A5082216849- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Bioinformatics and Genomic Networks
- Bone Tissue Engineering Materials
- CRISPR and Genetic Engineering
- Neuroscience and Neuropharmacology Research
- Biomedical Ethics and Regulation
- Dental Implant Techniques and Outcomes
- Tissue Engineering and Regenerative Medicine
- Receptor Mechanisms and Signaling
- Graphene and Nanomaterials Applications
- Ion channel regulation and function
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- Periodontal Regeneration and Treatments
- Conducting polymers and applications
- Hearing, Cochlea, Tinnitus, Genetics
- Schizophrenia research and treatment
- Planarian Biology and Electrostimulation
- Corneal surgery and disorders
- Facial Trauma and Fracture Management
- Genetics, Bioinformatics, and Biomedical Research
- Congenital heart defects research
- Neural dynamics and brain function
Chris O’Brien Lifehouse
2021-2025
The University of Sydney
2022-2025
University of Wollongong
2016-2025
Queensland University of Technology
2025
ARC Centre of Excellence for Electromaterials Science
2015-2024
Illawarra Health and Medical Research Institute
2015-2024
Ludwig-Maximilians-Universität München
2022-2024
St Vincent's Hospital
2010-2021
The University of Melbourne
2012-2021
Australian Research Council
2017
GRM3 , a metabotropic glutamate receptor-modulating synaptic glutamate, is promising schizophrenia candidate gene. In family-based association study, common haplotype was strongly associated with ( P = 0.0001). Within this haplotype, the A allele of single-nucleotide polymorphism (SNP) 4 (hCV11245618) in intron 2 slightly overtransmitted to probands 0.02). We studied effects SNP on neurobiological traits related risk for and neurotransmission. The SNP4 poorer performance several cognitive...
Direct‐write printing of stem cells within biomaterials presents an opportunity to engineer tissue for in vitro modeling and regenerative medicine. Here, a first example constructing neural by human that are differentiated situ functional neurons supporting neuroglia is reported. The biomaterial incorporates novel clinically relevant polysaccharide‐based bioink comprising alginate, carboxymethyl‐chitosan, agarose. printed rapidly gels stable cross‐linking form porous 3D scaffold...
The ability to create 3D tissues from induced pluripotent stem cells (iPSCs) is poised revolutionize cell research and regenerative medicine, including individualized, patient‐specific cell‐based treatments. There are, however, few examples of tissue engineering using iPSCs. Their culture differentiation predominantly planar for monolayer support or induction self‐organizing embryoids (EBs) organoids. Bioprinting iPSCs with advanced biomaterials promises augment efforts develop tissues,...
Human embryonic stem (hES) cells originate during an period of active epigenetic remodeling. DNA methylation patterns are likely to be critical for their self-renewal and pluripotence. We compared the status 1536 CpG sites (from 371 genes) in 14 independently isolated hES cell lines with five other types: 24 cancer lines, four adult populations, lymphoblastoid normal human tissues, embryonal carcinoma line. found that profile clearly distinguished from all types. A subset 49 40 genes...
OBJECTIVE: Aberrant cholinergic inputs and synaptic neurotransmission in the prefrontal cortex induce cognitive impairment, which is a central feature of schizophrenia. Postsynaptic excitatory muscarinic M1 M4 receptors are major cholinoceptive targets hence may be involved pathology and/or pharmacotherapeutics METHOD: Using quantitative autoradiography, authors analyzed binding M1/M4 receptor selective antagonist [3H]pirenzepine (Brodmann's areas 8, 9, 10, 46) from schizophrenia patients...
The development and maintenance of spiral ganglion neurons (SGNs) appears to be supported by both neural activity neurotrophins. Removal this support leads their gradual degeneration. Here, we examined whether the exogenous delivery neurotrophin brain-derived neurotrophic factor (BDNF) in concert with electrical stimulation (ES) provides a greater protective effect than BDNF alone vivo. left cochlea profoundly deafened guinea pigs was implanted an electrode array drug-delivery system. or...
Conductive polymers (CPs) are organic materials that hold great promise for biomedicine. Potential applications include in vitro or implantable electrodes excitable cell recording and stimulation conductive scaffolds support tissue engineering. In this study, we demonstrate the utility of electroactive CP polypyrrole (PPy) containing anionic dopant dodecylbenzenesulfonate (DBS) to differentiate novel clinically relevant human neural stem cells (hNSCs). Electrical PPy(DBS) induced hNSCs...
Abstract Electricity is important in the physiology and development of human tissues such as embryonic fetal development, tissue regeneration for wound healing. Accordingly, electrical stimulation (ES) increasingly being applied to influence cell behavior function a biomimetic approach vitro culture engineering. Here, application conductive polymer (CP) poly(3,4‐ethylenedioxythiophene)‐polystyrenesulfonate (PEDOT:PSS) pillars described, direct‐write printed an array format, 3D ES maturing...
Osseointegration is a crucial property of biomaterials used for bone defect repair. While titanium the gold standard in craniofacial surgeries, various polymeric are being explored as alternatives. However, materials can be bioinert, hindering integration with surrounding tissues. In this investigation, plasma ion immersion implantation (PIII)-treated polyether ether ketone (PEEK) and (PEK) implants were assessed sheep maxilla mandible model. Defects filled PIII-treated PEEK PEK implants,...
Spiral ganglion neurons (SGNs), the primary afferent of cochlea, degenerate following a sensorineural hearing loss (SNHL) due to lack trophic support normally received from hair cells. Cell transplantation is emerging as potential strategy for inner ear rehabilitation, injected cells may be able replace damaged SGNs in deafened cochlea. An increase number surviving result improved efficacy cochlear implants (CIs). We examined survival partially differentiated mouse embryonic stem (MESCs),...
Biocompatible conductive tough hydrogels represent a new class of advanced materials combining the properties and biocompatible conductors. Here, simple method, to achieve self-assembled elastomeric composite structure that is biocompatible, conductive, with high flexibility, reported. The hydrogel comprises polyether-based liner polyurethane (PU), poly(3,4-ethylenedioxythiophene) (PEDOT) doped poly(4-styrenesulfonate) (PSS), liquid crystal graphene oxide (LCGO). hybrid (PUHC) containing...
Tissue engineering, based on a combination of 3D printing, biomaterials blending and stem cell technology, offers the potential to establish customized, transplantable autologous implants using patient's own cells. Graphene, as two-dimensional (2D) version carbon, has shown great for tissue engineering. Here, we describe novel graphene with printed alginate (Alg)-based scaffolds human adipose (ADSC) support osteogenic induction. Alg printing was enabled through addition gelatin (Gel) that...