedgehog (Shh) target. Atractylenolide III, which promoted Gli1-mediated transcriptional activity, was from ethyl acetate extract of the Rhizoma, Atractylodis macrocephalae. After dehydration, atractylenolide III transformed to I. Both atractylenolides confirmed by MS, UV, IR, 1H- 13C-NMR spectra. (which contains...
Glycation of high-density lipoprotein (HDL) decreases its ability to induce cyclooxygenase-2 (COX-2) expression and prostacyclin I-2 (PGI-2) release in endothelial cells. Whether lipid content HDL, especially sphingosine-1-phosphate (S1P), plays any specific role restoring the protective function HDL type 2 diabetes mellitus (T2DM) is still unknown. Immunochemical techniques demonstrated that glycated loses regulating COX-2 compared with diabetic HDL. We proved content, phospholipid differed...
Endothelial dysfunction is involved in the pathophysiological processes of contrast media (CM)–induced acute kidney injury (CI-AKI) after vascular angiography or intervention. Previous study found that apolipoprotein A-I (apoA-I) mimetic peptide, D-4F, alleviates endothelial impairments via upregulating heme oxygenase-1 (HO-1) expression and scavenging excessively generated reactive oxygen species (ROS). However, whether D-4F could ameliorate oxidative injuries cells through suppressing ROS...
Abstract Obesity is a global issue that warrants the identification of more effective therapeutic targets and better understanding pivotal molecular pathogenesis. Annexin A1 (ANXA1) known to inhibit phospholipase A2, exhibiting anti-inflammatory activity. However, specific effects ANXA1 in obesity underlying mechanisms action remain unclear. Our study reveals levels are elevated adipose tissue individuals with obesity. Whole-body or adipocyte-specific deletion aggravates metabolic disorders....
In the context of digital economy, external connection executives provides enterprises with a good idea to amplify their potential for transformation help forces. Therefore, we conduct theoretical exploration and an empirical analysis relationship between executive connections enterprise transformation. As research sample, use A-share manufacturing companies listed in China from 2012 2021. According sufficient verifications, discover that can effectively support From perspective each...
Infectious coryza is an acute infectious respiratory disease in chickens that caused by Avibacterium paragallinarum (A. paragallinarum). has major economic effects due to decreased egg production growing birds and slowed growth broilers. In this study, we isolated identified 40 strains of A. from showed typical clinical signs part China 2019 2020. Using a hemagglutination-inhibition test, 11 isolates were as serovar A, 10 B, 19 C. Antimicrobial sensitivity tests high minimum inhibitory...