A5070069431- Autism Spectrum Disorder Research
- Child Nutrition and Feeding Issues
- Attention Deficit Hyperactivity Disorder
- Family and Disability Support Research
- Child Development and Digital Technology
- Genetics and Neurodevelopmental Disorders
- Gut microbiota and health
- Functional Brain Connectivity Studies
- Infant Development and Preterm Care
- Neural and Behavioral Psychology Studies
- Breastfeeding Practices and Influences
- Biotin and Related Studies
- COVID-19 and Mental Health
- Children's Physical and Motor Development
- Antioxidant Activity and Oxidative Stress
- Viral gastroenteritis research and epidemiology
- Clostridium difficile and Clostridium perfringens research
- COVID-19 diagnosis using AI
- Neural dynamics and brain function
- Nerve injury and regeneration
- Reliability and Agreement in Measurement
- Retinopathy of Prematurity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Pediatric Pain Management Techniques
- Mosquito-borne diseases and control
Zhengzhou Children's Hospital
2021-2025
Zhengzhou University
2021-2025
Shenzhen Maternity and Child Healthcare Hospital
2022
High prevalence of sleep problems have been reported in children with Autism Spectrum Disorder (ASD). This study aims to investigate the conditions ASD China, and explore relationship between common core symptoms developmental levels.Using a cross-sectional design, we included 2 7-year-old from 13 cities China: 1310 1158 typically-developing (TD) children. The neurodevelopmental level was evaluated revised Children Neuropsychological Behavior Scale (CNBS-R2016). were diagnosed DSM-5 Child...
Autism spectrum disorder (ASD) is a neurodevelopmental disorder, and show striking male bias in prevalence. Vitamin A (VA) essential for brain development, abnormalities its metabolite retinoic acid are associated with the pathophysiology of ASD. This national multicenter study was conducted to investigate relationship between serum VA level core symptoms ASD children whether there still sex differences.A total 1,300 1,252 typically-developing (TD) controls aged 2-7 years old from 13 cities...
Background Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders among children. Pharmacotherapy has been primary treatment for ADHD, supplemented by behavioral interventions. Digital and exercise interventions are promising nonpharmacologic approaches enhancing physical psychological health children with ADHD. However, combined impact digital therapies remains unclear. Objective The aim this study was to determine whether BrainFit, a novel...
Abstract This study aims to explore the psychosocial and behavioral problems of children adolescents in early stage reopening schools. In this national cross-sectional study, a total 11072 students from China were naturally divided into two groups based on their schooling status: reopened schools (RS) home (HS) group. The functioning measured by Achenbach Child Behaviour Checklist (CBCL) compared these groups. Multivariable logistic regression analyses conducted independent predictors...
Abstract Background We aimed to compare differences in infant feeding patterns (breastfeeding and complementary food supplementation) between children with the autism spectrum disorder (ASD) typically developing (TD) through a multicentre study. The relationship these later core symptoms neurodevelopment ASD was also investigated. Methods analysed breastfeeding 1389 1190 TD children. Children Neuropsychological Behavior Scale-Revision 2016 (CNBS-R2016) used assess neurodevelopmental levels....
ABSTRACT Vitamin A deficiency remains a major public health problem worldwide, particularly among young children. Capillary blood has the potential for application in vitamin assessment. The aim of this study is to validate accuracy capillary assessing nutritional status Venous and samples were simultaneously collected from 1366 healthy children under 7 years age across 12 regions China. Retinol was measured using high‐performance liquid chromatography‐mass spectrometry (HPLC‐MS/MS)....
Background and Objective: Autism spectrum disorder (ASD) refers to a heterogeneous set of neurodevelopmental disorders with diverse symptom severity comorbidities. Although alterations in gut microbiota have been reported individuals ASD, it remains unclear whether certain microbial pattern is linked specific or comorbidity ASD. We aimed investigate the associations between social impairment cognitive functioning children Methods: A total 261 age-matched children, including 138 diagnosed 63...
Motor disturbance, as a related symptom of autism spectrum disorders (ASD), has not received the attention it deserves. We aimed to investigate different degrees motor developmental delay and influencing factors in Chinese preschool children with ASD, order enhance people's awareness ASD children. recruited 1,256 aged 2-6 years from China Multi-Center Preschool Autism Project (CMPAP). investigated overall status neurodevelopment through Revised Children Neuropsychological Behavior Scale...
Abstract Background High serotonin (5-hydroxytryptamine [5-HT]) blood levels are the most reliable and frequently replicated biomarker for autism spectrum disorders (ASDs). However, their differential influence on core ASD symptoms in males females remains unclear. This study aimed to investigate changes 5-HT children with assess compare its neurodevelopment of boys girls. Methods Herein, 1,457 1,305 typically developing (TD) controls (age = 2–7 years) were enrolled from 13 cities across...
Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Folate has been demonstrated to be associated with ASD. However, current studies on the correlation between folate and symptoms of children ASD have inconsistent conclusions, use mainly small samples, lack age-stratified analysis. This study aimed explore association serum autistic at different age groups from multi-center perspective. Methods: We enrolled 1,300 1,246 typically developing (TD) under 7 years...
The interactions between the microbiota and human host can affect physiological functions of organs (such as brain, liver, gut, etc.). Accumulating investigations indicate that imbalance microbial community is closely related to occurrence development diseases. Thus, identification potential links microbes diseases provide insight into pathogenesis In this study, we propose a deep learning framework (MDAGCAN) based on graph convolutional attention network identify microbe-disease...
Hand, foot and mouth disease (HFMD) is a common infectious in western Asia area the full range of long-term sequelae HFMD remains poorly described. We conducted retrospective hospital-based cohort study patients with central nervous system (CNS) complications caused by EV-A71 or CV-A16 between 2010 2016. Patients were classified into three groups, including CNS only, autonomic (ANS) dysregulation, cardiorespiratory failure. Neurologic examination, neurodevelopmental assessments, Magnetic...
Autism spectrum disorder (ASD) is a complicated diffuse developmental that commonly involves gastrointestinal distress and dysbacteriosis. Emerging lines of evidence have shown faecal microbiota transplantation (FMT) to be potential therapeutic strategy for improving the clinical outcomes patients with ASD by re-establishing their intestinal microflora. We are undertaking first-ever multicentre, double-blind, randomised controlled trial FMT treatment children both symptoms will assess...
The present study investigated the age of diagnosis, treatment and demographic factors Chinese children with autism spectrum disorders (ASD), to provide a scientific basis for early detection, intervention ASD.A total 1500 ASD aged 2-7 years old from 13 cities in China were administered questionnaires examine their treatment, basic family information. Childhood Autism Rating Scale (CARS) was used measure symptoms severity children, Children Neuropsychological Behavior Scale-Revision 2016...
Abstract Background Attention deficit/hyperactivity disorder (ADHD) has been identified as a risk factor for obesity in both children and adolescents. However, the mechanisms underlying relationship between ADHD are still unclear. This study aimed to test theoretical model of whether anxiety/depression is an intermediary ADHD-obesity relationship. Methods Data were derived from National Health Interview Survey (NHIS), principal source information on health civilian noninstitutionalized...
This study aimed to investigate the prevalence of developmental regression in children with Autism Spectrum Disorder (ASD) and explore its relationship disease severity. We finally included 1,027 ASD aged 2-5 years from 13 cities China: 138 regressive 889 non-regressive ASD. The Social Responsiveness Scale (SRS), Behavior Checklist (ABC), Child Rating (CARS), Children Neuropsychological Behavioral Scale-Revision 2016 (CNBS-R2016) were used evaluate core symptoms status two groups. Among...
Abstract Background Autism spectrum disorder (ASD) is a group of clinically heterogenic neurodevelopmental disorders, with intellectual disability being one its common comorbidities. No large-sample, multicenter study has focused on the aspect preschoolers ASD. This investigated characteristics ASD in China and explored association between them core symptoms. Methods We enrolled 1019 aged 2–7 years old from 13 cities around May 2018 December 2019, used revised Children Neuropsychological...
Autism spectrum disorders (ASD) are a group of complex neurodevelopmental with unclear etiologies. Our recent work indicated that maternal exposure to triclosan (TCS) significantly increased the autistic-like behavior in rats, possibly through disrupting neuronal retinoic acid signaling. Although environmental endocrine disruptors (EEDs) have been associated autism humans, relationship between TCS, one EEDs found antibacterial daily necessities, and has received little attention. The aims...