The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an emergent infectious pathogen causing disease called corona virus 2019 (COVID-19). Virus transmission may occur by contact, droplet, airborne or via contaminated surfaces. In efforts to effectively control the COVID-19 outbreak, world health organization (WHO) and Saudi Ministry of Health (MOH) have advised public practice protective measures reduce incidence infection. These include hand washing, wearing masks gloves...

While it is reported that COVID-19 patients are more prone to secondary bacterial infections, which strongly linked the severity of complications disease, coinfections associated with not widely studied. This work aimed investigate prevalence and antibiotic resistance profiles among hospitalised patients. Age, gender, weight, identities, sensitivity were collected retrospectively for 108 admitted intensive care unit (ICU) non-ICU ward a single center in Saudi Arabia. ICU (60%) showed...

Despite the advanced development in field of drug discovery and design, fighting infectious non-infectious diseases remains a major worldwide heath challenge due to limited activity currently used drugs. Nevertheless, recent years, approach designing nanoparticles for therapeutic applications has gained more interest promise future use. Thus, current study is focused on evaluation A. judaica extract chitosan loaded (CNPsLE) potential antimicrobial anticancer activities. The HPLC analysis...

The nanostructures synthesized using the green chemistry method have recently attracted attention of scientists due to their significance in many scientific domains. This work provides an overview biosynthesis zinc oxide (ZnO) nanosheets (NSs) Phyllanthus emblica plant (PEP) extract. X-ray diffraction analysis (XRD), photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) were used analyze ZnO-NSs. Evaluation antibacterial activity...

Clinical multi-drug-resistant bacteria continue to be a serious health problem. Plant-derived molecules are an important source of bioactive compounds counteract these pathogenic bacteria. In this paper, we studied the chemical composition methanol (80%) extract from Pithecellobium dulce seed (Hail, Saudi Arabia) and its ability inhibit growth clinically relevant Molecular docking analysis was performed predict best with low binding energy high affinity interact two Staphylococcus aureus...

Objective: Social distancing measures, such as stay-at-home, are currently implemented to control the COVID-19 pandemic in many countries, including Saudi Arabia. The aim of this study was, therefore, evaluate awareness and adherence population these measures. Methods: A web-based questionnaire was designed with 16 questions (eight related demographics, three social (stay-at-home) five overall practice distancing). Results: total 5105 participants completed survey [58.4% females, 66.3% young...

Urinary tract infections (UTIs) are among the most common that require antibiotic intervention. Antibiotic surveillance programs crucial to assess resistance patterns of microorganisms associated with UTIs and tailor therapy accordingly. Therefore, aim current study is investigate prevalence uropathogens their antimicrobial susceptibility in Ha'il region.We conducted a retrospective two main hospitals over 5-year period (January 2015 December 2019). Laboratory reports clinical data patients...

The biological properties of plant oils are improved by their conversion to nanoemulsions (NEs). This study evaluated the antimicrobial, antioxidant, and anti-hemolytic efficacy coconut salad rocket NEs. result gas chromatography-mass spectroscopy analysis showed varied constituents such as palmitic acid, trimethylsilyl ester; 2,3-bis(acetyloxy)propyl laurate in oil, 2-lauro-1,3-didecoin, n-butyl laurate; laurin, tri-; laurin oil. NEs diameter was 24.6 29.2 nm, respectively. More inhibitory...

Sidr honey is a valuable source of bioactive compounds with promising biological properties. In the present study, antimicrobial, antioxidant, and anti-quorum sensing properties Saudi were assessed, along phytochemical analysis, via gas chromatography–mass spectrometry (GC-MS). silico study was also carried out to drug-likeness identified their affinity known target proteins assessed using molecular docking approach. The results showed that exhibited antibacterial activity, MIC values...

Blood plays a major role in transmitting infectious diseases such as hepatitis C virus (HCV), human immunodeficiency (HIV), B (HBV), syphilis, malaria, and many others. Thus, this study sought to evaluate the distribution of HCV, HIV, malaria among blood donors Yemen. This is cross-sectional study, conducted on at national center donors' specimens were serologically tested for presence anti-HCV anti-HIV antibodies, well anti-Treponema pallidum, anti-Plasmodium falciparum, vivax. A total...

Honey has a history of medical use and is known as bio-alternative therapy. This research assessed the phytochemical biological activity grade manuka honey (MH). Gas chromatography–mass spectrometry (GC–MS) was chosen to investigate bioactive compounds MH. The DPPH ABTS free radical scavenging beta-carotene antioxidant activities well antibacterial antibiofilm effects against S. aureus, B. subtilis, E. coli P. aeruginosa were all determined. Furthermore, gauge anticancer properties MH, MTT...

Honey exhibited potential antimicrobial activity against multidrug resistant (MDR) bacteria that continues to be a serious health problem. We reported the in-vitro of Saudi Sumra honey clinical pathogenic and fungi, antibiofilm, anti-quorum-sensing (QS) antioxidant activities in relation its phytochemical composition assessed by gas chromatography-mass spectrometry (GC-MS). Broth dilution method scavenging 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) 2,2′-azino-bis...

Infections caused by multi-drug-resistant bacteria in patients with chronic diseases have been associated high mortality and morbidity. While few reports evaluated bacterial infections multiple disease patients, the focus of current study was to investigate prevalence susceptibility profiles causative strains among various groups suffering from diseases. Microbiological cancer, diabetes mellitus, cardiovascular diseases, kidney skin burns were retrospectively collected a tertiary hospital...

Introduction. Against the backdrop of increasing resistance to conventional antibiotics, bacteriocins represent an attractive alternative, given their potent activity, novel modes action and perceived lack issues with resistance. Aim. In this study, nature antibacterial activity a clinical isolate Streptococcus gallolyticus was investigated. Methods. Optimization production inhibitor from strain AB39 performed using different broth media supplements. Purification carried out size exclusion,...

Although Sumra and Sidr Saudi honey is widely used in traditional medicine due to its potent activity, it unknown whether prolonged usage has impact upon bacterial virulence or leading reduced antibiotic sensitivity. Thus, the study aims investigate effect of (repeated) in-vitro exposure on susceptibility profiles biofilm formation pathogenic bacteria.Several bacteria, including Staphylococcus aureus, Escherichia coli, Acinetobacter baumannii, were exposed ten times [passaged (P10)]to Sider...

Healthcare workers (HCWs) are the backbone of healthcare system and a skilled healthy workforce is vital during health crisis, such as present coronavirus disease 2019 (COVID-19) pandemic. at higher risk exposure to transmission severe acute respiratory coronavirus-2 (SARS-CoV-2). Hence, HCWs should possess good knowledge attitudes toward COVID-19 protect not only themselves but also their colleagues, families larger community. Thus, current study aims assess practice protective measures by...

Neonatal infections including sepsis and urinary tract are considered among the leading causes of mortality in neonatal intensive care units (NICU). Thus, use empiric antibiotics is very important infected neonates success this practice mainly reliant on availability an up-to-date antibiogram for currently used antibiotic drugs. In study, we aim to determine bacteriological profile susceptibility pattern bacteria isolated from blood or/and urine cultures belonging patients at NICU. A total...

Antimicrobial resistance in Escherichia coli presents a global challenge associated with nosocomial infections and increased mortality rates. Understanding profiles is crucial for guiding treatment strategies ensuring effective antibiotic use. This study aimed to investigate the prevalence vitro of E. community-acquired infections. Various clinical samples from 700 patients were cultured on MacConkey’s medium blood agar. The disk diffusion method was used determine susceptibility profile...

Plant-derived compounds are renowned for their remarkable pharmacological properties, holding immense promise therapeutic interventions in human health. In this study, we aimed to assess the antimicrobial, anti-hemolytic, antioxidant, and wound healing attributes of watercress oil incorporated into Vaseline gel (OLG) compared alone. OLG was formulated through a meticulous process involving addition under agitation conditions. High-performance liquid chromatography analysis unveiled rich...

Overexpression of the thymidine phosphorylase (TP) enzyme induces angiogenesis, which eventually leads to metastasis and tumor growth. The crucial role TP in cancer development makes it an important target for anticancer drug discovery. Currently, there is only one US-FDA-approved drug, i.e., Lonsurf, a combination trifluridine tipiracil, treatment metastatic colorectal cancer. Unfortunately, numerous adverse effects are associated with its use, such as myelosuppression, anemia, neutropenia....

The failure to treat infectious diseases due the continual emergence of drug-resistant microbes poses a huge and serious challenge for human health globally. Currently, discovery development natural therapeutic compounds are attracting considerable attention from researchers worldwide. In this project, two types pollen grains (maize clover) were evaluated potential antimicrobial activities. Extracts both purified using HPLC, which has been shown have numerous phenolic flavonoid compounds....

Successful empirical antibiotic therapy for infected patients with multi drug resistant bacteria (MDR) can be challenging task in various healthcare settings, including neonatal and pediatric intensive care units (NICU PICU, respectively), unless an up-to-date comprehensive local antibiogram data is available. Thus, this project aimed to investigate the prevalence of MDR among PICU NICU as well identification risk factors associated recovered bacteria. This was a retrospective study admitted...