The escape of bladder cancer from immunosurveillance causes monotherapy to exhibit poor efficacy; therefore, designing a multifunctional nanoparticle that boosts programmed cell death and immunoactivation has potential as treatment strategy. Herein, we developed facile one-pot coprecipitation reaction fabricate cluster-structured nanoparticles (CNPs) assembled Fe3O4 iron chlorophyll (Chl/Fe) photosensitizers. This nanoassembled CNP, theranostic agent, could perform red-NIR fluorescence...

Photothermal therapy (PTT) is a minimally invasive procedure that uses nanoparticles to produce heat from light kill cancer cells. This review highlights the mechanism of PTT, and results obtained for improved therapeutic effect PTT using inorganic platform.

This work presents the development of a facile ligand-assisted hydrothermal reaction for preparation NIR-activated Fe3O4 nanostructures that can directly upgrade iron oxide with MR contrast ability to be MRI/photothermal theranostic agent.

We demonstrated the plasmonic metallic nanostructure fabricated by direct nanoimprinting of gold nanoparticles (AuNPs). This approach combines patterning and lift-off processes into a simple one-step process without need for expensive lithographies stringent requirement nanostructures. Good imprinting integrity was accomplished with negligible residual layer. The dynamic optical responses imprinted pillars from AuNPs to bulk material during annealing were investigated. localized surface...

Atherosclerosis is a multifactorial inflammatory disease that may progress silently for long period, and it also widely accepted as the main cause of cardiovascular diseases. To prevent atherosclerotic plaques from generating, imaging early molecular markers quantifying extent progression are desired. During inflammation, circulating monocytes leave bloodstream migrate into incipient lipid accumulation in artery wall, following conditioning by local growth factors proinflammatory cytokines;...

Cu@Cu2O@PSMA polymer nanoparticles (Cu@Cu2O@polymer NPs) with near-infrared (NIR) absorption were successfully synthesized in a single-step oxidation reaction of Cu@PSMA NPs at 100 °C for 20 min. The shape, structure, and optical properties the Cu@Cu2O@polymer tailorable by controlling parameters, example, using initial NP as template varying halide ion content, heating temperature, time. exhibited robust NIR between 650 710 nm possessed superior resistance water culture media. In vitro...

The discovery of different binding receptors to allow rapid and high-sensitivity detection via a noninvasive urine test has become the goal for urothelial carcinoma (UC) diagnosis surveillance. In this study, we developed new screening membrane receptor platform bladder cancer cells by integrating surface-enhanced Raman spectroscopy (SERS) with 4-aminothiophenol (4-ATP)-modified AuAg nanohollows upon NIR laser excitation. have an absorption band at ∼630 nm, slightly off-resonance 785 nm...

Herein, we present a one-pot hydrothermal approach for synthesizing metal-organic framework-derived copper (II) benzene-1,3,5-tricarboxylate (Cu-BTC) nanowires (NWs) using dopamine as the reducing agent and precursor polydopamine (PDA) surface coating formation. In addition, PDA can act PTT enhance NIR absorption, producing photothermal effects on cancer cells. These NWs displayed conversion efficiency of 13.32% after exhibited good stability. Moreover, with suitable T1 relaxivity...

The combination of the functions near infrared-triggered molecule release and chemo-photothermal therapy improved therapeutic effect, but clarification cancer damage pathway in terms protein levels has yet to be well studied. In this study, we developed a polymer encapsulation synthesis Au/Fe3O4@polymer nanoparticles as Swiss army knife integrate infrared absorption, magnetism, doxorubicin (DOX) loading ability into single package. By exposing possessed photothermal therapy, exhibiting...

Photodynamic therapy (PDT) holds tantalizing prospects of a prominent cancer treatment strategy. However, its efficacy remains limited by virtue the hypoxic tumor microenvironment and inadequate tumor-targeted delivery photosensitizers, these can be further exacerbated lack development well-controlled nitric oxide (NO) release system at target site. Inspired Chinese medicine, we propose revealing new keratin application. Keratin has garnered attention as an NO generator; however, oncological...

The facile and straightforward fabrication of NIR-responsive theranostic materials with high biocompatibility is still an unmet need for nanomedicine applications. Here, we used a natural photosensitizer, iron chlorophyll (Chl/Fe), the J-aggregate template-assisted synthesis Au@Chl/Fe nanorods stability. assembly amount Chl/Fe onto Au surface enabled red–NIR fluorescence monitoring tracking residential tumor lesions. moieties condensed on could change redox balance by photon induction...

Mie resonances have recently attracted much attention in research on dielectric metasurfaces, owning to their enriched multipole resonances, negligible optical loss, and efficient light emitter integration. Although there is a rapid advancement this field, some fundamental developments are still required provide simpler more versatile paradigm for photoluminescence (PL) control. In work, we proposed that an all-dielectric coherent metasurface can engineer the PL response by tuning array...

Here, we utilized inert Cu@poly(styrene-alt-maleic acid) (PSMA) nanoparticles (NPs) as a potential starting material, enabling restrictions on chemical etching and resistance to external toxic surfactant adsorption. Such modulated oxidation–dissolution of Cu allowed preservation the original nano-Cu shape facilitated subsequent deposition Au atoms form AuCu nanoshells with tunable Au/Cu ratio. An increase in concentration fraction at surface nanolayer AuxCu1–x (x = 0.41–0.86) could intensify...

Photodynamic therapy (PDT) is a promising treatment for malignancy. However, the low molecular solubility of photosensitizers (PSs) with accumulation at borderline malignant potential lesions results in tardy and ineffective management recurrent urothelial carcinoma. Herein, we used tannic acid (TNA), green precursor, to reduce HAuCl4 order generate Au@TNA core-shell nanoparticles. The photosensitizer methylene blue (MB) was subsequently adsorbed onto surface nanoparticles, leading...

Abstract The development of fluorescent iron oxide nanomaterials is highly desired for multimodal molecular imaging. Instead incorporating dyes on the surface oxides, a ligand‐assisted synthesis approach developed to allow near‐infrared (NIR) fluorescence in Fe 3 O 4 nanostructures. Using trimesic acid (TMA)/citrate‐mediated synthesis, fabricated nanostructures can generate NIR two‐photon florescence (TPF) peak around 700 nm under excitation by 1230‐nm femtosecond laser. By tailoring...

In this work we developed methylene blue-immobilized copper-iron nanoparticles (MB-CuFe NPs) through a facile one-step hydrothermal reaction to achieve better phototherapeutic effect. The Fe/Cu ratio of the CuFe NPs was controllable by merely changing loading amount iron precursor concentration. could serve as Fenton catalyst convert hydrogen peroxide (H2O2) into reactive oxygen species (ROS), while superparamagnetic properties also suggest magnetic resonance imaging (MRI) potential....

Scanning electrochemical microscopy (SECM) is one of the scanning probe techniques that has attracted considerable attention because its ability to interrogate surface morphology or reactivity. However, quality SECM images generally depends on sizes electrodes and many uncontrollable factors. Furthermore, manipulating fragile glass ultramicroelectrodes blurred sometimes frustrate researchers. To overcome challenges modern SECM, we developed novel soft gold probes then established AI-assisted...

The photon energy-dependent selectivity of photocatalytic CO2-to-CO conversion by CsPbBr3 nanocrystals (NCs) and CsPbBr3/g-C3N4 nanoheterostructures (NHSs) was demonstrated for the first time. surficial capping ligands NCs would adsorb CO2, resulting in carboxyl intermediate to process via carbene pathways. type-II energy band structure at heterojunction NHSs separate charge carriers, promoting efficiency conversion. electron consumption rate found intensively depend on constant interfacial...