A5063651798- Sulfur Compounds in Biology
- Industrial Gas Emission Control
- Polyamine Metabolism and Applications
- Neuroscience of respiration and sleep
- Molecular Sensors and Ion Detection
- Mast cells and histamine
- Air Quality and Health Impacts
- Mining and Gasification Technologies
- Amino Acid Enzymes and Metabolism
- Adsorption and Cooling Systems
- Food Waste Reduction and Sustainability
- Obstructive Sleep Apnea Research
- Odor and Emission Control Technologies
- Advanced Glycation End Products research
- Folate and B Vitamins Research
- Geotechnical and Geomechanical Engineering
The University of Tokyo
2015-2018
Tohoku University
2003
Abstract Hydrogen sulfide (H 2 S) and hydrogen polysulfides S n , >1) are endogenous regulators of many physiological processes. In order to better understand the symbiotic relationship cellular cross‐talk between H it is highly desirable develop single fluorescent probes which enable dual‐channel discrimination . Herein, we report rational design, synthesis, evaluation first dual‐detection probe DDP‐1 that can visualize with different fluorescence signals. The showed high selectivity...
Hydrogen sulfide (H2S) exerts synergistic effects with another gaseous signaling molecule nitric oxide (NO) on ion channels and vasculature. However, the mechanism of synergy is not well understood. Here, we show that interaction between H2S NO generates polysulfides (H2Sn), which activate transient receptor potential ankyrin 1 (TRPA1) channels. High performance liquid chromatography tandem mass spectrometry analysis, along imaging intracellular Ca2+ H2Sn, showed H2Sn their were abolished by...
Abstract Very recent studies indicate that sulfur atoms with oxidation state 0 or −1, called sulfane sulfurs, are the actual mediators of some physiological processes previously considered to be regulated by hydrogen sulfide (H 2 S). 3-Mercaptopyruvate sulfurtransferase (3MST), one three H S-producing enzymes, was also recently shown produce S n ). Here, we report discovery several potent 3MST inhibitors means high-throughput screening (HTS) a large chemical library (174,118 compounds) our...
We developed a reversible fluorescent probe for sulfane sulfur. This enabled us to monitor concentration changes of
Abstract Hydrogen sulfide (H 2 S) and hydrogen polysulfides S n , >1) are endogenous regulators of many physiological processes. In order to better understand the symbiotic relationship cellular cross‐talk between H it is highly desirable develop single fluorescent probes which enable dual‐channel discrimination . Herein, we report rational design, synthesis, evaluation first dual‐detection probe DDP‐1 that can visualize with different fluorescence signals. The showed high selectivity...