A5037949315- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- Circular RNAs in diseases
- Advanced Proteomics Techniques and Applications
- dental development and anomalies
- RNA modifications and cancer
- Protein Structure and Dynamics
- Cancer, Hypoxia, and Metabolism
- Enzyme Structure and Function
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- Genetic Associations and Epidemiology
- Cellular Mechanics and Interactions
- Epigenetics and DNA Methylation
- Computational Drug Discovery Methods
- Orthodontics and Dentofacial Orthopedics
- Dental Radiography and Imaging
- Ginger and Zingiberaceae research
- Histone Deacetylase Inhibitors Research
- Glycosylation and Glycoproteins Research
- Spaceflight effects on biology
- Neonatal Respiratory Health Research
- Lipid metabolism and biosynthesis
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
National Center for Clinical Laboratories
2024-2025
Air Force Medical University
2022-2025
Université de Montréal
2025
Montreal Heart Institute
2025
Fifth Affiliated Hospital of Zhengzhou University
2025
Shanxi Academy of Medical Sciences
2023-2024
Shanxi Medical University
2023-2024
Queen's University
2024
McGill University
2020-2024
Since its first release over a decade ago, the MetaboAnalyst web-based platform has become widely used for comprehensive metabolomics data analysis and interpretation. Here we introduce version 5.0, aiming to narrow gap from raw functional insights global based on high-resolution mass spectrometry (HRMS). Three modules have been developed help achieve this goal, including: (i) LC-MS Spectra Processing module which offers an easy-to-use pipeline that can perform automated parameter...
miRNet is an easy-to-use, web-based platform designed to help elucidate microRNA (miRNA) functions by integrating users' data with existing knowledge via network-based visual analytics. Since its first release in 2016, has been accessed >20 000 researchers worldwide, ∼100 users on a daily basis. While version 1.0 was focused primarily miRNA-target gene interactions, it become clear that order obtain global view of miRNA functions, necessary bring other important players into the context...
A theoretical inverse relationship exists between osteogenic (bone forming) and adipogenic (fat mesenchymal stem cell (MSC) differentiation. This in theory partially underlies the clinical entity of osteoporosis, which marrow MSCs have a preference for adipose differentiation that increases with age. Two pro-osteogenic cytokines been recently studied each also possesses antiadipogenic properties: Sonic Hedgehog (SHH) NELL-1 proteins. In present study, we assayed potential additive effects...
The role and underlying mechanism of exosomes derived from human periodontal ligament stem cells (PDLSC) in osteogenesis are unclear. In the present study, we identified PDLSCs found that osteogenic induction can enhance ability PDLSC-derived promoting differentiation rat bone marrow (BMSCs). To investigate mechanism, analyzed exosomal miRNA expression profiles undifferentiated differentiated by RNA sequencing. results showed seventy-two miRNAs were upregulated thirty-five downregulated...
Metabolomics-based genome-wide association studies (mGWAS) are key to understanding the genetic regulations of metabolites in complex phenotypes. We previously developed mGWAS-Explorer 1.0 link single-nucleotide polymorphisms (SNPs), metabolites, genes and phenotypes for hypothesis generation. It has become clear that identifying potential causal relationships between phenotypes, as well providing deep functional insights, crucial further downstream applications. Here, we introduce 2.0...
Abstract Many cell responses that underlie the development, maturation, and function of tissues are guided by architecture mechanical loading extracellular matrix (ECM). Because stimulation must be transmitted through ECM architecture, synergy between these two factors is important. However, recapitulating physical microenvironmental cues in vitro remains challenging. To address this, a 3D magnetically actuated collagen hydrogel platform developed enables combined control stimulation. With...
Abstract Histone tail acetylation is a key epigenetic marker that tends to open chromatin folding and activate transcription. Despite intensive studies, precise roles of individual lysine in have only been poorly understood. Here, we revealed structural dynamics tri-nucleosomes with several histone states analyzed interactions DNA by performing molecular simulations at an unprecedentedly high resolution. We found versatile acetylation-dependent landscapes tri-nucleosome. The H4 H2A reduced...
Background. The screening and early detection of colorectal cancer (CRC) still remain a challenge due to the lack reliable effective serum biomarkers. Thus, this study is aimed at identifying biomarkers CRC that could be used distinguish from healthy controls. Methods. A prospective 1 : 2 individual matching case-control was performed which included 50 control subjects 98 patients. Untargeted metabolomic profiling conducted with liquid chromatography tandem mass spectrometry (LC-MS/MS)...
Abstract Neurodegenerative diseases are multi-faceted disorders influenced by and affecting more than just the brain nervous system. Here, we provide a review of potential links, including mechanistic genetic, between kidney health neurodegeneration, mainly dementia two most prevalent late-onset neurodegenerative disorders, Alzheimer’s disease Parkinson’s disease. We also discuss lines evidence from various study designs methodologies that either support or do not an association...
Abstract Intervertebral disk degeneration is a significant contributor to the development of spinal disorders. Previous studies have shown that senescence nucleus pulposus cells can worsen degradation intervertebral disks. Therefore, targeting may be promising therapeutic approach for treatment degeneration. This study investigated use exosomes from hypoxic umbilical cord-derived mesenchymal stem reverse and delay progression. MicroRNA sequencing revealed presence functional microRNAs, with...
IDH2 encodes a mitochondrial metabolic enzyme that converts isocitrate to α-ketoglutarate (α-KG) by reducing nicotinamide adenine dinucleotide phosphate (NADP+) NADPH and participates in the citric acid cycle for energy production. Notably, this gene has been shown be critical cell proliferation. The abnormal expression of reported several types cancer, mutations have identified gliomas acute myelogenous leukemia. overexpression endometrial, prostate testicular cancer as well Kashin-Beck...
Tens of thousands single-nucleotide polymorphisms (SNPs) have been identified to be significantly associated with metabolite abundance in over 65 genome-wide association studies metabolomics (mGWAS) date. Obtaining mechanistic or functional insights from these associations for translational applications has become a key research area the mGWAS community. Here, we introduce mGWAS-Explorer, user-friendly web-based platform help connect SNPs, metabolites, genes, and their known disease via...
Abstract Exposomics represents a systematic approach to investigate the etiology of diseases by formally integrating individuals’ entire environmental exposures and associated biological responses into traditional genotype-phenotype framework. The field is largely enabled various omics technologies which offer practical means comprehensively measure key components in exposomics. bottleneck exposomics has gradually shifted from data collection analysis. Effective easy-to-use bioinformatics...
Abstract Accurate computational estimate of the protein–ligand binding affinity is central importance in rational drug design. To improve accuracy molecular mechanics (MM) force field (FF) for simulations, we use a protein‐specific FF derived by fragment orbital (FMO) method and restrained electrostatic potential (RESP) method. Applying this FMO‐RESP to two proteins, dodecin, lysozyme, found that partial charges tend differ more significantly from standard AMBER isolated charged atoms. We...
Background: Long non-coding RNAs (lncRNAs) play critical roles in gastric cancer (GC) initiation progression. However, the biological function of lncRNA telomerase RNA component (TERC) remains unknown human GC. The present study sought to determine and underlying molecular mechanism TERC GC Methods: expression levels tissues cell lines were analyzed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). effects on proliferation, migration, invasion cells determined...