A5009025235- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Coronary Artery Anomalies
- Coronary Interventions and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Issues in Pregnancy
- Atrial Fibrillation Management and Outcomes
- Hemodynamic Monitoring and Therapy
- Kawasaki Disease and Coronary Complications
- Cardiac pacing and defibrillation studies
- Cardiovascular Health and Disease Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Vascular anomalies and interventions
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Pain Management and Treatment
- Cardiac Structural Anomalies and Repair
- Cerebrovascular and Carotid Artery Diseases
- Liver Disease Diagnosis and Treatment
IRCCS Policlinico San Donato
2016-2025
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2012-2016
Ferrarotto Hospital
2013-2016
EMO GVM Centro Cuore Columbus
2016
Istituto Neurologico Mediterraneo
2016
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2013-2016
Azienda Ospedaliera Universitaria Pisana
2013-2016
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2013-2016
Sapienza University of Rome
2016
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2016
Background— Conduction disturbances are relatively common after transcatheter aortic valve implantation. Previous data demonstrated an adverse impact of persistent left bundle-branch block (LBBB) surgical replacement. It is unclear whether new-onset LBBB may also the prognosis patients Methods and Results— Among 1060 treated with a CoreValve Revalving System implantation between October 2007 April 2011 in high-volume centers Italy, we analyzed those without or pacemaker at admission (879...
Background— Little is known of the prognostic significance mitral regurgitation (MR) on transcatheter aortic valve replacement (TAVR), impact TAVR MR severity, and variables associated with possible post-TAVR improvement in MR. We evaluated these issues a multicenter registry patients undergoing CoreValve Revalving System–TAVR. Methods Results— Among 1007 consecutive patients, 670 (66.5%), 243 (24.1%), 94 (9.3%) presented no/mild, moderate, severe MR, respectively. At 1 month after TAVR, or...
Background— Severe pulmonary hypertension (PH) is considered to negatively affect the outcome after transcatheter aortic valve replacement. However, a clear understanding of pattern, evolution, and clinical impact different grades PH in this setting lacking. Methods Results— A total 990 consecutive patients were enrolled 6 high-volume centers analyzed as follows: group 1, systolic artery pressure (sPAP) <40 mm Hg (346 patients; 35%); 2, sPAP 40 60 (426 43%); 3, >60 (218 22%). At 1...
Abstract Objectives To investigate paravalvular leak (PVL) and devices success rates according to aortic angle (AA) in patients undergoing transcatheter valve implantation (TAVI) with three new‐generation self‐expanding devices. Background The impact of on TAVI device PVL is controversial. Methods This retrospective study included 392 submitted for severe stenosis Portico, Evolut‐R Acurate‐NEO, available AA measurements at computed tomography (CT) angiography. was calculated from the...
Abstract Background Anomalous Aortic Origin of Coronary Arteries (AAOCA) is associated with myocardial ischemia and sudden cardiac death, particularly in young athletes. Although inducible investigation generally recommended, there no clear indication the most appropriate stress test, as ECG exercise test presents low diagnostic accuracy. Dobutamine-stress magnetic resonance (dsCMR) has been proposed a promising tool, but its application limited to pediatric populations. Objectives This...
Arterial access selection is crucial during transcatheter aortic valve implantation. When traditional femoral has been deemed unfeasible the left subclavian artery used successfully. In cases where even latter was ineligible, we opted, despite lack of any data, for right approach. We hereby present results first series available. Our aim to evaluate feasibility and performance CoreValve ReValving System (CRS) implantation via in patients with contraindication accesses.Among 300 who have...
Background New-generation transcatheter heart valves have been developed to reduce complications of aortic valve implantation (TAVI). With this study we sought compare procedural and 30-day outcomes the new-generation repositionable Boston Scientific Lotus (Lotus) balloon-expandable Edwards Sapien 3 (ES3) valves. Methods A total 315 patients with severe symptomatic stenosis undergoing transfemoral TAVI or ES3 included in two large Italian registries were considered for analysis. After...
Background: Transcatheter aortic valve replacement (TAVR) has determined a paradigm shift in the treatment of patients with severe stenosis. However, durability bioprostheses is still matter concern, and little known about management degenerated TAV. We sought to evaluate outcomes TAV treated by means second TAVR. Methods: The TRANSIT an international registry that included cases TAVR from 28 centers. Among around 40 000 participating centers, 172 underwent TAVR: 57 (33%) for mainly stenotic...
Right ventricular dysfunction (RVdy) is negatively associated with survival after left heart valve surgery. It unclear whether RVdy has the same impact in patients undergoing transcatheter aortic implantation (TAVI). We sought to evaluate prognostic of different grades on TAVI, and without concomitant (LVdy), possible TAVI RVdy.Among 870 consecutive severe symptomatic stenosis 226 (26%) presented a diagnosis RVdy. Patients were divided into three groups, Group 1: normal RV systolic function,...
BACKGROUND: Anomalous aortic origin of coronary artery (AAOCA) with intramural segment is associated risk sudden cardiac death, probably related to a compressive mechanism exerted by the aorta. However, compression occurrence and magnitude during cycle remain unknown. We hypothesized that (1) in end diastole, narrower, more elliptic, has greater resistance than extramural segment; (2) experiences further systole; (3) morphometry its systolic changes vary within different lumen cross-sections...
Abstract Anomalous aortic origin of the coronary artery (AAOCA) is a rare disease associated with sudden cardiac death, usually related to physical effort in young people. Clinical routine tests fail assess ischemic risk, calling for novel diagnostic approaches. To this aim, some recent studies propose blood flow (CBF) AAOCA by computational simulations but they are limited use data from literature retrieved normal subjects. overcome limitation and obtain reliable assessment CBF, we...
This report describes the case of previous type-A aortic dissection treated with placement a termino-terminal prosthesis, which developed large peri-prosthetic pseudoaneurysmatic sac, detected by CT, performed 2 years after surgery. raised suspicion communication between sac and lumen, but was not able to show it directly. Transthoracic echocardiography confirmed presence fistula, showing systo-diastolic color Doppler jet signal connecting these two structures.The complementary role...
Abstract Background Balloon post‐dilation (BPD) is a widely adopted strategy to optimize acute results of TAVI, with positive impact on both paravalvular leak and mean gradients. On the other hand, inflation balloon inside prosthetic leaflets may damage them increasing risk structural valve deterioration (SVD). Furthermore, BPD long‐term clinical outcomes hemodynamics yet unknown. Aims To evaluate durability in patients undergoing self‐expanding transcatheter implantation (TAVI). Methods...
Background A severe prosthesis-patient mismatch (PPM) is associated with adverse outcomes following transcatheter aortic valve replacement (TAVR) for de novo stenosis or a failed surgical bioprosthesis. The impact of PPM in patients undergoing TAV-in-TAVR unknown. Aim We sought to investigate the incidence and 1-year different grades TAV-in-TAVR. Materials methods TRANSIT-PPM an international registry, including cases degenerated TAVR treated second TAVR. severity, as well in-hospital,...
This study sought to investigate the procedural and mid-term outcomes of transcatheter aortic valve implantation for failed surgical bioprostheses (TAVI-ViV) with Portico device.Limited evidence coming from early experience on system does not allow fully assess safety efficacy this device in ViV patients.From January 2016 up June 2019, 56 consecutive patients undergoing TAVI-ViV were prospectively included our institutional TAVI database.The prevalent mechanism failure was stenosis (58.9%);...
Abstract Management of congenital coronary artery anomalies (CAA) is not standardized due to the variety conditions included and their rare prevalence. Detection CAA during myocardial infarction with non‐obstructive arteries (MINOCA) may induce clinicians address patient for surgery as in any algorithm 1,2 management MINOCA American Association Thoracic Surgery evidence‐based guidelines suggest surgical repair patients anomalous aortic origin a symptoms compatible ischaemia. 3 We present...
Transcatheter aortic valve replacement determined a paradigm shift in the treatment of high-risk patients with severe symptomatic stenosis. Notwithstanding impressive results first-generation prostheses, fast-paced technological evolution is taking place to overcome their limitations, particular vascular access damage and paravalvular leak. Nowadays, availability several different devices, expert operator can select right prosthesis for specific anatomical clinical situation. As 'One does...