A5040686319- Venomous Animal Envenomation and Studies
- Turtle Biology and Conservation
- Hormonal and reproductive studies
- Insect and Pesticide Research
- Rabies epidemiology and control
- Physiological and biochemical adaptations
- Amphibian and Reptile Biology
- Neurobiology and Insect Physiology Research
- Bat Biology and Ecology Studies
- Marine Invertebrate Physiology and Ecology
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Antimicrobial Peptides and Activities
- Beetle Biology and Toxicology Studies
- Reproductive biology and impacts on aquatic species
- Wildlife Ecology and Conservation
- Pharmacological Effects and Assays
- Mercury impact and mitigation studies
- Biomedical Text Mining and Ontologies
- Cell Adhesion Molecules Research
- Animal Behavior and Reproduction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Insect and Arachnid Ecology and Behavior
- Silk-based biomaterials and applications
- Insect Resistance and Genetics
Madrid Institute for Advanced Studies
2017-2024
QIMR Berghofer Medical Research Institute
2016-2024
The University of Queensland
2014-2024
Universidad Autónoma de Madrid
2017-2021
IMDEA Food
2020-2021
National Institute of Advanced Industrial Science and Technology
2020
Institute of Bioorganic Chemistry
2020
University of Toyama
2020
KU Leuven
2020
University of Tasmania
2004-2006
Abstract Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence aging and offer therapeutic interventions. Here we report identification Cardiac Glycosides (CGs) as a family compounds senolytic activity. CGs, by targeting Na+/K+ATPase pump, cause disbalanced electrochemical gradient within cell causing depolarization acidification. Senescent cells present slightly depolarized plasma membrane higher concentrations H+, making...
Abstract Venoms have evolved >100 times in all major animal groups, and their components, known as toxins, been fine-tuned over millions of years into highly effective biochemical weapons. There are many outstanding questions on the evolution toxin arsenals, such how venom genes originate, contributes to fitness venomous species, which modifications at genomic, transcriptomic, protein level drive evolution. These received particularly little attention outside snakes, cone snails,...
The cytotoxicity of the venom 25 species Old World elapid snake was tested and compared with morphological behavioural adaptations hooding spitting. We determined that, contrary to previous assumptions, venoms spitting are not consistently more cytotoxic than those closely related non-spitting species. While this correlation between found among African cobras, it present Asian cobras. On other hand, a consistent positive observed utilisation defensive display that cobras famous for. Hooding...
Caveolae and caveolin-1 (CAV1) have been linked to several cellular functions. However, a model explaining their roles in mammalian tissues vivo is lacking. Unbiased expression profiling cell types identified lipid metabolism as the main target affected by CAV1 deficiency. CAV1−/− mice exhibited impaired hepatic peroxisome proliferator-activated receptor α (PPARα)-dependent oxidative fatty acid ketogenesis. Similar results were recapitulated CAV1-deficient AML12 hepatocytes, suggesting at...
Consistent with their diverse pharmacology, peptides derived from venomous animals have been developed as drugs to treat disorders hypertension, diabetes and chronic pain. Melanoma has a poor prognosis due in part its metastatic capacity, warranting further development of novel targeted therapies. This prompted us examine the anti-melanoma activity spider gomesin (AgGom) gomesin-like homolog (HiGom). AgGom HiGom dose-dependently reduced viability proliferation melanoma cells whereas it had...
Serum ferritin concentrations increase during hepatic inflammation and correlate with the severity of chronic liver disease. Here, we report a molecular mechanism whereby heavy subunit (FTH) contributes to inflammation. We found that FTH induced activation NLRP3 inflammasome secretion proinflammatory cytokine interleukin-1β (IL-1β) in primary rat stellate cells (HSCs) through intercellular adhesion molecule–1 (ICAM-1). FTH–ICAM-1 stimulated expression Il1b , activation, processing IL-1β...
Abstract The inexorable decline in the armament of registered chemical insecticides has stimulated research into environmentally-friendly alternatives. Insecticidal spider-venom peptides are promising candidates for bioinsecticide development but it is challenging to find that specific targeted pests. In present study, we isolated an insecticidal peptide (Ae1a) from venom African spider Augacephalus ezendami (family Theraphosidae). Injection Ae1a sheep blowflies ( Lucilia cuprina ) induced...
Aculeate hymenopterans use their venom for a variety of different purposes. The solitary aculeates paralyze and preserve prey without killing it, whereas social utilize in defence colony. These distinct applications suggest that its components functions are also likely to differ. This study investigates range species across Aculeata. We combined electrophoretic, mass spectrometric, transcriptomic techniques characterize the compositions venoms from an incredibly diverse taxon. In addition,...
Abstract Research on animal venoms and their components spans multiple disciplines, including biology, biochemistry, bioinformatics, pharmacology, medicine, more. Manipulating analyzing the diverse array of data required for venom research can be challenging, relevant tools resources are often dispersed across different online platforms, making them less accessible to nonexperts. In this article, we address multifaceted needs scientific community involved in toxin-related by identifying...
The Tasmanian devil faces extinction due to facial tumour disease (DFTD), a highly transmittable clonal form of cancer without available treatment. In this study, we report the cell-autonomous antiproliferative and cytotoxic activities exhibited by spider peptide gomesin (AgGom) gomesin-like homologue (HiGom) in DFTD cells. Mechanistically, both peptides caused significant reduction at G0/G1 phase, correlation with an augmented expression cell cycle inhibitory proteins p53, p27, p21,...
Snakes of the genera Pseudocerastes and Eristicophis (Viperidae: Viperinae) are known as desert vipers due to their association with arid environments Middle East. These species have received limited research attention little is about venom or ecology. In this study, a comprehensive analysis viper venoms was conducted by visualising proteomes via gel electrophoresis assessing crude for cytotoxic, haemotoxic, neurotoxic properties. Plasmas sourced from human, toad, chicken were used models...
Venoms are a rich source of potential lead compounds for drug discovery, and descriptive studies venom form the first phase biodiscovery process. In this study, we investigated pharmacological crude Pseudocerastes Eristicophis snake venoms in haematological disorders cancer treatment. We assessed their antithrombotic using fibrinogen thromboelastography, gels with without protease inhibitors, colourimetric fibrinolysis assays. These assays indicated that anticoagulant properties likely...
Herbivorous turtle, Chelonia mydas , inhabiting the south China Sea and breeding in Peninsular Malaysia, Natator depressus a carnivorous turtle Great Barrier Reef at Curtis Island Queensland, Australia, differ both diet life history. Analysis of plasma metabolites levels six sex steroid hormones during peak their nesting season species showed hormonal metabolite variations. When compared with results from other studies progesterone were highest whereas dihydrotestosterone was hormone present...
Many chemical insecticides are becoming less efficacious due to rising resistance in pest species, which has created much interest the development of new, eco-friendly bioinsecticides. Since insects primary prey most spiders, their venoms a rich source insect-active peptides that can be used as leads for new bioinsecticides or tools study molecular receptors insecticidal targets. In present study, we isolated two peptides, µ/ω-TRTX-Mb1a and -Mb1b, from venom African tarantula Monocentropus...