A5013323902- Mycotoxins in Agriculture and Food
- Immune Response and Inflammation
- Selenium in Biological Systems
- Curcumin's Biomedical Applications
- Genomics, phytochemicals, and oxidative stress
- Carcinogens and Genotoxicity Assessment
- Bacterial Infections and Vaccines
- RNA and protein synthesis mechanisms
- Natural Antidiabetic Agents Studies
- Insect and Pesticide Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Research and Treatments
- Microbial Community Ecology and Physiology
- Cancer-related cognitive impairment studies
- Occupational and environmental lung diseases
- Environmental Toxicology and Ecotoxicology
- Pediatric health and respiratory diseases
- Probiotics and Fermented Foods
- Advanced Glycation End Products research
- Plant pathogens and resistance mechanisms
- Chronic Myeloid Leukemia Treatments
- Gut microbiota and health
- Mast cells and histamine
- Chemotherapy-induced cardiotoxicity and mitigation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University of Naples Federico II
2020-2025
Temple University
2024
Ochratoxin A (OTA) is a powerful mycotoxin found in various foods and feedstuff, responsible for subchronic chronic toxicity, such as nephrotoxicity, hepatotoxicity, teratogenicity, immunotoxicity to both humans several animal species. The severity of the liver damage caused depends on dose duration exposure. Several studies have suggested that oxidative stress might contribute increasing hepatotoxicity OTA, antioxidants, including curcumin (CURC), been tested counteract toxic hepatic action...
Aflatoxin B1 (AFB1) causes hepatotoxicity, immunotoxicity, and kidney damage, it is included in group I of human carcinogens. The European Commission has established maximum limits AFB1 feed, ranging from 5 to 20 μg/kg. Chicken moderately sensitive AFB1, which results reduced growth performance economic losses. Oxidative stress triggered by plays a crucial role damage the antioxidant activity Curcumin (CURC) could help preventing such adverse effect. Twenty-days-old broilers were treated for...
Ochratoxin A (OTA) is a powerful nephrotoxin and the severity of its damage to kidneys depends on both dose duration exposure. According scientific data currently available, mechanism action still not completely clarified, but it supposed that oxidative stress responsible for OTA-induced nephrotoxicity. Bioactive compound use has emerged as potential approach reduce chronic renal failure. Therefore, curcumin (CURC), due therapeutic effects, been chosen our study toxic effects induced by OTA....
Ochratoxin A (OTA) is a fungal toxin of critical concern for food safety both human health and several animal species, also representing cancer threat to humans. Curcumin (CURC) natural polyphenol that has anti-apoptotic, anti-inflammatory, antioxidant effects. The aim this study was investigate the cytoprotective effect CURC against OTA-induced nephrotoxicity hepatotoxicity through nitrosative stress, pro-inflammatory cytokines, deoxyribonucleic acid (DNA) damage. Sprague Dawley rats were...
Polaribacter sp. SM1127, a cold‐adapted marine Gram‐negative bacterium isolated from Laminaria in Arctic waters, plays crucial role nutrient cycling and biopolymer degradation cold environments. Additionally, its exopolysaccharide (EPS) exhibits promising biotechnological potential, including antioxidant wound‐healing properties. This study focuses on the isolation characterization of lipid A, glycolipid component SM1127 lipopolysaccharide (LPS), by bypassing full LPS extraction working...
Mesothelioma is an aggressive cancer with limited treatment options. therapy often involves a multimodal approach including surgery, radiotherapy and chemotherapy. However, the prognosis for patients remains poor. Difficult diagnosis, late symptoms when tumor in advanced stage onset of chemotherapy resistance make mesothelioma difficult to treat. For this reason, it essential discover new pharmacological approaches. Capsaicin (CAPS) active compound chili peppers. Based on CAPS's anticancer...
Abstract Veillonella parvula , prototypical member of the oral and gut microbiota, is at times commensal yet also potentially pathogenic. The definition molecular basis tailoring this contrasting behavior key for broadening our understanding microbiota‐driven pathogenic and/or tolerogenic mechanisms that take place within body. In study, we focused on chemistry main constituent outer membrane V. lipopolysaccharide (LPS). LPS molecules indeed elicit pro‐inflammatory immunomodulatory responses...
Diabetic nephropathy (DN) is the primary cause of end-stage renal disease, worldwide, and oxidative stress has been recognized as a key factor in pathogenesis progression DN. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase most important contribution to reactive oxygen species generation during development Bioactive compound use emerged potential approach reduce chronic failure. Therefore, red orange lemon extract (RLE) rich anthocyanins was chosen our study, toxic effects DN...
Chronic myeloid leukemia (CML) is a myeloproliferative disease that activates multiple signaling pathways, causing cells to produce higher levels of reactive oxygen species (ROS). Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are major generator ROS in leukemia, and marine natural products have shown promising activities for the treatment hematopoietic malignancies. In present study, we investigated effect microalga Skeletonema marinoi (S.M.), ubiquitous diatom forms...
Aflatoxin B1 (AFB1), the mainly Aspergillus fungi derived mycotoxin, is well known for its carcinogenic effects on liver, and frequently occurs in food supplies, leading to fatal consequences both farm animals humans. Poultry, one of most important segments agro-industry, has been demonstrated be extremely sensitive AFB1 intake, which results chickens' low performance, decreased quality eggs meat a negative economic feedback. Oxidative stress caused by plays crucial role kidney damage...
Ochratoxin A (OTA) is a mycotoxin which represents an emerging problem for both animal and human health, due to its high presence in feed foods. Exposure OTA associated with oxidative stress-induced nephrotoxicity. Therefore, the identification of new antioxidant or adsorbent substances protective action constitutes one main challenges reduce negative effects induced by mycotoxins. For this purpose, we investigated effect two innovative additives, bio-organoclay (CHS) mixture tri-octahedral...
Abstract Veillonella parvula , prototypical member of the oral and gut microbiota, is at times commensal yet also potentially pathogenic. The definition molecular basis tailoring this contrasting behavior key for broadening our understanding microbiota‐driven pathogenic and/or tolerogenic mechanisms that take place within body. In study, we focused on chemistry main constituent outer membrane V. lipopolysaccharide (LPS). LPS molecules indeed elicit pro‐inflammatory immunomodulatory responses...
Gram-negative bacteria living in marine waters have evolved peculiar adaptation strategies to deal with the numerous stress conditions that characterize aquatic environments. Among multiple mechanisms for efficient adaptation, these typically exhibit chemical modifications structure of lipopolysaccharide (LPS), which is a fundamental component their outer membrane. In particular, glycolipid anchor membrane LPSs, i.e. lipid A, frequently shows unusual structures, are reflected equally...
Abstract Background and Aims Type 2 diabetes mellitus is a pathological chronical condition that induce rearrangement in carbohydrate metabolism (Kaneto H et al. Antioxid Redox Signal. 2007). Even if the mechanism of DN not yet clear, NADPH oxidase (NOX) has been demonstrated to be involved kidney ROS (Reactive Oxygen Species) generation during diabetic state (Palicz A. J Biol Chem. 2001). Therefore, NOX-4, whose p22-phox subunit have shown pivotal role development, considered potential...