A5028829827- Nanoplatforms for cancer theranostics
- Nosocomial Infections in ICU
- Clostridium difficile and Clostridium perfringens research
- Immune cells in cancer
- Advanced Nanomaterials in Catalysis
- Phagocytosis and Immune Regulation
- Gold and Silver Nanoparticles Synthesis and Applications
- Bacterial Identification and Susceptibility Testing
- Bladder and Urothelial Cancer Treatments
- Luminescence and Fluorescent Materials
- Nanoparticles: synthesis and applications
- Autophagy in Disease and Therapy
- Nanoparticle-Based Drug Delivery
- Advanced Photocatalysis Techniques
- Epigenetics and DNA Methylation
- Electrocatalysts for Energy Conversion
- Microscopic Colitis
- Copper-based nanomaterials and applications
- Chemistry and Chemical Engineering
- Nonlinear Optical Materials Studies
- Advanced biosensing and bioanalysis techniques
- Porphyrin and Phthalocyanine Chemistry
- Heme Oxygenase-1 and Carbon Monoxide
- Chalcogenide Semiconductor Thin Films
National Cheng Kung University
2019-2024
Chu Shang Show Chwan Hospital
2023
National Tsing Hua University
2023
China Medical University
2023
Taipei Medical University
2023
Taipei City Hospital
2023
Taipei Municipal YangMing Hospital
2023
National Pingtung University
2018-2022
Abstract Near infrared energy remains untapped toward the maneuvering of entire solar spectrum harvesting for fulfilling nuts and bolts hydrogen production. We report use Au@Cu 7 S 4 yolk@shell nanocrystals as dual-plasmonic photocatalysts to achieve remarkable production under visible near illumination. Ultrafast spectroscopic data reveal prevalence long-lived charge separation states both excitation. Combined with advantageous features nanostructures, achieves a peak quantum yield 9.4% at...
The escape of bladder cancer from immunosurveillance causes monotherapy to exhibit poor efficacy; therefore, designing a multifunctional nanoparticle that boosts programmed cell death and immunoactivation has potential as treatment strategy. Herein, we developed facile one-pot coprecipitation reaction fabricate cluster-structured nanoparticles (CNPs) assembled Fe3O4 iron chlorophyll (Chl/Fe) photosensitizers. This nanoassembled CNP, theranostic agent, could perform red-NIR fluorescence...
Lung cancer is considered among the deadliest cancers with a poor prognosis. Au@PG nanoparticles (NPs) are gold (Au)-based NPs featuring polyaniline-based glyco structure (PG) generated from polymerization of ortho-nitrophenyl-β-d-galactopyranoside (ONPG) promising M1 macrophage polarization activity, resulting in tumor remodeling and cold to hot microenvironment, which promotes cytotoxic T cell response inhibition. The combination anti-programmed death protein 1 (PD-1) therapy improved...
Cu@Cu2O@PSMA polymer nanoparticles (Cu@Cu2O@polymer NPs) with near-infrared (NIR) absorption were successfully synthesized in a single-step oxidation reaction of Cu@PSMA NPs at 100 °C for 20 min. The shape, structure, and optical properties the Cu@Cu2O@polymer tailorable by controlling parameters, example, using initial NP as template varying halide ion content, heating temperature, time. exhibited robust NIR between 650 710 nm possessed superior resistance water culture media. In vitro...
The discovery of different binding receptors to allow rapid and high-sensitivity detection via a noninvasive urine test has become the goal for urothelial carcinoma (UC) diagnosis surveillance. In this study, we developed new screening membrane receptor platform bladder cancer cells by integrating surface-enhanced Raman spectroscopy (SERS) with 4-aminothiophenol (4-ATP)-modified AuAg nanohollows upon NIR laser excitation. have an absorption band at ∼630 nm, slightly off-resonance 785 nm...
Cancer cells have a high demand for sugars and express diverse carbohydrate receptors, offering opportunities to improve delivery with multivalent glycopolymer materials. However, effectively delivering glycopolymers tumors while inhibiting cancer cell activity, altering cellular metabolism, reversing tumor-associated macrophage (TAM) polarization overcome immunosuppression remains challenging area of research due the lack reagents capable simultaneously achieving these objectives. Here,...
The facile and straightforward fabrication of NIR-responsive theranostic materials with high biocompatibility is still an unmet need for nanomedicine applications. Here, we used a natural photosensitizer, iron chlorophyll (Chl/Fe), the J-aggregate template-assisted synthesis Au@Chl/Fe nanorods stability. assembly amount Chl/Fe onto Au surface enabled red–NIR fluorescence monitoring tracking residential tumor lesions. moieties condensed on could change redox balance by photon induction...
Herein, we develop a series etching and atom codeposition process to fabricate concave double-shell AgAu (CD-AgAu) CD-AgAu:Pd nanocubes. High surface area edge activity from the CD nanostructure consisting of single hole appear in central area, 12 structures exhibit superior surface-enhanced Raman scattering (SERS). As investigating Pd dopants at with SERS electrochemistry, demonstrate that 2.8% Pd-doped CD-AgAu nanocubes perform impressive catalysis ≤30 s hydrogenation reaction by lowering...
The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most dyes are water-insoluble such that the derivatization modification these difficult. Herein, we demonstrated a simple platform for fabrication NPs designed with emissive properties by loading ten different (molar masses 479.1-1081.7 g/mol) into water-soluble polymer nanosponges composed poly(styrene-alt-maleic acid) (PSMA). result showed substantial improvement over commercial (3.7-50%...
Abstract Clostridioides difficile spores are considered as the major source responsible for development of C . infection (CDI), which is associated with an increased risk death in patients and has become important issue control nosocomial infections. Current treatment against CDI still relies on antibiotics, also damage normal flora increase recurrence. Therefore, alternative therapies that more effective bacteria urgently needed. Here, we designed oxidation process using H 2 O containing...
The tumor microenvironment (TME), where immunosuppressive cells such as tumor-associated macrophages (TAMs) proliferate, is the main cause of resistance to antineoplastic treatment for KRAS-driven lung cancer. In this study, we synthesized polymer-based nanoparticles composed a 16 nm-sized Au core and amphiphile, poly-(styrene-alt-maleic acid) (PSMA), via hydrothermal procedure carrying multi-receptor tyrosine kinase inhibitor, sitravatinib (Sit), in new nanodrug (Au@PSMA-Sit). Au@PSMA-Sit...
Abstract Poor drug delivery and an unresponsive tumor microenvironment (TME) hinder the treatment of glioblastoma (GBM) pancreatic cancer (PC). Targeting macrophage polarization through nanoparticle (NP) internalization represents a promising approach to regulate TME enhance immunotherapy. Here, we introduce galactose -based NP designed for monocarboxylate transporter 4 (MCT-4)-mediated transport in cells, promoting M2-to-M1 disrupting cell mitochondrial function trigger apoptosis. The...
Abstract The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most chromophores are water-insoluble, therefore, the derivatization modification these difficult. Herein, we demonstrated a simple platform for fabrication nanoemitters by loading ten different dyes (molar masses 479.1-1081.7 g/mol) into water-soluble polymer nanosponges composed poly(styrene-alt-maleic acid) (PSMA). This nanolization strategy enables incorporation small commercial...