A5085540199- RNA Research and Splicing
- Genetics, Aging, and Longevity in Model Organisms
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Gut microbiota and health
- RNA regulation and disease
- Diet and metabolism studies
- Muscle Physiology and Disorders
- Shoulder and Clavicle Injuries
- Dementia and Cognitive Impairment Research
- Folate and B Vitamins Research
- Growth Hormone and Insulin-like Growth Factors
- Bariatric Surgery and Outcomes
- Neuroscience of respiration and sleep
- MicroRNA in disease regulation
- Total Knee Arthroplasty Outcomes
- Dysphagia Assessment and Management
- Child and Adolescent Psychosocial and Emotional Development
- HER2/EGFR in Cancer Research
- Shoulder Injury and Treatment
- Voice and Speech Disorders
- Cancer Research and Treatments
- Metabolism, Diabetes, and Cancer
- GDF15 and Related Biomarkers
- Traditional Chinese Medicine Studies
Jiangsu T-mab BioPharma (China)
2025
Sichuan University
2008-2024
West China Hospital of Sichuan University
2008-2024
University of Science and Technology of China
2017-2024
Shanghai Sixth People's Hospital
2020-2024
Shanghai Jiao Tong University
2019-2024
Alibaba Group (China)
2024
Foshan Hospital of TCM
2019-2023
Guangzhou University of Chinese Medicine
2020-2023
Ningxia Medical University
2018-2023
Abstract Exercise and diet are treatments for nonalcoholic fatty liver disease (NAFLD) prediabetes, however, how exercise interventions impact gut microbiota in patients is incompletely understood. We previously reported a 8.6-month, four-arm (Aerobic exercise, n = 29; Diet, 28; Aerobic + No intervention, 29) randomized, singe blinded (for researchers), controlled intervention with NAFLD prediabetes to assess the effect of on primary outcomes fat content glucose metabolism. Here we report...
Highlights•Integrates diverse microbiome datasets within the same analytical framework•Uncovers stable relationships among gut bacteria across interventions and disease states•Reveals a core structure of two competing guilds populations health status•Offers stably interacting microbial as novel targets for modulationSummaryThe microbiota is crucial human health, functioning complex adaptive system akin to vital organ. To identify health-relevant microbes, we followed systems biology tenet...
Kaposiform hemangioendothelioma (KHE) is an aggressive disease with high morbidity and mortality. The aim of this study was to retrospectively evaluate the efficacy safety sirolimus for treatment progressive KHE. A multicenter, retrospective cohort conducted in patients KHE treated sirolimus. total 52 were analyzed. Thirty-seven (71%) exhibited Kasabach-Merritt phenomenon (KMP) significantly younger than without KMP [95% confidence interval (CI), 14.39-41.61; p < 0.001]. Patients all alone,...
RNAi-elicited gene silencing is heritable and can persist for multiple generations after its initial induction in C. elegans. However, the mechanism by which parental-acquired trait-specific information from RNAi inherited progenies not fully understood. Here, we identified a cytoplasmic Argonaute protein, WAGO-4, necessary inheritance of RNAi. WAGO-4 exhibits asymmetrical translocation to germline during early embryogenesis, accumulates at perinuclear foci germline, required exogenous...
Objective Gut microbial dysbiosis is associated with high heterogeneity of polycystic ovary syndrome (PCOS); however, studies about gut microbiota targeted clinical intervention in PCOS are limited. Our study aimed to evaluate the effects high-fiber diet or combined acarbose on phenotypes PCOS, focusing possible influence this process. Methods Twenty-five patients were recruited and randomly divided into two groups, W group (n = 14) received WTP (a composed whole grains, traditional Chinese...
The nucleolus is the most prominent membraneless organelle within nucleus. How nucleolar structure regulated poorly understood. Here, we identified two types of nucleoli in C. elegans. Type I are spherical and do not have visible vacuoles (NoVs), rRNA transcription processing factors evenly distributed throughout nucleolus. II contain vacuoles, exclusively accumulate periphery rim. NoV contains nucleoplasmic proteins capable exchanging contents with nucleoplasm. high-order dynamically...
Eukaryotic cells express a wide variety of endogenous small regulatory RNAs that function in the nucleus. We previously found erroneous rRNAs induce generation antisense ribosomal siRNAs (risiRNAs) which silence expression via nuclear RNAi defective (Nrde) pathway. To further understand biological roles and mechanisms this class RNAs, we conducted forward genetic screening to identify factors involved risiRNA Caenorhabditis elegans. risiRNAs accumulated RNA exosome mutants. directed...
The gut microbiota of autism spectrum disorder (ASD) children differs from that without ASD. maternal impacts offspring microbiota. However, the relationship between development ASD and bacteria shared their mothers remains elusive. Our study recruited 76 with 47 age- gender-matched typical (TD), as well both groups, investigated using amplicon sequence variants (ASVs). was altered compared TD, while no significant alterations were found in mothers. We established 30 bacterial coabundance...
The alteration of gut microbiota structure plays a pivotal role in the pathogenesis abnormal glycometabolism. However, microbiome features identified patient groups stratified solely based on glucose levels remain controversial among different studies. In this study, we 258 participants (discovery cohort) into three clusters according to an unsupervised method 16 clinical parameters involving blood glucose, insulin, and lipid. We found 67 cluster-specific (i.e., amplicon sequence variants...
Abstract Bulimia, which means a person has episodes of eating very large amount food (bingeing) during the feels loss control over their eating, is most primitive reason for being overweight and obese. The extended literature indicated that childhood emotional abuse close relationship with adverse mood states, bulimia, obesity. To comprehensively understand potential links among these factors, we evaluated multiple mediation model in anxiety/depression bulimia were mediators between body...
Abstract Background: EGFR and HER3, both belong to the family, are widely overexpressed in human malignancies, rendering them promising targets for cancer treatment. Cancer is a heterogeneous disease. Inter- intratumor heterogeneity believed be major factor contributing recurrence, metastasis resistance current socs. To address these therapeutic challenges, we generated JSKN021, dual payload ADC targeting EGFR/HER3. Both payloads, novel DNA topoisomerase I inhibitor (T01, Alphatecan) MMAE,...
Impulsiveness is a stable personal characteristic that contributes to obesity and may interact with it. Specifically, caused by unrestrained impulse eating not consciously controlled leads hormonal imbalance also can impair control. However, the mechanism of this relationship unclear. In our study, 35 obese individuals (body mass index, BMI > 28) were recruited matched 31 healthy controls (BMI < 24) in age education level. All participants underwent resting-state fMRI completed Barratt...
Temperature greatly affects numerous biological processes in all organisms. How multicellular organisms respond to and are impacted by hypothermic stress remains elusive. Here, we found that cold-warm stimuli induced depletion of the RNA exosome complex nucleoli but enriched it nucleoplasm. To further understand function mechanism stimuli, conducted forward genetic screening identified ZTF-7, which is required for from upon transient exposure C . elegans ZTF-7 a putative ortholog human...
Summary Paragraph Over eons of co-evolution, the gut microbiota has become an essential organ for humans 1,2 . However, it is unclear what core members and their ecological organization ensures stable provision this organ’s health-relevant functions to host. With high quality metagenome-assembled genomes as network nodes, here we identified two competing guilds 3 most stably highly connected bacteria that together correlate with a wide range host health conditions. Genomes in these kept...
BACKGROUND:The relationship between thyroid hormones and body anthropometric measures in type 2 diabetes mellitus (T2DM) patients with normal function is unclear. The purpose of this study was to evaluate the association composition euthyroid T2DM men women. MATERIAL AND METHODS:This a cross-sectional that included 561 patients. Fasting venous blood collected test laboratory indexes. Bioelectric impedance analysis (BIA) used measure composition. Propensity score matching (PSM) enroll similar...
Alzheimer’s disease (AD) is a complex, and multifactorial neurodegenerative disease. Previous studies have revealed that oxidative stress, synaptic toxicity, autophagy, neuroinflammation play crucial roles in the progress of AD, however, its pathogenesis still unclear. Recent researches indicated ferroptosis, an iron-dependent programmed cell death, might be involved AD. Therefore, we aim to screen correlative ferroptosis-related genes (FRGs) AD clarify insights into diagnostic value....
Background: Febuxostat and allopurinol are the most commonly used uric acid-lowering medications, their safety is of great concern, especially cardiovascular adverse reactions associated with febuxostat. We propose to study toxicity febuxostat using FDA Adverse Event Reporting System (FAERS) database. Methods: A total 64 quarters FAERS data were downloaded from 2004 2019. Febuxostat- allopurinol-related events extracted after cleaning. Signal detection was conducted by reporting odds ratio...
Abstract Rearranged chromosomes have been applied to construct genetic balancers manipulate essential genes in C. elegans. Although much effort has put into constructing balancer chromosomes, approximately 6% (map units) of the elegans genome not covered, and this area lies mostly pairing centers (PCs). Here, we developed a method for conditional chromosomal engineering through combinatorial use CRISPR/Cas9 Cre/LoxP technologies. Functional DNA fragments containing LoxP sequences were...