A5043298289- Global Maternal and Child Health
- SARS-CoV-2 and COVID-19 Research
- Healthcare Systems and Reforms
- Virus-based gene therapy research
- Child Nutrition and Water Access
- Healthcare Systems and Practices
- HIV/AIDS Impact and Responses
- Global Health Care Issues
- Vaccine Coverage and Hesitancy
- HIV/AIDS Research and Interventions
- Ureteral procedures and complications
- Hemoglobinopathies and Related Disorders
- Disaster Response and Management
- Genital Health and Disease
- Animal Virus Infections Studies
- Pharmaceutical studies and practices
- Global Cancer Incidence and Screening
- Hepatitis B Virus Studies
- Viral Infections and Outbreaks Research
- Immunotherapy and Immune Responses
- Urological Disorders and Treatments
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- HIV/AIDS drug development and treatment
- COVID-19 epidemiological studies
Université Alioune Diop de Bambey
2016-2024
Harvard University
2021-2024
Harvard Stem Cell Institute
2021-2024
Université de Thiès
2018-2024
Smith-Kettlewell Eye Research Institute
2021-2024
Massachusetts Eye and Ear Infirmary
2021-2024
Broad Institute
2021-2024
Cheikh Anta Diop University
2020-2023
Innovative Genomics Institute
2021-2022
Clinique Saint-Joseph
2020
Introduction : Mutual health insurance constitutes a micro-insurance system which facilitates access to care by avoiding direct payment. They represent one of the pillars our Universal Health Coverage. After years existence and despite political commitment, community support for mutual remains low until now. The objective work was study factors linked membership companies in Thiès region propose solutions. Methodology cross-sectional, descriptive analytical. It carried out among sample...
The SARS-CoV-2 pandemic has affected more than 185 million people worldwide resulting in over 4 deaths. To contain the pandemic, there is a continued need for safe vaccines that provide durable protection at low and scalable doses can be deployed easily. Here, AAVCOVID-1, an adeno-associated viral (AAV), spike-gene-based vaccine candidate demonstrates potent immunogenicity mouse non-human primates following single injection confers complete from challenge macaques. Peak neutralizing antibody...
Gene therapy is emerging as a modality in 21st-century medicine. Adeno-associated viral (AAV) gene transfer leading technology to achieve efficient and durable expression of therapeutic transgene. However, the structural complexity capsid has constrained efforts engineer particle toward improved clinical safety efficacy. Here, we generate curated library barcoded AAVs with mutations across variety functionally relevant motifs. We then screen this vitro vivo mice nonhuman primates, enabling...
Journal Article Human T‐cell leukaemia/lymphoma virus type 1‐associated infective dermatitis in Africa: a report of five cases from Senegal Get access A. Mahé, Mahé Institut d'Hygiène Sociale, Dakar, *Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département d'Ecosytème Epidémiologie Maladies Infectieuses, Bâtiment Lwoff, Pasteur, Paris, France †Department Infectious Diseases, CHU Fann, ‡Institut Pasteur de §Department Hematology, Hôpital Necker, BP 16705, Dakar‐Fann,...
The COVID-19 pandemic continues to have devastating consequences on health and economy, even after the approval of safe effective vaccines. Waning immunity, emergence variants concern, breakthrough infections, lack global vaccine access acceptance perpetuate epidemic. Here, we demonstrate that a single injection an adenoassociated virus (AAV)-based elicits at least 17-month-long neutralizing antibody responses in non-human primates levels were previously shown protect from viral challenge....
Summary The SARS-CoV-2 pandemic has affected more than 70 million people worldwide and resulted in over 1.5 deaths. A broad deployment of effective immunization campaigns to achieve population immunity at global scale will depend on the biological logistical attributes vaccine. Here, two adeno-associated viral (AAV)-based vaccine candidates demonstrate potent immunogenicity mouse nonhuman primates following a single injection. Peak neutralizing antibody titers remain sustained 5 months are...
Objectives. The objectives of our study are: i) estimate the survival time cases sickle cell diseases monitored at Albert Royer National Children's Hospital Center, Dakar, Senegal from 1990 to 2010, ii) identify prognostic factors related deaths. Methods. Comprehensive and retrospective analysis death 1650 patients with disease followed in management unit Center January 1<sup>st</sup>, 1991 December 31, 2010 (20 years). 17 variables were studied: gender, ethnicity, geographical origin, age...
The SARS-CoV-2 pandemic has had a disastrous impact on global health. Although some vaccine candidates have been effective in combating SARS-CoV-2, logistical, economical, and sociological aspects still limit access globally. Recently, we reported two room-temperature stable AAV-based COVID-19 vaccines that induced potent protective immunogenicity following single injection murine primate models. Obesity old age are associated with increased mortality COVID-19, as well reduced efficacy of...
Introduction: Over the past years, efforts have been made to expand access antiretroviral combinations (cART) in low-income countries. However, major concerns are noted with drug resistance emergence, as treatment failure result and need introduce a second line treatment, more expensive difficult implement. The objective was study incidence of switch line, reasons for risk factors using cohort people living HIV an Ambulatory Treatment Center Dakar. Methodology: This under cART from January...
Introduction: Abscesses of the liver are due to an infection bacterial, parasitic or fungal origin. Through amoebiological imaging and serology, their diagnosis was facilitated. The aim this study determine epidemiological, clinical, diagnostic evolutionary aspects these abscesses at Department Infectious Tropical Diseases in Fann Teaching University Hospital. Patients Methods: This a retrospective descriptive study, based on records patients hospitalized for abscess over period 8 years,...
the World Health Organization (WHO) recommends immediate and exclusive breastfeeding in order to reduce malnutrition neonatal mortality. The purpose of this study was determine prevalence (EBF) identify its associated factors among mothers children aged 6 12 months Kaolack.we conducted a cross-sectional descriptive analytical study. from July 8th, 2020 February 2021. Multivariate analysis performed using logistic regression model. target population consisted residing city Kaolack met during...
Background: Urethrocystoscopy is a method of endoscopic exploration that allows direct visualization the urethra and bladder for diagnosis or treatment diseases lower urinary tract. Purpose: To determine epidemiological profile patients who underwent urethrocystoscopy to present indications results this examination. Patients Methods: This retrospective, descriptive study all outpatient in Urology Andrology department Grand Mbour hospital. The data patients, indications, additional procedures...
Introduction: Rabies is a serious disease, as it always fatal, but can be prevented by sero-vaccination. It neglected tropical disease endemic in Asia and Africa. The aim of this study was to assess knowledge, attitudes practices regarding rabies determine the factors associated with them among people aged 18 over commune Niakhène. Methods: This cross-sectional, descriptive analytical survey subjects living A sample 300 individuals drawn from two-stage cluster stratified age sex. Bivariate...
Introduction: Breast cancer is second only to cervical in Senegal. It has a high mortality rate because of its late diagnosis and the inadequacy availability treatment. In countries with limited resources, breast self-examination still means early cancer. The aim study was assess knowledge, attitudes practice BSE commune Mbour. Methods: This descriptive analytical cross-sectional that took place from 01 30 July 2022 population consisted women aged 35 65 years who had been living area for...
Introduction The main objective of any healthcare establishment must be to ensure the quality patient care and customer satisfaction. It is necessary regularly assess aim this study was level satisfaction customers aged over 18 years attending emergency department health center. Methodology This a descriptive analytical cross-sectional patients over, who attended Samu Municipal between 02 30 May 2023. index determined using adapted 2009 SAPHORA-MCO questionnaire Likert scale. Results A total...
PARVAX is a genetic vaccine platform based on an adeno-associated vector that has demonstrated to elicit potent, durable, and protective immunity in nonhuman primates (NHPs) after single dose. Here, we assessed immunogenicity following prime-boost regimen against SARS-CoV-2. In mice, low-dose prime followed by higher-dose boost elicited potent neutralizing antibody responses distinct cross-reactivity profiles, depending the antigen used booster vaccine. However, anti-vector developed mice...
Introduction: In Senegal, previous studies showed a prevalence of smoking among health professionals between 11.6 and 12.8%. The general objective was to study in public hospitals the department Dakar. This cross-sectional with descriptive analytical aim, data collection phase which took place from October 11 November 23, 2021. population consisted medical paramedical staff. We collected 262 cases, i.e. non-participation rate 12.67%. Results: average age workers surveyed 28.19 %. There were...
Introduction: The objective is to study the consequences of COVID-19 on service provision at Serigne Mbacke Madina health center in Darou Khoudous Touba district. Materials and methods: To achieve this objective, a retrospective, descriptive was conducted from July 2021 December 2021. Results: Over period 2016-2020, age group 50-59 years 60 over rarely attended structure. This low attendance structure further accentuated 2020. According consultation by service: We note that General Medicine,...
Introduction : Au Sénégal, la mutualité a bénéficié d’un soutien politique considérable des autorités du pays qui ont défini Couverture Maladie Universelle (CMU) comme une priorité. L’objectif général de notre étude était d’évaluer viabilité mutuelles santé communautaires District Sanitaire d’Oussouye en 2018. Matériel et méthode Dans cette transversale descriptive à visée évaluative, mixte avait été utilisée. La évaluée dans ses dimensions institutionnelle, technique, fonctionnelle...
The purpose of this article is to identify, the factors that would explain adherence and use MS make recommendations for actions encourage population adhere more at in Ziguinchor region Senegal.The sample was concerned by 392 patients selected quota method hospitals region. data were processed analyzed sphinx stata software through logistic regression method.The study area were: perception, presence an elderly person household, confidence MS, household size pyramid medical institution.
Introduction: In resource-limited countries, the number of available antiretroviral (ARV) drugs is relatively limited. Hence, caregivers face some caution and constraints in changes ARV treatment (ART) people living with HIV (PLHIV). Our objective was to calculate incidence, describe main causes identify predictive factors first change Senegal. Methods: We conducted a retrospective cohort study on 331 infected patients who initiated ART 2009- 2011 followed until March 2012. The incidence...