A5101494096- RNA modifications and cancer
- RNA Research and Splicing
- Advanced Breast Cancer Therapies
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- Genetic factors in colorectal cancer
- HER2/EGFR in Cancer Research
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Cholesterol and Lipid Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer-related Molecular Pathways
- Extracellular vesicles in disease
- RNA and protein synthesis mechanisms
- Peripheral Artery Disease Management
- Lipid metabolism and biosynthesis
- Angiogenesis and VEGF in Cancer
- Childhood Cancer Survivors' Quality of Life
- Gestational Trophoblastic Disease Studies
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Hematological disorders and diagnostics
Dalian Medical University
2017-2025
Second Affiliated Hospital of Dalian Medical University
2017-2025
Chengdu Medical College
2023
Zhejiang University
2009
Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression, yet how this process is regulated by oncogenic signal remains largely unknown. Here, we unveil that non-canonical activation nuclear AURKA promotes an suppressor RBM4 directed m6A reader YTHDC1 in lung cancer. Nuclear translocation a prerequisite for aberrant splicing, specifically triggering from the full isoform (RBM4-FL) short (RBM4-S) kinase-independent manner. RBM4-S functions as promoter...
Psychological stress causes gut microbial dysbiosis and cancer progression, yet how microbiota determines psychological stress-induced tumor development remains unclear. Here we showed that promotes breast growth stemness, an outcome depends on in germ-free antibiotic-treated mice. Metagenomic metabolomic analyses revealed markedly alters the composition abundance of microbiota, especially Akkermansia muciniphila (A. muciniphila), decreases short-chain fatty acid butyrate. Supplement active...
Abstract Transcription cofactor Yes-associated protein (YAP) plays an important role in cancer progression. Here, we found that Aurora A kinase expression was positively correlated with YAP lung cancer. depletion suppresses cell colony formation, which could be reversed by ectopic overexpression. In addition, activation of increases abundance through maintaining its stability. Consistently, the transcriptional activity is increased upon activation. We further showed shAURKA suppressed...
// Tao Guo 1, 2, * , Shilei Zhao Peng Wang Xiaoyuan Xue 3 Yan Zhang 4 Mengying Yang Nan Li Zhuoshi 2 Lingzhi Xu 5 Lei Jiang 6 Patrick C. Ma 7 Rafael Rosell 8 Jinxiu and Chundong Gu 1 Department of Thoracic Surgery, The First Affiliated Hospital Dalian Medical University, 116011, China Lung Cancer Diagnosis Treatment Center Dalian, Institute Stem Cell, 116044, Radiation Oncology, Qianfoshan to Shandong Jinan 250000, Second Hospital, Fourth Anhui Hefei 230000, Aerodigestive Oncology...
The mediator complex usually cooperates with transcription factors to be involved in RNA polymerase II-mediated gene transcription. As one component of this complex, MED27 has been reported our previous studies promote thyroid cancer and melanoma progression. However, the precise function breast development remains poorly understood. Here, we found that was more highly expressed samples than normal tissues, especially triple-negative cancer, its expression level elevated increase...
Pancreatic cancer is a malignant tumor of the digestive tract, rendering it difficult to make an accurate diagnosis. The 5 year survival rate for pancreatic <1%, and surgical resection rarely proves be effective. Therefore, identification more effective methods early detection urgent requirement. present study aimed explore key genes microRNAs (miRNAs) associated with pathogenesis cancer. Public databases were searched, data integrated from Cancer Genome Atlas Gene Expression Omnibus...
The contribution of oncogenes to tumor-associated RNA splicing and the relevant molecular mechanisms therein require further elaboration. Here, we show that oncogenic Aurora kinase A (AURKA) promotes breast cancer-related aberrant in a context-dependent manner. AURKA regulated pan-breast cancer-associated events including GOLGA4, RBM4 UBQLN1. Aberrant GOLGA4 was closely related cancer development. Mechanistically, interacted with factor YBX1 promoted AURKA-YBX1 complex-mediated exon...
Diabetic nephropathy is a major complication facing patients with diabetes mellitus. The renal protective effects of the phosphodiesterase III inhibitor, cilostazol, were investigated in rats streptozotocin-induced diabetes. Expression thrombospondin-1 (TSP-1) and transforming growth factor-β (TGF-β) kidney was measured by immunohistochemistry real-time reverse transcription-quantitative polymerase chain reaction analysis diabetic rats, cilostazol-treated control rats. Ultrastructural...
Abstract Drug resistance is the leading cause for rapid progression and relapse in small‐cell lung cancer (SCLC) patients. Thus overcoming drug still remains to be urgently resolved during SCLC treatment. Here, we found p62/SQSTM1 was enriched spheroids, a subpopulation possessing stem‐like properties, which responsible metastasis. Subsequent functional assays vitro showed that short hairpin RNA (shRNA)‐mediated p62 knockdown increased sensitivity of cell lines cisplatin (DDP), whereas...
Approximately 30% of breast cancer (BC) patients suffer from disease relapse after definitive treatment. Monitoring BC at baseline and progression using comprehensive genomic profiling would facilitate the prediction prognosis. We retrospectively studied 101 ultimately experiencing and/or metastases. The circulating tumor DNA‐monitoring cohorts included with tissue serial plasma samples, respectively. Samples were analyzed targeted next‐generation sequencing 425 cancer‐relevant genes. Of 35...
Abstract Background: Exosomes play important roles in intercellular communication by delivering microRNAs (miRNAs) that mediate tumor initiation and development, including those diffuse large B cell lymphoma (DLBCL). To date, however, limited studies on the inhibitory effect of exosomes derived from human bone marrow-derived mesenchymal stem cells (hBMSCs) DLBCL progression have been reported. Therefore, this study aimed to investigate role hBMSC-secreted carrying microRNA-124-3p development...
e13048 Background: Randomized controlled trials (RCTs) found that PAL plus ET had a considerable survival advantage in patients with HR+/HER2- ABC compared to ET. This real-world study aimed complement the existing RCTs addition accounting for patient characteristics, adherence treatment, and socioeconomic factors. Methods: Data of who HR+HER2- received (N=216) (N=215) from September 2007 May 2020 were retrospectively retrieved electronic medical record system seven cancer centers across...
Abstract Purpose: Pyrotinib, a novel human epidermal growth factor receptor 2 (HER2)-targeted tyrosine kinase inhibitor (TKI), was approved for second-line standards of treatment HER2-positive advanced breast cancer (ABC) in China. This real-world study aimed to assess the actual efficacy and safety pyrotinib HER2+ ABC. Methods: In this multicenter, retrospective, observational study, we analyzed 171 patients with ABC, who received pyrotinib-based from November 2017 2020. The primary end...
e13039 Background: Palbociclib has been approved as the first CDK4/6 inhibitor in China since 2018. This study aimed to collect real-world data for retrospective analysis of clinical outcomes and potential genetic risk factors plus ET. Methods: Data 194 HR+HER2- ABC patients who received ET between May 2018 Dec 2020 were collected from electronic medical record system seven cancer centers across China. Cox regression models bioinformatic conducted investigate factors. Results: In total,...
Abstract Introduction: Choriocarcinoma is a highly invasive gestational trophoblastic tumor,which quite rare. In this case report, we analyzed the CT image features in of primary choriocarcinoma anterior mediastinum accompanying with lung metastasis. Patient concerns: A 24-year-old male patient had recurrent chest pain for over 20 days, fever, expectoration blood-stained sputum 10 days. Diagnosis: revealed huge mass and several quasi-circular nodules bilateral lungs.The pathological...