A5081727479- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Diabetes and associated disorders
- MicroRNA in disease regulation
- Systemic Sclerosis and Related Diseases
- Dialysis and Renal Disease Management
- Extracellular vesicles in disease
- Advanced Glycation End Products research
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Diabetes Management and Research
- Parathyroid Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Diabetes Treatment and Management
- Ion Transport and Channel Regulation
- Phagocytosis and Immune Regulation
- Vitamin C and Antioxidants Research
- Pharmacogenetics and Drug Metabolism
- Connective tissue disorders research
- Receptor Mechanisms and Signaling
- Lipoproteins and Cardiovascular Health
- Metabolism, Diabetes, and Cancer
- Cardiovascular Function and Risk Factors
- Angiogenesis and VEGF in Cancer
- Child Nutrition and Water Access
University of Massachusetts Amherst
2023
Joslin Diabetes Center
2020-2022
University of Virginia
2021
Harvard University
2020-2021
This study applies a large proteomics panel to search for new circulating biomarkers associated with progression kidney failure in individuals diabetic disease. Four independent cohorts encompassing 754 type 1 and 2 diabetes early late disease were followed ascertain failure. During ten years of follow-up, 227 progressed Using the SOMAscan platform, we measured baseline concentration 1129 proteins. In our previous publications, analyzed 334 these proteins that members specific candidate...
Circulating proteins associated with transforming growth factor-β (TGF-β) signaling are implicated in the development of diabetic kidney disease (DKD). It remains to be comprehensively examined which these involved pathogenesis DKD and its progression end-stage (ESKD) humans. Using SOMAscan proteomic platform, we measured concentrations 25 TGF-β family four different cohorts composed total 754 Caucasian or Pima Indian individuals type 1 2 diabetes. Of circulating proteins, identified...
Mechanisms underlying the pro gression of diabetic kidney disease to ESKD are not fully understood.
OBJECTIVE The role of fibrosis in early progressive renal decline type 2 diabetes is unknown. Circulating WFDC2 (WAP four-disulfide core domain protein 2) and matrix metalloproteinase 7 (MMP-7; Matrilysin) are postulated to be biomarkers fibrosis. This study examined an association circulating levels these proteins with decline. RESEARCH DESIGN AND METHODS Individuals enrolled the Joslin Kidney Study estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 were monitored for 6–12 years...
Global proteomics profiling identified FGF20, TNFSF12, and ANGPT1 as protective against progression of renal function decline in those with diabetes.
Rare variants in gene coding regions likely have a greater impact on disease-related phenotypes than common through disruption of their encoded protein. We searched for rare associated with onset ESKD individuals type 1 diabetes at advanced kidney disease stage.
Adiponectin, encoded by ADIPOQ, is an insulin-sensitizing, anti-inflammatory, and renoprotective adipokine that activates receptors with intrinsic ceramidase activity. We identified a family harboring 10-nucleotide deletion mutation in ADIPOQ cosegregates diabetes end-stage renal disease. This introduces frameshift exon 3, resulting premature termination codon disrupts translation of adiponectin's globular domain. Subjects the had dramatically reduced circulating adiponectin increased...
Abstract We recently identified a kidney risk inflammatory signature (KRIS), comprising 6 TNF receptors (including TNFR1 and TNFR2) 11 proteins. Elevated levels of these proteins in circulation were strongly associated with the development end-stage disease (ESKD) during 10-year follow-up. It has been hypothesized that elevated might reflect (be markers of) systemic exposure to TNFα. In this vitro study, we examined intracellular extracellular human umbilical vein endothelial cells (HUVECs)...
Background: miRNAs are short non-coding RNA molecules involved in gene regulation. Previously, we identified 17 plasma (8 risk and 9 protective miRNAs) associated with progression to ESKD diabetes (JASN 2021). Factors that influence the measurement of miRNA concentrations, thus could impact replication these findings, including extraction method, profiling source biofluid, have not been investigated. Methods: Plasma serum were obtained from patients who participated Joslin Kidney Study....
<b>OBJECTIVE</b>: The role of fibrosis in early progressive renal decline type 2 diabetes is unknown. Circulating WFDC2 (WAP four-disulfide core domain protein 2) and MMP-7 (Matrilysin) are postulated to be biomarkers fibrosis. This study examined an association circulating levels these proteins with decline. <p><b>RESEARCH DESIGN AND METHODS</b>: Individuals enrolled the Joslin Kidney Study eGFR ≥60 ml/min/1.73m<sup>2</sup> were followed for 6-12...
<b>OBJECTIVE</b>: The role of fibrosis in early progressive renal decline type 2 diabetes is unknown. Circulating WFDC2 (WAP four-disulfide core domain protein 2) and MMP-7 (Matrilysin) are postulated to be biomarkers fibrosis. This study examined an association circulating levels these proteins with decline. <p><b>RESEARCH DESIGN AND METHODS</b>: Individuals enrolled the Joslin Kidney Study eGFR ≥60 ml/min/1.73m<sup>2</sup> were followed for 6-12...