A5012639631- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Lung Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Tracheal and airway disorders
- Multiple and Secondary Primary Cancers
- Cancer-related gene regulation
- Heavy Metal Exposure and Toxicity
- Epigenetics and DNA Methylation
- Congenital Diaphragmatic Hernia Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Digestive system and related health
- Dysphagia Assessment and Management
- Statistical Methods in Clinical Trials
- Stoma care and complications
- Lymphatic System and Diseases
- Sexual function and dysfunction studies
- Vascular Tumors and Angiosarcomas
- Acute Kidney Injury Research
- Cancer, Lipids, and Metabolism
The Japanese Society of Gastroenterological Surgery
2025
Osaka Ekisaikai Hospital
2023-2025
NTT Medical Center
2025
Koshigaya Municipal Hospital
2021-2024
Nagoya City University
2021-2023
Juntendo University
2010-2022
Nagoya City University Hospital
2020
Creative Research Enterprises (United States)
2016
Juntendo University Shizuoka Hospital
1999-2016
Juntendo University Hospital
2013-2014
Gastric adenocarcinoma of fundic-gland type (GA-FG) is a rare variant gastric neoplasia. However, the etiology, classification, and clinicopathological features epithelial neoplasm mucosa lineage (GEN-FGML; generic term GA-FG related neoplasm) are not fully elucidated. We performed large, multicenter, retrospective study to establish new classification clarify GEN-FGML.
Several studies have evaluated associations between the characteristics of patients with esophageal and gastric cancer survival, but these remain unclear. We described distribution demographic lifestyle factors among in Japan, investigated their potential effects on survival. Between 2003 2007, 24- to 95-year-old Japanese were enrolled BioBank Japan Project. The analysis included 365 squamous cell carcinoma (ESCC) 1574 cancer. Hazard ratios (HRs) 95% confidence intervals (CIs) for mortality...
AIMTo investigate clinicopathological features of early stage gastric cancer with enteroblastic differentiation (GCED). METHODSWe retrospectively investigated data on 6 cases GCED and 186 conventional (CGC: well or moderately differentiated a d e n o c r i m ) w h u t s p submucosal dissection endoscopic mucosal resection from September 2011 to February 2015 in our hospital.
In squamous cell carcinoma (SCC) of the esophagus, D2‐40 immunostaining has recently been used to detect lymphatic invasion, but invasion detected using for a predictor nodal metastasis was controversial. Therefore, usefulness detecting by as examined in superficial (mucosal and submucosal) SCC esophagus. A total 115 esophagus were on immunohistochemistry D2‐40. It found that demonstrated mainly lamina propria mucosa. Lymphatic 37 cases entire tumor tissue statistically correlated with...
<b><i>Aims:</i></b> We aimed to clarify the endoscopic/clinicopathological features of superficial non-ampullary duodenal epithelial tumors (SNADETs) based on their mucin phenotypes. <b><i>Methods:</i></b> analyzed 62 SNADET lesions and classified them phenotypic expression. Endoscopic clinicopathological findings were compared according <b><i>Results:</i></b> Eleven had gastric phenotype (GP) 43 intestinal (IP). All GP...
To determine the efficacy of postoperative adjuvant chemotherapy with docetaxel + cisplatin 5-fluorouracil (DCF) in lymph node metastasis-positive esophageal cancer, we retrospectively analyzed 139 patients stage II/III (non‑T4) cancer metastasis (1-6 nodes), who did not receive preoperative treatment and underwent three‑field dissection Juntendo University Hospital between December, 2004 2009. tumors were histologically diagnossed as squamous cell carcinoma. The divided into two groups, a...
Phosphodiesterase 5 inhibitors are widely used to treat erectile dysfunction and lower urinary tract symptoms with benign prostatic hyperplasia. Recent studies have indicated the renoprotective effects of this class compounds. Whether renoprotection depends on blood pressure reduction remains controversial. In study, we investigated phosphodiesterase inhibitor, tadalafil, in a rat model high-salt induced kidney injury hypertension. Dahl salt-sensitive rats were fed normal diet, (8% sodium...
Esophageal squamous cell cancer (ESCC) is a high-grade carcinoma that treated with multidisciplinary approaches, including chemoradiotherapy (CRT) followed by surgery. Despite some success these therapies, overall survival remains poor. In order to investigate newer CRT regimen, we designed comparative study evaluate preoperative using docetaxel (DOC) or 5-Fluorouracil and cisplatin (FU+CDDP [FP] therapy) for treatment of resectable ESCC. retrospective review patients resectable, locally...
The usefulness of 0.6% sodium alginate (SA) as a submucosal (SM) injection solution for endoscopic SM dissection (ESD) has gained attention over the past few years. However, using ESD colorectal neoplastic lesions is not explicitly researched yet. Thus, we conducted this study to determine feasibility and safety SA ESD.In single-center, retrospective pilot study, total 100 cases treated with neoplasia at our institute were retrospectively reviewed clarify clinical SA. primary endpoint was...
悪性度の高い食道癌に対してリンパ節郭清の徹底化を図るためにわが国で3領域リンパ節郭清手術が完成された. 他の消化器癌手術に比べ難易度や侵襲度の高い本手術の適応と限界を生存解析から明らかにすることが本研究の目的である. 食道癌に対する3領域リンパ節郭清手術後の生存解析の結果からその治療成績は必ずしも均霑化されておらず施設間格差が存在すると考えられる. また3領域リンパ節郭清手術の郭清効果が十分に期待できるのは転移個数が5個以下の症例であり, 厳格な3領域リンパ節郭清手術を施行することによって局所進行食道癌に対して60%前後の5年生存率が期待でき, この生存率は根治CRTの成績よりも良好であった. 一方リンパ節転移個数は食道癌の最も強力な予後因子であり, 転移個数が6個以上に予後は急激に低下するためリンパ節多数転移例に対しては今後新たな全身治療法の開発が必須であると考えられる.
Objective: We evaluated various cytokines in patients with esophageal cancers to elucidate the relationship between Th1/Th2 balance and patients’ prognosis. Materials Methods: Various serum of preoperative 98 patients, who subsequently underwent radical esophagectomy September 2005 December 2006, were quantitatively measured by Cytometric Bead Array (CBA) system. The include related 14 cytokines-IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12p70, IL-13, IL-17A, INFγ IgE....
目的: 食道癌は適切な根治手術が行われてもなお再発が多く予後不良な疾患である. Stageの早い症例でも術後再発をきたす場合があり, このような症例では従来の組織学的手法では検出されない微小転移巣の関与が推測される. 本研究では, 手術で郭清されたリンパ節に対して抗サイトケラチン抗体 (CK13) 染色による免疫組織化学的染色法を用いて, 食道癌のリンパ節微小転移を検索しその臨床的意義について考察した. 対象: 2000年に順天堂医院食道・胃外科で切除された食道癌症例80例のうち組織型が分化型扁平上皮癌で術前治療を行わず, 系統的3領域郭清が行われ, かつ予後の追跡が可能であった28症例とした. 方法: 手術で郭清されたリンパ節3289個を病理組織検索の後3μmに薄切しCK13を用いて染色, 鏡検し予後因子の解析を行った. 結果: 全3289個のリンパ節のうちHE染色では20症例102個のリンパ節に転移を認めた. CK13染色による検索で新たに11症例19個の微小転移が認められた. この11症例はHE染色で転移なし (pO)...