A5017735856- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Diversity and Career in Medicine
- Bone Tissue Engineering Materials
- Advances in Oncology and Radiotherapy
- COVID-19 and healthcare impacts
- Cleft Lip and Palate Research
- Wound Healing and Treatments
- Craniofacial Disorders and Treatments
- Pluripotent Stem Cells Research
- Biomedical Ethics and Regulation
- Surgical Simulation and Training
- Nutrition and Health in Aging
- Mast cells and histamine
- Laser Applications in Dentistry and Medicine
- Autophagy in Disease and Therapy
- LGBTQ Health, Identity, and Policy
- Cardiac, Anesthesia and Surgical Outcomes
- Medical Education and Admissions
- Cancer, Hypoxia, and Metabolism
- Breast Cancer Treatment Studies
- Sexuality, Behavior, and Technology
- COVID-19 diagnosis using AI
- dental development and anomalies
- Congenital Anomalies and Fetal Surgery
University of California Davis Medical Center
2023
University of North Carolina at Chapel Hill
2020-2021
University of North Carolina Health Care
2020
University of California, Davis
2017
Stanford University
2011-2013
University of California, San Francisco
2012-2013
California Institute for Regenerative Medicine
2012
San Francisco General Hospital
2011
Pluripotent cells represent a powerful tool for tissue regeneration, but their clinical utility is limited by propensity to form teratomas. Little known about interaction with the surrounding niche following implantation and how this may be applied promote survival functional engraftment. In study, we evaluated ability of an osteogenic microniche consisting hydroxyapatite-coated, bone morphogenetic protein-2–releasing poly- l -lactic acid scaffold placed within context macroenvironmental...
Angiogenesis is essential to wound repair, and vascular endothelial growth factor (VEGF) a potent stimulate angiogenesis. Here, we examine the potential of VEGF-overexpressing adipose-derived stromal cells (ASCs) for accelerating healing using nonviral, biodegradable polymeric vectors. Mouse ASCs were transfected with DNA plasmid encoding VEGF or green fluorescent protein (GFP) poly (β-amino) esters (PBAE). Cells Lipofectamine 2000, commercially available transfection reagent, included as...
Abstract Background Although mechanical osteotomies are frequently made on the craniofacial skeleton, collateral thermal, and trauma to adjacent bone tissue causes cell death may delay healing. The present study evaluated use of plasma‐mediated laser ablation using a femtosecond circumvent thermal damage improve regeneration. Methods Critical‐size circular calvarial defects were created with trephine drill bit or Ti:Sapphire pulsed laser. Healing was followed micro‐CT scans for 8 weeks....
Wound healing is a complex biological process involving the interaction of many cell types to replace lost or damaged tissue. Although biology wound has been extensively investigated, few studies have focused on role mast cells. In this study, we investigated possible cells in by analyzing aspects cutaneous excisional three genetically cell-deficient mice. We found that C57BL/6-KitW-sh/W-sh, WBB6F1-KitW/W-v, and Cpa3-Cre; Mcl-1fl/fl mice re-epithelialized splinted skin wounds at rates very...
Tissue regeneration using progenitor cell-based therapy has the potential to aid in healing of a diverse range pathologies, ranging from short-gut syndrome spinal cord lesions. However, there are numerous hurdles be overcome prior widespread application these cells clinical setting. One primary barriers effective stem cell is hostile environment that encounter injury wound In order promote cellular survival, differentiation, and participation tissue regeneration, relevant delivery scaffolds...
Retroperitoneal sarcomas (RPS) are rare tumors for which surgical resection is the principal treatment. There no established model to predict perioperative risks RPS. We evaluated association between preoperative sarcopenia, frailty, and hypoalbuminemia with oncological outcomes.We performed a prospective cohort analysis of 65 RPS patients who underwent resection. Sarcopenia was defined as Total Psoas Area Index ≤ 1st quintile by sex. Frailty estimated using modified frailty index (mFI)....
Craniofacial skeletal repair and regeneration offers the promise of de novo tissue formation through a cell-based approach utilizing stem cells. Adipose-derived stromal cells (ASCs) have proven to be an abundant source multipotent capable undergoing osteogenic, chondrogenic, adipogenic, myogenic differentiation. Many studies explored osteogenic potential these in vivo with use various scaffolding biomaterials for cellular delivery. It has been demonstrated that by osteoconductive,...
Abstract Background The purpose of this study was to characterize the orthopedic trauma workload in Bedford Orthopaedic Centre (BOC), an referral hospital rural South Africa. Methods Demographic data, injury and information about initial management were collected for two 6‐week periods during both 2008 2009 from patients seen BOC outpatient department. Two primary outcomes evaluated: (1) interval between outside evaluation consultation (2) presence established infection at time consultation....
Craniofacial skeletal repair and regeneration offers the promise of de novo tissue formation through a cell-based approach utilizing stem cells. Adipose-derived stromal cells (ASCs) have proven to be an abundant source multipotent capable undergoing osteogenic, chondrogenic, adipogenic, myogenic differentiation. Many studies explored osteogenic potential these in vivo with use various scaffolding biomaterials for cellular delivery. It has been demonstrated that by osteoconductive,...