A5088732681- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Frailty in Older Adults
- Medical Imaging Techniques and Applications
- Infective Endocarditis Diagnosis and Management
- Neurological disorders and treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Advanced Fluorescence Microscopy Techniques
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac tumors and thrombi
- Conducting polymers and applications
- Diabetes Treatment and Management
- Advanced Biosensing Techniques and Applications
- Mechanical Circulatory Support Devices
- Pharmaceutical Practices and Patient Outcomes
- Cardiovascular Conditions and Treatments
Semmelweis University
2019-2024
München Klinik
2011
Abstract Aims Recommendations on cardiac resynchronization therapy (CRT) in patients with atrial fibrillation or flutter (AF) are based less robust evidence than those sinus rhythm (SR). We aimed to assess the efficacy of CRT upgrade BUDAPEST-CRT Upgrade trial population by their baseline rhythm. Methods and results Heart failure reduced ejection fraction (HFrEF) previously implanted pacemaker (PM) implantable cardioverter defibrillator (ICD) ≥20% right ventricular (RV) pacing burden were...
Background: The relative importance of variables explaining sex-related differences in outcomes is scarcely explored patients undergoing cardiac resynchronization therapy (CRT). We sought to implement and evaluate machine learning (ML) algorithms for the prediction 1- 3-year all-cause mortality CRT patients. also aimed assess sex-specific predictors utilizing ML. Methods: Using a retrospective registry 2,191 patients, ML models were implemented 6 partially overlapping patient subsets (all...
Preferring side branch of coronary sinus during cardiac resynchronization therapy (CRT) implantation has been empirical due to the limited data on association left ventricular (LV) lead position and long-term clinical outcome. We evaluated all-cause mortality by LV non-apical positions further characterized them interlead electrical delay (IED).In our retrospective database, 2087 patients who underwent CRT were registered between 2000 2018. Those with locations classified into anterior (n =...
Data on the relevance of anemia in heart failure (HF) patients with an ejection fraction (EF) > 40% by subgroup—preserved (HFpEF), mildly reduced (HFmrEF) and newly defined recovered EF (HFrecEF)—are scarce. Patients HF symptoms, elevated NT-proBNP, ≥ structural abnormalities were registered HFpEF-HFmrEF database. We described outcome our cohort presence anemia. Additionally, HFrecEF also selected from HFrEF who underwent resynchronization and, as responders, reached EF. Using propensity...
Abstract Heart failure (HF) is a leading cause of mortality and hospitalization in the elderly. However, data are scarce about their response to device treatment such as cardiac resynchronization therapy (CRT). We aimed evaluate age-related differences effectiveness CRT, procedure-related complications, long-term outcome. Between 2000 2020, 2656 patients undergoing CRT implantation were registered analyzed retrospectively. Patients divided into 3 groups according age: group I, < 65; II,...
Abstract Aims Patients with a pacemaker or implantable cardioverter-defibrillator are often considered for cardiac resynchronization therapy (CRT). However, limited comprehensive data available regarding their long-term outcomes. Methods and results Our retrospective registry included 2524 patients [1977 (78%) de novo, 547 (22%) upgrade patients] mild to severe symptoms, left ventricular ejection fraction ≤35%, QRS ≥ 130ms. The primary outcome was the composite of all-cause mortality, heart...
Aims Primary prevention of sudden cardiac death (SCD) in non-ischemic heart failure (HF) patients remains a topic debate at resynchronization therapy (CRT) implantation requiring individual risk assessment. Using the Goldenberg SCD score, we aimed to predict, which HF will benefit from addition an implantable cardioverter defibrillator (ICD) CRT long-term. Methods Between 2000 and 2018 undergoing were collected into our retrospective registry. The score (GRS) was calculated by presence...
Patients with obesity have an overall higher cardiovascular risk, at the same time could be associated a better outcome in certain subgroup of patients, phenomenon known as paradox. Data are scarce candidates for cardiac resynchronization therapy (CRT). We aimed to investigate association between body mass index (BMI) and all-cause mortality patients eligible CRT.
Abstract Background Pericardial tamponade is a serious condition which may eventually lead to severe haemodynamic disturbances and cardiac arrest. It most often caused by the accumulation of fluid inside pericardium, as result different aetiological factors such pericarditis, neoplastic diseases, lymphatic dysfunctions, or idiopathic pericardial disease. can develop after surgical procedures complication myocardial infarction. Collection blood sack be trauma. exceedingly rare for injury...
Current guidelines recommend considering multiple factors while deciding between cardiac resynchronization therapy with a defibrillator (CRT-D) or pacemaker (CRT-P). Nevertheless, it is still challenging to pinpoint those candidates who will benefit from choosing CRT-D device in terms of survival.
Abstract Choosing the optimal device during cardiac resynchronization therapy (CRT) upgrade can be challenging. Therefore, we sought to provide a solution for identifying patients in whom upgrading CRT-defibrillator (CRT-D) is associated with better long-term survival than CRT-pacemaker (CRT-P). To this end, first applied topological data analysis create patient similarity network using 16 clinical features of 326 without prior ventricular arrhythmias who underwent CRT upgrade. Then,...
Abstract Frailty is a complex clinical syndrome associated with aging and comorbidities, which correlates unfavorable outcomes. However, in heart failure patients, frailty very common, data scarce about those, who are eligible for Cardiac Resynchronization Therapy (CRT) implantation. We investigated the incidence of association Index (FI) outcome. Thirty baseline parameters were used by Rockwood cumulative deficit method to determine patients' FI our single-center cohort. Based on previous...
Abstract Introduction Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in selected patients with symptomatic heart failure reduced ejection fraction (HFrEF) prolonged QRS. However, approximately one-third of the implanted fail to show clinical improvement or reverse remodeling. The criteria by response have been recently changed, those a minimal left ventricular (LVEF) are defined as "non-progressors" rather than "non-responders", selecting from whom progression could...
Abstract Background Based on the results of BUDAPEST-CRT Upgrade trial, in patients with intermittent or permanent right ventricular (RV) pacing and reduced left ejection fraction (HFrEF) upgrade to cardiac resynchronization therapy (CRT) reduces morbidity mortality. Purpose Whether substantial treatment effect CRT could also be detected a better functional exercise capacity is scarcely investigated. We examined changes prespecified tertiary endpoints such as symptoms, quality life (QoL),...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main source(s): European Union. Background Overweight and obese people have a higher risk acquiring heart failure, however these patients tend to more favorable outcome, phenomenon known as the obesity paradox. Purpose We aimed investigate association body mass index (BMI) on all-cause mortality in failure CRT at long-term. Methods examined retrospectively 1585 undergoing implantation our clinic between...
Abstract Introduction Approximately one-third of patients undergoing cardiac resynchronization therapy (CRT) implantation fail to show echocardiographic improvement and are categorized as non-responders, despite probable beneficial clinical response. Purpose We aimed evaluate the long-term outcome CRT by their response outsorting those with unchanged parameters. Methods Altogether 1019 between 2000-2020 in our center were analyzed retrospectively. Patients grouped defined LVEF change upto12...
Abstract Background Utilizing remote monitoring (RM) in patients with heart failure (HF) who have cardiac implantable electronic devices (CIED) proves to be a dependable method for closely adhering device-specific and failure-related parameters. While there is some favorable outcome data, the results remain incomplete. Aims We aimed evaluate advantages of continuous RM compared standard care (SoC) reducing all-cause mortality, cardiovascular-related death (CV), sudden death, ICD shocks....
Abstract Introduction Left ventricular (LV) lead position is strongly associated with the long-term outcome of patients undergoing de novo cardiac resynchronization therapy (CRT) implantation. However, data scarce about who undergo upgrade CRT from right (RV) pacing. Aims To investigate impact LV location on primary heart failure (HF) hospitalization, all-cause mortality, or echocardiographic reverse remodelling in BUDAPEST Upgrade trial cohort. Methods Heart reduced ejection fraction...
We lack data on the effect of single premature ventricular contractions (PVCs) clinical and echocardiographic response after cardiac resynchronization therapy (CRT) device implantation. aimed to assess predictive value PVCs at early, 1 month-follow up all-cause mortality.In our prospective, single-center study, 125 heart failure patients underwent CRT implantation based current guidelines. Echocardiographic reverse remodeling was defined as a ≥ 15% improvement in left ejection fraction...
Háttér: A szívelégtelenségben szenvedő betegek egy igen fragilis betegcsoport, akik nagy kardiovaszkuláris (KV) mortalitási rizikóval rendelkeznek. Gyógyszeres kezelésükben paradigmaváltást hozott a nátrium-glükóz-kotranszporter-2 (SGLT2) gátlók alkalmazása, mivel csökkenteni tudta és szívelégtelenség események rizikóját. Módszerek: Jelen szakirodalmi összefoglalónkban azokat az SGLT2-gátlókkal végzett nagy, multicentrikus, randomizált vizsgálatokat (RCT) metaanalíziseket gyűjtöttük össze,...
Abstract Background The relative importance of variables explaining sex differences in outcomes is scarcely explored patients undergoing cardiac resynchronization therapy (CRT). Purpose We sought to implement and evaluate machine learning (ML) algorithms for the prediction 1- 3-year all-cause mortality CRT implantation. also aimed assess sex-specific similarities predictors using ML approaches. Methods A retrospective registry 2191 (75% males) was used current analysis. models were...
A kardiovaszkuláris megbetegedéseken belül a krónikus szívelégtelenség az egyik vezető oka időskori morbiditásnak, mortalitásnak és hospitalizációnak. Számos randomizált, kontrollált vizsgálat (RCT) igazolta, hogy kardiális reszinkronizációs terápia (CRT) hatékonyan csökkenti morbiditást mortalitást megfelelően szelektált betegekben. Azonban legtöbb RCT-ben idős populáció alulreprezentált volt, ezért idősekben kialakult, CRT-re adott válaszkészség leírására ezen vizsgálatok kevésbé...
Due to its heterogeneous clinical picture and lengthy evolution, the management of type B aortic dissection represents a challenge, often calling for complex strategies combining medical, endovascular, open surgical strategies. We present case 45-year-old female who had previously suffered complicated requiring femoro-femoral crossover bypass further conservative treatment. Seven years later, due an aneurysmal development, staged descending was strategized, beginning with implantation frozen...