A5016944273- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Cardiovascular and exercise physiology
- Cardiovascular Health and Disease Prevention
- Cardiovascular Effects of Exercise
- Birth, Development, and Health
- Pulmonary Hypertension Research and Treatments
- Blood Pressure and Hypertension Studies
- Cardiovascular Issues in Pregnancy
- Cardiac Valve Diseases and Treatments
- Advanced X-ray and CT Imaging
- Cardiovascular Disease and Adiposity
- Ultrasound in Clinical Applications
- Aortic Thrombus and Embolism
- Physical Activity and Health
- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Body Composition Measurement Techniques
- Retinal and Optic Conditions
- Heart Rate Variability and Autonomic Control
- Biomarkers in Disease Mechanisms
- Retinal Imaging and Analysis
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
University of Oxford
2018-2025
Massachusetts Institute of Technology
2024-2025
Imam Abdulrahman Bin Faisal University
2018-2023
John Radcliffe Hospital
2018-2023
Hammersmith Hospital
2018-2019
Imperial College London
2018-2019
The purpose of this study was to establish whether an artificially intelligent (AI) system can be developed automate stress echocardiography analysis and support clinician interpretation.Coronary artery disease is the leading global cause mortality morbidity remains one most commonly used diagnostic imaging tests.An automated image processing pipeline extract novel geometric kinematic features from echocardiograms collected as part a large, United Kingdom-based prospective, multicenter,...
Heart failure (HF) with mid-range ejection fraction (HFmrEF) shares similar diagnostic criteria to HF preserved (HFpEF). Whether left atrial (LA) function differs between HFmrEF and HFpEF is unknown. We, therefore, used 2D-speckle-tracking echocardiography (2D-STE) assess LA phasic in patients HFmrEF. Consecutive outpatients diagnosed according current European recommendations were prospectively enrolled. There 110 61 sinus rhythm, 37 controls matched by age. was analysed using 2D-STE....
BackgroundExercise is advised for young adults with elevated blood pressure, but no trials have investigated efficacy at this age. We aimed to determine whether aerobic exercise, self-monitoring and motivational coaching lowers pressure in group.MethodsThe study was a single-centre, open, two-arm, parallel superiority randomized clinical trial open community-based recruitment of physically-inactive 18–35 year old awake 24 h 115/75mmHg-159/99 mmHg BMI<35 kg/m2. The took place the...
Cerebrovascular changes are already evident in young adults with hypertension and exercise is recommended to reduce cardiovascular risk. To what extent benefits the cerebrovasculature at an early stage of disease remains unclear. investigate whether structured aerobic increases brain vessel lumen diameter or cerebral blood flow (CBF) associated CBF. Open, parallel, two-arm superiority randomized controlled (1:1) trial TEPHRA study on intention-to-treat basis. The MRI sub-study was optional...
Abstract Aims Accurate staging of hypertension-related cardiac changes, before the development significant left ventricular hypertrophy, could help guide early prevention advice. We evaluated whether a novel semi-supervised machine learning approach generate clinically meaningful summary score remodelling in hypertension. Methods and results A contrastive trajectories inference was applied to data collected from three UK studies young adults. Low-dimensional variance identified 66...
Hypertension prevalence in young adults has increased and is associated with incidence of cerebrovascular cardiovascular events middle age. However, there significant debate regards how to effectively manage adult hypertension recommendation target lifestyle intervention. Surprisingly, no trials have investigated whether advice developed for blood pressure control older effective these younger populations. TEPHRA an open label, parallel arm, randomised controlled trial high normal elevated...
Premature birth is an independent predictor of long-term cardiovascular risk. Individuals affected are reported to have a lower rate [Formula: see text]o
•FoCUS can be used in low-resource obstetric settings.•Trained obstetricians acquired high-quality images with portable cardiac ultrasound.•Images were interpreted remotely by experts using an image interpretation protocol.•Most of the views (64%-79%) graded as good quality experts.•Agreement was 78% on diagnosis between focused and standard echocardiography. BackgroundCardiac complications are a leading cause maternal death. Cardiac imaging echocardiography is important for prompt...
Background Preterm birth affects 10% of live births and is associated with an altered left ventricular right phenotype increased cardiovascular disease risk in young adulthood. Because atrial (LA) (RA) volume function are known independent predictors outcomes, we investigated whether these were preterm-born adults. Methods Results Preterm-born (n=200) term-born (n=266) adults aged 18 to 39 years underwent magnetic resonance imaging. LA RA maximal minimal volumes (absolute, indexed body...
To investigate the left ventricular response to exercise in young adults with hypertension, and identify whether this can be predicted from changes atrial function at rest.A total of 127 aged 18-40 years who completed clinical blood pressure assessment echocardiography phenotyping rest during cardiopulmonary testing, were included. Measurements compared between participants suboptimal ≥120/80mm Hg (n = 68) optimal <120/80mm 59). Left systolic was obtained an apical four chamber view, while...
Background A subpopulation of endothelial progenitor cells called colony-forming (ECFCs) may offer a platform for cellular assessment in clinical studies because their remarkable angiogenic and expansion potentials vitro. Despite cell function being influenced by cardiovascular risk factors, no have yet provided comprehensive proteomic profile to distinguish functional (ie, more expansive cells) versus dysfunctional circulating ECFCs young adults. The aim this study was provide detailed...
ABSTRACT Background Young-adults with endothelial cell dysfunction are more likely to develop elevated blood pressure. We tested the hypothesis that this relates development of structural microvascular impairments by studying associations between circulating colony-forming (ECFC) and markers, as well identifying related molecular mechanisms. Methods Peripheral ECFCs were isolated from 32 subjects (53% men, 28±4 years old) using Ficoll density gradient centrifugation method. Participants...
Abstract Background People born preterm (&lt;37 weeks’ gestation) have a potentially adverse cardiac phenotype that progresses with blood pressure elevation and may explain their increased risk of early heart failure cardiovascular-related mortality. It remains unknown whether lifestyle or pharmacological interventions lead to beneficial left ventricle (LV) right (RV) structural and/or functional changes in preterm-born adults. Purpose To determine adults elevated stage 1 hypertension...
ABSTRACT Background People born preterm (<37 weeks’ gestation) have a potentially adverse cardiac phenotype that progresses with blood pressure elevation. We sought to determine whether preterm-born adults elevated and stage 1 hypertension exhibit similar structural functional remodeling following 16-week aerobic exercise intervention as their term-born peers. Methods conducted an open, parallel, two-arm superiority randomized controlled (1:1) trial in n=203 aged 18-35 years old or...
Abstract Background Previous studies have shown that prematurity leads to altered right ventricular (RV) geometry and performance with persistent impairments in RV systolic function young adulthood. It is unknown what extent pulmonary physiology impacts these findings. Purpose To better quantify known alterations morphology preterm-born adults determine changes are influenced by the circulation. Methods A total of 101 normotensive (n=47, mean gestational age 32.8±3.2 weeks) term-born (n=54)...