A5001791944- Chronic Kidney Disease and Diabetes
- MicroRNA in disease regulation
- Dialysis and Renal Disease Management
- Extracellular vesicles in disease
- Diabetes and associated disorders
- Renal Diseases and Glomerulopathies
- Diabetes Management and Research
- Birth, Development, and Health
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Advanced Glycation End Products research
- Parathyroid Disorders and Treatments
- Inflammasome and immune disorders
- Circular RNAs in diseases
- Adipose Tissue and Metabolism
- Obesity, Physical Activity, Diet
- Hormonal Regulation and Hypertension
- Axon Guidance and Neuronal Signaling
- Mesenchymal stem cell research
- Fibroblast Growth Factor Research
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Systemic Sclerosis and Related Diseases
Harvard University
2015-2024
Joslin Diabetes Center
2015-2024
Harvard University Press
2024
Indianapolis Zoo
2023
Haibara General Hospital
2022
University of Helsinki
2021
Helsinki University Hospital
2021
Nihon University
2021
University of Virginia
2021
Hamamatsu University School of Medicine
2010-2018
We investigated whether circulating TGF-β1–regulated miRNAs detectable in plasma are associated with the risk of rapid progression to end-stage renal disease (ESRD) a cohort proteinuric patients type 1 diabetes (T1D) and normal eGFR. Plasma specimens obtained at entry study were examined two prospective subgroups that followed for 7–20 years (rapid progressors nonprogressors), as well reference panel normoalbuminuric T1D patients. Of five this study, let-7c-5p miR-29a-3p significantly...
We investigated plasma microRNA (miRNA) profiles associated with variation of hyperglycemia, measured as hemoglobin A1c (HbA1c), in two panels patients type 1 diabetes (T1D). Using the HTG Molecular Diagnostics EdgeSeq platform, 2,083 miRNAs were from 71 included a screening panel. Quantitative real-time PCR was used to measure candidate 95 an independent replication found 10 replicated both and 4 high statistical significance. The strongest positive correlations HbA1c miR-125b-5p (rs =...
This study applies a large proteomics panel to search for new circulating biomarkers associated with progression kidney failure in individuals diabetic disease. Four independent cohorts encompassing 754 type 1 and 2 diabetes early late disease were followed ascertain failure. During ten years of follow-up, 227 progressed Using the SOMAscan platform, we measured baseline concentration 1129 proteins. In our previous publications, analyzed 334 these proteins that members specific candidate...
Circulating proteins associated with transforming growth factor-β (TGF-β) signaling are implicated in the development of diabetic kidney disease (DKD). It remains to be comprehensively examined which these involved pathogenesis DKD and its progression end-stage (ESKD) humans. Using SOMAscan proteomic platform, we measured concentrations 25 TGF-β family four different cohorts composed total 754 Caucasian or Pima Indian individuals type 1 2 diabetes. Of circulating proteins, identified...
Mechanisms underlying the pro gression of diabetic kidney disease to ESKD are not fully understood.
Variation in DNA methylation (DNAmet) white blood cells and other cells/tissues has been implicated the etiology of progressive diabetic kidney disease (DKD). However, specific mechanisms linking DNAmet variation with risk failure (KF) utility measuring cell personalized medicine are not clear. We measured 277 individuals type 1 diabetes DKD using Illumina EPIC arrays; 51% cohort developed KF during 7 to 20 years follow-up. Our epigenome-wide analysis identified at 17 CpGs...
OBJECTIVE The role of fibrosis in early progressive renal decline type 2 diabetes is unknown. Circulating WFDC2 (WAP four-disulfide core domain protein 2) and matrix metalloproteinase 7 (MMP-7; Matrilysin) are postulated to be biomarkers fibrosis. This study examined an association circulating levels these proteins with decline. RESEARCH DESIGN AND METHODS Individuals enrolled the Joslin Kidney Study estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 were monitored for 6–12 years...
Global proteomics profiling identified FGF20, TNFSF12, and ANGPT1 as protective against progression of renal function decline in those with diabetes.
To assess fat distribution in non-obese Japanese children and adolescents.130 (73 boys 57 girls) from Kikugawa, Hamamatsu were included. The visceral area (VFA) subcutaneous (SFA) measured by computed tomography (CT) calculated (in cm(2)). Subjects divided into three groups based on age: group A (6-10 years), B (11-15 C (16-20 years).Girls had more than (P<0.01). Boys an age-dependent increase fat, but girls did not. In (P<0.01).In children, there are significant differences amounts age sex....
Rare variants in gene coding regions likely have a greater impact on disease-related phenotypes than common through disruption of their encoded protein. We searched for rare associated with onset ESKD individuals type 1 diabetes at advanced kidney disease stage.
In Japan, waist circumference (WC) percentiles to screen for childhood metabolic syndrome (MetS) are unavailable. The objectives of this study were develop WC and WC-to-height ratio (WC/Ht) percentile curves by age sex Japanese children, test their utility in screening MetS children with obesity who otherwise healthy. WC/Ht developed using the LMS method summarizing growth standards, which monitors changing skewness (L), medians (M), coefficients variation (S) distributions. A representative...
Peroxisomal proliferator-activated receptors (PPARs) play an important role in the regulation of lipid metabolism. The aim this study was to investigate effects a maternal high-fat (HF) diet on serum concentration and PPAR gene expression liver adipose tissue early life rat offspring. Female Sprague-Dawley rats were fed either HF or control (CON) 6 weeks before mating throughout gestation lactation. Blood samplings male offspring carried out at birth weaning. Birth weights similar...
Our previous study identified 8 risk and 9 protective plasma miRNAs associated with progression to end-stage kidney disease (ESKD) in diabetes. This aimed elucidate preanalytical factors that influence the quantification of circulating miRNAs. Using EdgeSeq platform, which quantifies 2,002 plasma, including ESKD-associated miRNAs, we compared miRNA profiles whole versus RNA extracted from same specimens. Less than half were detected standard extraction plasma. Detection individual...
Many circulating proteins are associated with risk of ESKD, but their source and the biological pathways/disease processes they represent unclear. Using OLINK proteomics platform, concentrations 455 were measured in plasma specimens obtained at baseline from 399 individuals diabetes. Elevated 46 (P < 1 × 10-5) development ESKD (n = 143) during 7-15 years follow-up. Twenty these enriched apoptosis/TNF receptor signaling pathways. A subset 20 (5-7 proteins), summarized as an apoptosis score,...
Intrauterine growth restriction (IUGR) is associated with a substantially greater incidence of metabolic syndrome in adulthood. Animal studies have shown that IUGR offspring are hyperphagic during the early postnatal period and therefore exhibit obesity. The molecular mechanisms underlying food intake regulation gastrointestinal tract not been clarified IUGR. In present study, we utilized rat model by restricting mother (50% normal intake, ad libitum; FR group) from day 7 gestation until...
Glucocorticoid (GC) excess promotes adipose tissue accumulation, and 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) plays an important role in the local amplification of GC. Therefore, this study, we investigated effects carbenoxolone (CBX), 11β-HSD1 inhibitor, on morphological changes visceral fat, expression genes involved adipogenesis lipid metabolism high-fat (HF) diet-fed mice. Mice were fed a HF diet from 5 weeks age. At 10 age, mice received intraperitoneal injection CBX or...
The purpose of this study was to clarify the degree early postnatal growth by birthweight and detect predictive factors for pediatric obesity.Body mass index (BMI) obesity were examined in children fourth year elementary school second junior high school.Their BMI at birth three years age also examined.Based on birthweight, participants divided into groups: low (< 2500 g), middle (2500-3500 (> 3500 g).Furthermore, according obesity, they two obese (20% ≤) non-obese >).The change from (ΔBMI)...
Antithyroid drugs are widely used in the therapy of Graves' disease (GD), and methimazole (MMI) is preferred for treatment pediatric GD. The recommended initial dosage MMI 0.5-1.0 mg/kg/d GD, although there few studies on optimal children. We retrospectively compared efficacy different doses 35 children with Eight were excluded due to lack follow-up, etc. remaining 27 divided into a high-dose group (HD; MMI≥0.7 (0.85 ± 0.13) mg/kg/d, n=8) low-dose (LD; MMI<0.7 (0.51 0.12) n=19), we time...
Urinary myo-inositol (UMI) level is elevated in adult diabetic patients, and also increases after glucose loading. However, the relationship between UMI plasma levels children unknown. We aimed to assess whether a practical marker for intolerance or not.In Study 1 (328 schoolchildren), fasting postprandial were measured, with ΔUMI defined as difference levels. In 2, oral tolerance tests measurements conducted 18 suspected having diabetes.For 1, was observed [-0.65 (-3.9, 1.35) mg/g...