A5027130695- interferon and immune responses
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- Viral Infections and Vectors
- RNA regulation and disease
- Skin and Cellular Biology Research
- GaN-based semiconductor devices and materials
- Carbohydrate Chemistry and Synthesis
- Macrophage Migration Inhibitory Factor
- Galectins and Cancer Biology
- Silicon and Solar Cell Technologies
- Veterinary medicine and infectious diseases
- Cancer-related Molecular Pathways
- Luminescence Properties of Advanced Materials
- Autoimmune and Inflammatory Disorders Research
- Polysaccharides and Plant Cell Walls
- Solar Thermal and Photovoltaic Systems
- Bone Tissue Engineering Materials
- Plant Reproductive Biology
- 3D Printing in Biomedical Research
- Advanced MEMS and NEMS Technologies
- DNA Repair Mechanisms
- Microtubule and mitosis dynamics
Peking University
2002-2025
Science et Ingénierie des Matériaux et Procédés
2019-2022
Université Grenoble Alpes
2017-2022
Centre National de la Recherche Scientifique
2022
Sun Yat-sen University
2021-2022
Stomatology Hospital
2021-2022
Institut polytechnique de Grenoble
2022
Hospital of Stomatology, Sun Yat-sen University
2021
Scripps Research Institute
2009
University of Colorado Health
2002
We report here the identification and characterization of a protein, ERIS, an endoplasmic reticulum (ER) IFN stimulator, which is strong type I stimulator plays pivotal role in response to both non-self-cytosolic RNA dsDNA. ERIS (also known as STING or MITA) resided exclusively on ER membrane. The retention/retrieval sequence RIR was found be critical retain protein membrane maintain its integrity. dimerized innate immune challenges. Coumermycin-induced dimerization led fast induction,...
Irregular defects generated by trauma or surgery in orthopaedics practice were usually difficult to be fitted the preformed traditional bone graft substitute. Therefore, injectable hydrogels have attracted an increasing interest for repair because of their fittability and mini-invasivity. However, uncontrollable spreading mechanical failures during its manipulation remain a problem solved. Moreover, order achieve vascularized regeneration, alternatives osteogenic angiogenic growth factors...
RIG-I and MDA5 are cytoplasmic sensors that recognize different species of viral RNAs, leads to activation the transcription factors IRF3 NF-kappaB, which collaborate induce type I interferons. In this study, we identified REUL, a RING-finger protein, as specific RIG-I-interacting protein. REUL was associated with RIG-I, but not MDA5, through its PRY SPRY domains. Overexpression potently potentiated RIG-I-, MDA5-mediated downstream signalling antiviral activity. contrast, RING domain...
Viral infection leads to activation of the transcription factors interferon regulatory factor-3 and NF-kappaB, which collaborate induce type I IFNs. The RNA helicase proteins RIG-I MDA5 were recently identified as two cytoplasmic viral sensors that recognize different species RNAs produced during replication. In this study, we DAK, a functionally unknown dihydroacetone kinase, specific MDA5-interacting protein. DAK was associated with MDA5, but not RIG-I, under physiological conditions....
Inflammation is a homeostatic mechanism that limits the effects of infectious agents. Tumor necrosis factor (TNF) and interleukin (IL)-1 are two cytokines induce inflammation through activation transcription NF-kappaB. Various studies have suggested homologous structurally related adapter proteins TAB2 TAB3 play redundant roles in TNF- IL-1-mediated NF-kappaB pathways. Both contain CUE, coiled-coil, nuclear protein localization 4 zinc finger (NZF) domains. The NZF domains TAB2/3 critical for...
Stimulator of interferon genes (STING) is essential for innate immune pathway activation in response to pathogenic DNA. Proper STING signaling requires translocation and phosphorylation. Here, we show that dual serine/threonine tyrosine protein kinase (DSTYK) directly phosphorylates Ser366 at late endosomes promote the signaling. We find TBK1 promotes post-Golgi trafficking via its activity, thereby enabling interaction between DSTYK STING. also demonstrate can both phosphorylation...
Receptor-interacting protein (RIP) is a serine/threonine kinase that critically involved in tumor necrosis factor receptor-1 (TNF-R1)-induced NF-κB activation. In yeast two-hybrid screening for potential RIP-interacting proteins, we identified ZIN (zinc finger inhibiting NF-κB), novel specifically interacts with RIP. contains four RING-like zinc domains at the middle and proline-rich domain C terminus. Overexpression of inhibits RIP-, IKKβ-, TNF-, IL1-induced activation dose-dependent manner...
Toll-like receptor 3 (TLR3) plays an important role in antiviral responses through recognizing viral double-stranded RNA produced during infection and mediating induction of type I IFN. TRIF is a Toll/IL-1 (TIR) domain-containing adaptor protein that associated with TLR3 critically involved TLR3-mediated signaling. In yeast two-hybrid screens, we identified TNF receptor-associated factor (TRAF)1 as TRIF-interacting protein. The TRAF-C domain TRAF1 the TIR were responsible for their...
Receptor-interacting protein 2 (RIP2) is a member of the RIP kinase family that has been shown to be crucially involved in inflammation, innate and adaptive immune responses. The physiological pathological roles RIP2 are mediated through its involvement multiple NF-kappaB activation pathways, including those triggered by tumor necrosis factor (TNF), interleukin 1 (IL-1), Toll-like receptor (TLR2), TLR3, TLR4 Nod1. In this report, we identified LIM-domain-containing TRIP6 as RIP2-interacting...
Retinoic acid-inducible gene I (RIG-I) recognizes RNA virus-derived nucleic acids, which leads to the production of type interferon (IFN) in most cell types. Tight regulation RIG-I activity is important prevent ultra-immune responses. In this study, we identified an ARF-like (ARL) family member, ARL16, as a protein that interacts with RIG-I. Overexpression but not its homologous proteins ARL1 and ARF1, inhibited RIG-I-mediated downstream signaling antiviral activity. Knockdown endogenous...
Early clinical cracked tooth can be a perplexing disorder to diagnose and manage. One of the key problems for diagnosis is detection location surface crack. This paper proposes an image-based method micro-crack in simulated tooth. A homemade three-axis motion platform mounted with telecentric lens was built as image acquisition system observe tooth, which under compression magnitude masticatory force. By using digital correlation (DIC), deformation map crown calculated. Through analysis,...