A5069622899- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- Intramuscular injections and effects
- Hepatitis B Virus Studies
- Vagus Nerve Stimulation Research
- Animal Virus Infections Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- vaccines and immunoinformatics approaches
- Vaccine Coverage and Hesitancy
- Peripheral Neuropathies and Disorders
Saarland University
2021-2023
Heterologous priming with the ChAdOx1 nCoV-19 vector vaccine followed by boosting a messenger RNA (BNT162b2 or mRNA-1273) is currently recommended in Germany, although data on immunogenicity and reactogenicity are not available. In this observational study we show that, healthy adult individuals (n = 96), heterologous regimen induced spike-specific IgG, neutralizing antibodies CD4 T cells, levels of which were significantly higher than after homologous boost 55) comparable magnitude to mRNA...
Abstract Comparative analyses of the immunogenicity and reactogenicity homologous heterologous SARS-CoV-2 vaccine-regimens will inform optimized vaccine strategies. Here we analyze humoral cellular immune response following vaccination strategies in a convenience cohort 331 healthy individuals. All regimens induce immunity to antigen. Immunity after with ChAdOx1-nCoV-19 followed by either BNT162b2 ( n = 66) or mRNA-1273 101) is equivalent more pronounced than mRNA-regimens 43 BNT162b2, 59...
Individual doses of dual-dose vaccine-regimens are sequentially administered into the deltoid muscle, but little attention has so far been paid to immunological effects choosing ipsilateral or contralateral side for second dose.In an observational study, 303 previously naive individuals were recruited, who received dose COVID-19 vaccine BNT162b2 on either (n = 147) 156). Spike-specific IgG, IgG-avidity, and neutralizing antibodies quantified using ELISA a surrogate assay 2 weeks after 2. A...
Background: Individual doses of dual-dose vaccine-regimens are sequentially administered into the deltoid muscle, but little attention has so far been paid to immunological effects choosing ipsilateral or contralateral side for second dose.Methods: In an observational study, 303 previously naive individuals were recruited, who received dose COVID-19 vaccine BNT162b2 on either (n=147) (n=156). Spike-specific IgG and neutralizing antibodies quantified using ELISA a surrogate assay 2 weeks...
Abstract The NVX-CoV2373-vaccine has recently been licensed, although data on vaccine-induced humoral and cellular immunity towards the parental strain variants of concern (VOCs) in comparison to dual-dose mRNA-regimens are limited. In this observational study including 66 participants, we show that NVX-CoV2373-induced IgG-levels were lower than after vaccination with BNT162b2 or mRNA-1273 (n=22 each, p=0.006). Regardless vaccine despite different IgG-levels, neutralizing activity VOCs was...
Abstract Head-to-head analyses of immunogenicity and reactogenicity between the authorized homologous vaccine-regimens heterologous combinations thereof are currently limited. Using a convenience cohort 331 healthy individuals, we show that humoral cellular immunity after vaccination with ChAdOx1-nCoV-19 followed by either BNT162b2 (n=66) or mRNA-1273 (n=101) is equivalent superior to mRNA-regimens (n=43 BNT162b2, n=59 mRNA-1273), more pronounced than (n=62). Levels spike-specific CD8 T...