A5012902352- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Microbial infections and disease research
- Reproductive Physiology in Livestock
- Cancer-related molecular mechanisms research
- Animal Disease Management and Epidemiology
- Mycobacterium research and diagnosis
- Animal Genetics and Reproduction
- Ginseng Biological Effects and Applications
- Vector-Borne Animal Diseases
- T-cell and Retrovirus Studies
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- Colorectal Cancer Treatments and Studies
- Chromosomal and Genetic Variations
- Genetic factors in colorectal cancer
- Respiratory viral infections research
- RNA Research and Splicing
- Reproductive System and Pregnancy
- Nutrition, Genetics, and Disease
- Plant Disease Resistance and Genetics
- Animal Behavior and Welfare Studies
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Reproductive Biology and Fertility
Washington State University
2016-2025
Montana State University
2020
Texas A&M University
1992-2017
West Texas A&M University
2017
University of Missouri
2017
Norton Healthcare
2002-2007
The University of Texas Medical Branch at Galveston
2007
Advanced ENT and Allergy
2007
University of Louisville
1996-2000
National Animal Disease Center
1994-1998
ABSTRACT Bovine respiratory disease (BRD) is a common health problem for both dairy and beef cattle, resulting in significant economic loses. In order to identify viruses associated with BRD, we used metagenomics approach enrich sequence viral nucleic acids the nasal swabs of 50 young cattle symptoms BRD. Following deep sequencing, de novo assembly, translated protein similarity searches, numerous known previously uncharacterized were identified. adenovirus 3, bovine adeno-associated virus,...
In 2008, a consortium led by the Agricultural Research Service (ARS) and National Institute for Food Agriculture (NIFA) published "Blueprint USDA Efforts in Animal Genomics 2008-2017," which served as guiding document research funding animal genomics. decade that followed, many of goals set forth blueprint were accomplished. However, several other require further research. addition, new topics not covered original blueprint, are result emerging technologies, exploration. To develop new,...
The Pecorans (higher ruminants) are believed to have rapidly speciated in the Mid-Eocene, resulting five distinct extant families: Antilocapridae, Giraffidae, Moschidae, Cervidae, and Bovidae. Due rapid radiation, Pecoran phylogeny has proven difficult resolve, 11 of 15 possible rooted phylogenies describing ancestral relationships among Bovidae each been argued as representations true phylogeny. Here we demonstrate that a genome-wide single nucleotide polymorphism (SNP) genotyping platform...
Single nucleotide polymorphism (SNP) arrays for domestic cattle have catalyzed the identification of genetic markers associated with complex traits inclusion in modern breeding and selection programs. Using actual imputed Illumina 778K genotypes 3887 U.S. beef from 3 populations (Angus, Hereford, SimAngus), we performed genome-wide association analyses feed efficiency growth including average daily gain (ADG), dry matter intake (DMI), mid-test metabolic weight (MMWT), residual (RFI),...
A major unresolved issue is how the uterus influences infertility and subfertility in cattle. Serial embryo transfer was previously used to classify heifers as high-fertile (HF), subfertile (SF), or infertile (IF). To assess pregnancy loss, two vivo-produced embryos were transferred into HF, SF, IF on day 7, outcome assessed 17. Pregnancy rate substantially higher HF (71%) SF (90%) than (20%) heifers. Elongating conceptuses about twofold longer Transcriptional profiling detected relatively...
Bovine respiratory disease complex (BRDC) is an infectious of cattle that caused by a combination viral and/or bacterial pathogens. Selection for with reduced susceptibility to would provide permanent tool reducing the prevalence BRDC. The objective this study was identify BRDC loci in pre-weaned Holstein calves as prerequisite using genetic improvement decreasing High density SNP genotyping Illumina BovineHD BeadChip conducted on 1257 male and 757 female from California (CA), 767 identified...
The purpose of this study was to identify loci associated with Mycobacterium avium subspecies paratuberculosis (Map) infection status in US Holsteins using the Illumina BovineSNP50 BeadChip whole genome single nucleotide polymorphism (SNP) assay. Two hundred forty-five cows from dairies New York, Pennsylvania and Vermont enrolled longitudinal herd studies between January 1999 November 2007 were assessed for presence Map both faecal tissue samples. An animal considered infected if any sample...
The identification of genetic markers associated with complex traits that are expensive to record such as feed intake or efficiency would allow these be included in selection programs. To identify large-effect QTL, we performed a series genome-wide association studies and functional analyses using 50 K 770 SNP genotypes scored 5,133 animals from 4 independent beef cattle populations (Cycle VII, Angus, Hereford Simmental × Angus) phenotypes for average daily gain, dry matter intake, metabolic...
Bovine respiratory disease complex (BRDC) is an important cause of mortality and morbidity in cattle; costing the dairy beef industries millions dollars annually, despite use vaccines antibiotics. BRDC caused by one or more several viruses (bovine syncytial virus, bovine herpes type 1 also known as infectious rhinotracheitis, viral diarrhea virus), which predispose animals to infection with bacteria. These include: Pasteurella multocida, Mannheimia haemolytica, Mycoplasma bovis, Histophilus...
Infertility and subfertility are important pervasive reproductive problems in both domestic animals humans. The majority of embryonic loss occurs during the first three weeks pregnancy cattle women due, part, to inadequate endometrial receptivity for support embryo implantation. To identify heifers contrasting fertility, serial rounds artificial insemination (AI) were conducted 201 synchronized crossbred beef heifers. then fertility classified based on number pregnancies detected day 35 four...
Susceptibility to bovine respiratory disease (BRD) is multi-factorial and influenced by stress in conjunction with infection both bacterial viral pathogens. While vaccination broadly used an effort prevent BRD, it far from being fully protective cases diagnosed a combination of observed clinical signs without any attempt at identifying the causal pathogens are usually treated antibiotics. Dairy beef cattle losses BRD profound worldwide genetic studies have now been initiated elucidate host...
Infertility and subfertility negatively impact the economics reproductive performance of cattle. Of note, significant pregnancy loss occurs in cattle during first month pregnancy, yet little is known about genetic loci influencing success To identify quantitative trait (QTL) with large effects associated early loss, Angus crossbred heifers were classified based on day 28 outcomes to serial embryo transfer. A genome wide association analysis (GWAA) was conducted comparing 30 high fertility...
Infertility and subfertility represent major problems in domestic animals humans, the majority of embryonic loss occurs during first month gestation that involves pregnancy recognition conceptus implantation. The critical genes physiological pathways endometrium mediate establishment success are not well understood. In study one, predominantly Angus heifers were classified based on fertility using serial embryo transfer to select with intrinsic differences loss. each four rounds, a single...
Human milk oligosaccharides (HMO), the third most abundant component of human milk, are thought to be important contributors infant health. Studies have provided evidence that geography, stage lactation, and Lewis secretor blood groups associated with HMO profile. However, little is known about how variation across genome may influence composition among women in various populations. In this study, we performed genome-wide association analyses 395 from 8 countries identify genetic regions 19...
Oligonucleotide primers for the polymerase chain reaction (PCR) that enable genus-specific detection of members genus Salmonella were developed. The amplify a 496-bp genetic sequence Salmonella. Amplification DNA extracted from all other genera family Enterobacteriaceae and various gram-positive aerobic anaerobic bacteria yielded negative results. Applications PCR using these are discussed.
Johne's disease, caused by Mycobacterium avium subspecies paratuberculosis (Map), is a fatal disease in cattle. The objective of this study was to identify loci associated with tolerance cows infected Map. Tolerance defined as cow's fitness at given level Map infection intensity. Fitness measured faecal cultures, and intensity culturing four gut tissues. quantitative phenotype numerical indexes cultures peak (peak tolerance, PT) average (average AT) tissue from 245 Holstein cows. categorical...
Background Like human immunodeficiency virus (HIV), ovine lentivirus (OvLV) is macrophage-tropic and causes lifelong infection. OvLV infects one quarter of U.S. sheep induces pneumonia body condition wasting. There no vaccine to prevent infection cost-effective treatment for infected animals. However, breed differences in prevalence proviral concentration have indicated a genetic basis susceptibility OvLV. A recent study identified TMEM154 variants susceptibility. The objective here was...
Heifer conception rate (HCR) is defined as the percentage of inseminated heifers that become pregnant at each service. The genome-wide association analyses in this study focused on identifying loci associated with Holstein heifer (n = 2013) first service (HCR1) and number times bred (TBRD) to achieve a pregnancy. There were 348 unique (p < 5 × 10−8) HCR1 615 TBRD. two phenotypes shared 302 loci, 56 validated independent cattle populations. 52 transcription factor binding sites (TFBS) 552...