A5010806127- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Animal Virus Infections Studies
- Influenza Virus Research Studies
- Herpesvirus Infections and Treatments
- Hepatitis B Virus Studies
- Healthcare and Venom Research
- Long-Term Effects of COVID-19
- Pregnancy-related medical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Vitamin D Research Studies
- SARS-CoV-2 detection and testing
- Vector-borne infectious diseases
- Food Allergy and Anaphylaxis Research
- Inhalation and Respiratory Drug Delivery
- Poxvirus research and outbreaks
- Bacterial Infections and Vaccines
- vaccines and immunoinformatics approaches
Saarland University
2019-2025
Heterologous priming with the ChAdOx1 nCoV-19 vector vaccine followed by boosting a messenger RNA (BNT162b2 or mRNA-1273) is currently recommended in Germany, although data on immunogenicity and reactogenicity are not available. In this observational study we show that, healthy adult individuals (n = 96), heterologous regimen induced spike-specific IgG, neutralizing antibodies CD4 T cells, levels of which were significantly higher than after homologous boost 55) comparable magnitude to mRNA...
Abstract Comparative analyses of the immunogenicity and reactogenicity homologous heterologous SARS-CoV-2 vaccine-regimens will inform optimized vaccine strategies. Here we analyze humoral cellular immune response following vaccination strategies in a convenience cohort 331 healthy individuals. All regimens induce immunity to antigen. Immunity after with ChAdOx1-nCoV-19 followed by either BNT162b2 ( n = 66) or mRNA-1273 101) is equivalent more pronounced than mRNA-regimens 43 BNT162b2, 59...
Abstract Knowledge is limited as to how prior SARS-CoV-2 infection influences cellular and humoral immunity after booster-vaccination with bivalent BA.4/5-adapted mRNA-vaccines, whether vaccine-induced may indicate subsequent infection. In this observational study, individuals ( n = 64) showed higher anti-spike IgG-antibodies neutralizing titers, but the relative increase was significantly in non-infected 63). general, both groups activity towards parental strain than Omicron-subvariants...
Abstract Heterologous priming with the ChAdOx1-nCoV-19 vector-vaccine followed by boosting an mRNA-vaccine is currently recommended in Germany, although data on immunogenicity and reactogenicity are not available. Here we show that heterologous regimen induced spike-specific IgG, neutralizing antibodies, CD4 T-cells, which were significantly more pronounced than after homologous vector boost, higher or comparable magnitude to mRNA regimens. Moreover, CD8 T-cell levels vaccination both...
Abstract Knowledge on immunogenicity of the bivalent Omicron BA.4/5 vaccine in dialysis patients and effect a previous infection is limited. Therefore, vaccine-induced humoral cellular immunity was analyzed immunocompetent controls with without prior infection. In an observational study, 33 58 matched for age, sex status were recruited. Specific IgG, neutralizing antibody activity towards spike-antigen from parental SARS-CoV-2 Omicron-subvariants BA.1, BA.2 before 13-18 days after...
ABSTRACT Purpose High-performance sports training has been associated with immunomodulatory activity on vaccine-induced immunity in athletes. To date, it is unknown, whether athletes may affect immunogenicity of mRNA-based vaccines, as the vaccine antigen produced muscle. Methods In an observational study, 57 and controls were recruited before 2 weeks after second vaccination a COVID-19 mRNA vaccine. Spike-specific IgG-antibodies quantified using ELISA. Quantitative functional...
Embryonic growth and bone development depend on placental Ca2+ transport across the feto-maternal barrier to supply minerals fetus. The individual factors cellular mechanisms that regulate transfer, however, are only beginning emerge. We find -selective transient receptor potential vanilloid 6 (TRPV6) channel is expressed in trophoblasts of fetal labyrinth, yolk sac, maternal part placenta. Lack functional TRPV6 channels mother leads a reduced content both placenta embryo. uptake impaired...
Abstract Knowledge is limited as to how prior SARS-CoV-2 infection influences cellular and humoral immunity after booster-vaccination with bivalent BA.4/5-adapted mRNA-vaccines, whether vaccine-induced correlates subsequent infection. In this observational study, individuals (n=64) showed higher anti-spike IgG antibodies neutralizing titers, but the relative increase was significantly in non-infected (n=63). general, both groups activity towards parental strain than Omicron subvariants BA.1,...
Abstract To evaluate the immunogenicity of inactivated herpes zoster vaccine HZ/su in patients at increased risk for VZV-reactivation, we analyzed quantity and quality vaccine-induced cellular humoral immunity dialysis with uremic immunodeficiency. In this observational study, 29 39 immunocompetent controls underwent standard dual-dose vaccination. Blood samples were before two weeks after each vaccination, one year. Specific T-cells characterized stimulation VZV-gE peptides based on...
Abstract Knowledge on immunogenicity of the bivalent Omicron BA.4/5 vaccine in dialysis patients and effect a previous infection is limited. Therefore, vaccine-induced humoral cellular immunity was analyzed immunocompetent controls with without prior infection. In an observational study, 33 58 matched for age, sex status were recruited. Specific IgG, neutralizing antibody activity towards spike-antigen from parental SARS-CoV-2 subvariants BA.1, BA.2 before 13-18 days after vaccination. The...
Abstract The NVX-CoV2373-vaccine has recently been licensed, although data on vaccine-induced humoral and cellular immunity towards the parental strain variants of concern (VOCs) in comparison to dual-dose mRNA-regimens are limited. In this observational study including 66 participants, we show that NVX-CoV2373-induced IgG-levels were lower than after vaccination with BNT162b2 or mRNA-1273 (n=22 each, p=0.006). Regardless vaccine despite different IgG-levels, neutralizing activity VOCs was...
Abstract Head-to-head analyses of immunogenicity and reactogenicity between the authorized homologous vaccine-regimens heterologous combinations thereof are currently limited. Using a convenience cohort 331 healthy individuals, we show that humoral cellular immunity after vaccination with ChAdOx1-nCoV-19 followed by either BNT162b2 (n=66) or mRNA-1273 (n=101) is equivalent superior to mRNA-regimens (n=43 BNT162b2, n=59 mRNA-1273), more pronounced than (n=62). Levels spike-specific CD8 T...