A5101475155- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Hepatitis B Virus Studies
- Acute Kidney Injury Research
- Traditional Chinese Medicine Studies
- Cell death mechanisms and regulation
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- Inflammatory mediators and NSAID effects
- Peroxisome Proliferator-Activated Receptors
- Iron Metabolism and Disorders
- Pediatric Urology and Nephrology Studies
- Renal and related cancers
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Urinary Tract Infections Management
- Lipid metabolism and disorders
- Erythrocyte Function and Pathophysiology
- Diabetes Treatment and Management
- Blood Pressure and Hypertension Studies
- Eicosanoids and Hypertension Pharmacology
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Cardiac Fibrosis and Remodeling
China Medical University
2013-2025
Griffith University
2024
China Pharmaceutical University
2022
Northeast Agricultural University
2021
Central South University
2020
Xiangya Hospital Central South University
2020
Sheng Jing Hospital
2010
Air Force General Hospital PLA
2008
Pediatric Nephrology of Alabama
2008
Shijiazhuang Great Wall Hospital
2007
Abstract Background The prevalence of lupus nephritis (LN) remains high despite various emerging monoclonal antibodies against with targeting systemic erythematosus (SLE). Renal fibrosis is the main feature late stage LN, and novel therapeutic agents are still needed. We previously reported that microRNA (miR)-150 increases in renal biopsies American LN patients miR-150 agonist promotes cultured kidney cells. Presently, we aim to verify whether locked nucleic acid (LNA)-anti-miR-150 can...
Hepatitis B virus X protein (HBx) is a multifunctional protein, and it activates multiple signal transduction pathways in types of cells regulates the process cell apoptosis. In present study, we mainly investigated correlation between HBx renal tubular epithelial apoptosis hepatitis virus-associated glomerulonephritis (HBVGN) possible signaling mechanism. Cell nephridial tissues patients with HBVGN were determined by TUNEL method. HBx, p-STAT3 STAT3 levels immunohistochemical assay,...
A prospective, multi-center, randomized controlled study was conducted to evaluate the efficacy and safety of a 24-week course low-dose leflunomide combined with prednisone in induction treatment proliferative lupus nephritis Chinese patients. Patients (n = 100) biopsy–proved were enrolled this study. They into two groups received either or cyclophosphamide conjunction for 24 weeks. Leflunomide given orally loading dose 40 mg/day 3 days followed by 20 mg/day. Intravenous administered monthly...
To evaluate the efficacy and safety of SHR4640, a highly selective urate transporter 1 inhibitor, in Chinese subjects with hyperuricaemia.This was randomized double-blind dose-ranging phase II study. Subjects whose serum uric acid (sUA) levels were ≥480 µmol/l gout, without gout but comorbidities, or ≥540 enrolled. randomly assigned (1:1:1:1:1) to receive once daily 2.5 mg, 5 10 mg 50 benzbromarone placebo, respectively. The primary end point proportion who achieved target sUA level ≤360 at...
Peroxisome proliferator-activated receptors (PPARs) are a nuclear receptor family of ligand-inducible transcription factors, which have three different isoforms: PPARα, δ and γ. It has been demonstrated that PPARα γ agonists renoprotective effects in proteinuric kidney diseases; however, the role PPARδ diseases remains unclear. Thus, we examined effect GW501516, agonist, protein-overload mouse nephropathy model identified its molecular mechanism. Mice fed with control diet or...
Abstract To simulate clinical features in human chronic kidney disease (CKD), SD rats were subjected to 5/6 nephrectomy this study. We found that periostin gene was upregulated the remnant kidneys using Agilent microarrays, and further explored its role via vivo vitro experiments. Intrarenal renin–angiotensin system (RAS) activated nephrectomized partly deactivated by injection of adenoviruses encoding short hairpin RNA against (sh‐ ). Renal fibrosis profibrotic transforming growth...
Abstract Background: Chronic kidney disease (CKD)-associated anemia (CKD-anemia) is associated with poor survival, and hemoglobin targets are often not achieved current therapies. Phase 3 trials have demonstrated the treatment efficacy of roxadustat for CKD-anemia. This phase four study aims to evaluate long-term (52-week) safety effectiveness in a broad real-world patient population CKD-anemia without dialysis China. Methods: 4 multicenter, open-label, prospective study, conducted from 24...
The aim of our study was to reveal the role CD44-Hyaluronic acid (HA) in homing and improving renal function systemically transplanted MSCs chronic failure.First, a remnant kidney model established rats expression HA determined using immunohistochemistry (IHC) western blotting. Next, chemotaxis assay flow cytometry, cell migration were performed vitro. Then, into rats, thus, sprague-Dawley (SD) randomly divided sham group, 5/6 nephrectomy (5/6 Nx) MSC group MSC/Anti-CD44 (n = 8 for all...
The present study was conducted to investigate the effects of probucol on progression diabetic nephropathy and underlying mechanism in type 2 db/db mice. Eight weeks mice were treated with regular diet or probucol-containing (1%) for 12 weeks. Non-diabetic db/m used as controls. We examined body weight, blood glucose, urinary albumin. At 20 weeks, experimental sacrificed their kidneys extracted analysis chemistry, kidney histology, oxidative stress marker, podocyte marker. As a result, 24 h...
Background It is unclear whether short‐term blood pressure variability associated with renal outcomes in patients chronic kidney disease. Methods and Results This study analyzed data from participants the C‐ STRIDE (Chinese Cohort Study of Chronic Kidney Disease) who had disease stages 1 to 4. Short‐term was measured by calculating weighted SD (w‐ ) systolic ( SBP ). Renal were defined as dialysis initiation and/or transplantation. Risk factors w‐ evaluated linear regression. Associations...
Ureteral obstruction leads to renal injury and progresses irreversible fibrosis, with tubular cell atrophy apoptosis. There is conflicting evidence concerning whether losartan (an angiotensin II type I receptor antagonist) mitigates interstitial fibrosis epithelial apoptosis following unilateral ureteral (UUO) in animal models. The aim of this study was investigate the effect mechanism on a rat model UUO. rats were subjected UUO by ligation treated dimethyl sulfoxide (control) or losartan....
Background/Aims: Hepatitis B virus (HBV)-associated glomerulonephritis (HBV-GN) is characterized by a reduced number of podocytes due to apoptosis and shedding from the basement membrane. However, pathological mechanism HBV-GN unclear. We previously showed that hepatitis X protein (HBx) promotes in tubular epithelial cells. In this study, we transfected with HBx examined effects on adhesion these Methods: Podocytes were pc-DNA3.1 (+)-HBx. One control group was not another empty plasmids....
Background/Aims: The hepatitis B virus X protein (HBx) contributes to HBV-induced injury of renal tubular cells and induces apoptosis via Fas/FasL up-regulation. However, the mechanism activation is unknown. Recent studies indicated that HBx induction in hepatic depends on activating MLK3-MKK7-JNKs signaling module, which then up-regulates FasL expression. In this study, we used NRK-52E transfected an expression vector examine role pathway HBx-induced cell injury. Methods: were with...
High glucose (HG) in peritoneal dialysates has been demonstrated to induce extracellular matrix (ECM) synthesis by mesothelial cells (PMCs) and contribute fibrosis during continuous ambulatory dialysis (CAPD). In the present study, we investigated effects of pioglitazone, a peroxisome proliferator‑activated receptor γ (PPARγ) agonist, on HG‑induced ECM accumulation underlying mechanism rat PMCs (RPMCs). cultured RPMCs, HG treatment increased expression fibronectin (FN), collagen I...
The epithelial–mesenchymal transition (EMT) of tubular epithelial cells to myofibroblast-like plays a substantial role in renal tubulointerstitial fibrosis, which is common pathological character end-stage disease (ESRD). Fibroblast growth factor-2 (FGF-2) triggers EMT and increases Bcl-2-associated athanogene 3 (BAG3) expression neural progenitor neuroblastoma cells. In addition, novel regulation has been ascribed BAG3 recently. These previous reports urged us study the potential...
<b><i>Aims:</i></b> The optimal time for mesenchymal stem cell (MSCs) transplantation remains an unresolved issue. We compared the effects of MSCs on a rat remnant kidney model. <b><i>Methods:</i></b> Male Sprague-Dawley rats were randomly divided and treated with corresponding reagent at 4, 8, 12 16 weeks, respectively. A model was established injected into rats. migration then assessed by using cell-tracking experiments. Renal function...