A5061486241- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Pain Mechanisms and Treatments
- Plant-Microbe Interactions and Immunity
- Orthopedic Surgery and Rehabilitation
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Optical Imaging and Spectroscopy Techniques
- Plant Disease Management Techniques
- Anesthesia and Pain Management
- Plant Pathogens and Fungal Diseases
- MicroRNA in disease regulation
- Foot and Ankle Surgery
- Nerve injury and regeneration
- Tuberculosis Research and Epidemiology
- Traditional Chinese Medicine Studies
- Medical Imaging Techniques and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Nausea and vomiting management
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Multiple Myeloma Research and Treatments
- EEG and Brain-Computer Interfaces
- Tracheal and airway disorders
Huazhong University of Science and Technology
2025
Southern University of Science and Technology
2024-2025
Soochow University
2024
Second Affiliated Hospital of Soochow University
2024
Dalian Medical University
2016-2024
Chongqing Medical University
2023-2024
Central South University
2014-2024
Anhui Medical University
2008-2024
First Affiliated Hospital of Anhui Medical University
2008-2024
Second Affiliated Hospital of Chongqing Medical University
2023-2024
The neuroprotective role of propofol (PPF) in cerebral ischemia-reperfusion (I/R) has recently been highlighted. This study aimed to explore whether the mechanisms PPF were linked its regulation Ca2+/CaMKKβ (calmodulin-dependent protein kinase β)/AMPK (AMP-activated kinase)/mTOR (mammalian target rapamycin)/autophagy pathway. Cultured primary rat cortical neurons treated with oxygen-glucose deprivation and re-oxygenation (OGD/R) mimic I/R injury vitro. Compared control neurons, OGD/R...
Intraneuronal neurofibrillary tangles composed of Tau aggregates have been widely accepted as an important pathological hallmark Alzheimer's disease. A current therapeutic avenue for treating disease is aimed at inhibiting accumulation with small molecules such natural flavonoids. Liquid-liquid phase separation (LLPS) can lead to its aggregation, and then be degraded by autophagy. However, it unclear whether flavonoids modulate the formation phase-separated droplets or promote autophagy...
Double-lumen endotracheal tubes and bronchial blockers allow lung isolation for one-lung ventilation. Few studies, however, directly compare these devices. Further, a new endobronchial blocker (Coopdech) is available in some countries. Our primary hypothesis was that would be associated with less sore throat or hoarse voice than double-lumen tubes. Secondary outcomes were successful ventilation surgical access. In this prospective trial, 120 Chinese patients undergoing elective surgery...
Morphine tolerance is a challenging clinical problem that limits its application in pain treatment. Non-coding microRNAs (miRNAs) modulate gene expression post transcriptional manner, and their dysregulation causes various diseases. However, the significance of miRNAs morphine still poorly understood. In present study, we hypothesized microRNA-365 (miR-365) key functional small RNA reverses through regulation β-arrestin 2 rats. Here, microarray analysis quantitative real-time PCR showed...
In this study, volatile organic compounds (VOCs) were generated by Pseudomonas fluorescens ZX with incubation in nutrient broth (NB), on NA (NB agar), and healthy orange fruits, pure individual components of VOCs used to manage citrus green mold infected Penicillium digitatum. At a concentration 1 × 1010 cfu/mL, the from antagonist-containing plates inhibited P. digitatum conidial germination mycelial growth about 60%, while bacterial fluid exhibited approximately 75% inhibitory effect....
Glioblastoma stem cells (GSCs) reside in hypoxic periarteriolar niches of glioblastoma micro-environment, however, the crosstalk GSCs with macrophages on regulating tumor angiogenesis and progression are not fully elucidated. GSCs-derived exosomes (GSCs-exos) essential mediators during immune-microenvironment remodeling initiated by GSCs, resulting M2 polarization tumor-associated (TAMs) as we reported previously. Our data disclosed aberrant upregulation miR-374b-3p both clinical specimens...
This study describes the first report of application Metschnikowia pulcherrima combined with Saccharomyces cerevisiae to ferment plum wine. Variable factors studied include inoculum ratio (M. pulcherrima: S. = 10:1, 1:1, and 1:10), as well simultaneous versus sequential inoculation, tested trials spanning 10:1sim, 1:1sim, 1:10sim, 10:1seq, 1:1seq, 1:10seq, respectively. The yeast growth kinetics, physicochemical characteristics, organic acids, aroma profiles, sensory evaluation were...
Study Design. Basic science study using a hemi-section spinal cord injury (SCI) model. Objective. We sought to assess the effect of blocking Osteopontin (OPN) up-regulation on motor function recovery and pain behavior after SCI further investigate possible downstream target OPN in injured cord. Summary Background Data. is noncollagenous extracellular matrix protein widely expressed across different tissues. Its expression substantially increases following SCI. A previous suggested that this...
Background Neonatal exposure to isoflurane may induce long-term memory impairment in mice. Histone acetylation is an important form of chromatin modification that regulates the transcription genes required for formation. This study investigated whether neonatal exposure-induced neurocognitive related dysregulated histone hippocampus and it can be attenuated by deacetylase (HDAC) inhibitor trichostatin A (TSA). Methods C57BL/6 mice were exposed 0.75% three times (each 4 h) at postnatal days...
Purpose: Ischemic stroke recurrence (ISR) is prevented by inhibiting platelet function.To investigate the impact of high on-treatment reactivity (HTPR) assessed thromboelastography (TEG) and its risk factors on ISR in individuals who have experienced acute ischemic (AIS) receiving dual anti-platelet therapy (DAPT).Patients Methods: At end follow-up, a total 264 patients met criteria were enrolled this cohort study.The primary endpoint event was within 90 days onset.Results: The rate 7.2%...
Bone cancer pain (BCP) is the most common complication in patients with bone cancer. Glial cell line-derived neurotrophic factor (GDNF) believed to be involved chronic conditions. In this article, expression and roles of GDNF were studied a rat model BCP induced by tibia injection Walker 256 mammary gland carcinoma cells. Significant mechanical thermal hyperalgesia ongoing observed beginning as early day 5 post injection. The level protein examined on 16 after was decreased L3 dorsal root...
The incidence of Non-alcoholic fatty liver disease (NAFLD) in China and USA is extremely high rising. TikTok has become a popular channel for medical information dissemination we aimed to evaluate the quality reliability NAFLD related videos on TikTok, both its Chinese versions. We analyzed top 100 version total 200 videos, from which keywords were extracted scored using Global Quality Scale (GQS), modified DISCERN (mDISCERN), Medical Video Evaluation Tool (MQ-VET). Exploring relationship...
Intraneuronal accumulation of hyperphosphorylated tau is a hallmark Alzheimer's disease (AD). Given the significant correlation between pathology and memory loss in AD patients, identifying vulnerable brain regions, particularly susceptible neuron types these will advance our understanding onset shed light on therapeutic strategies to manage its progression. Immunofluorescent staining was employed identify regions AD. A combination chemogenetics, electrophysiological recording, vivo Ca2+...
This study aimed to retrospectively review the clinical efficacy of open reduction and internal fixation (ORIF) for treatment high-energy transsyndesmotic ankle fracture dislocation-the "Logsplitter" injury.Between December 2006 2014, 41 patients (29 males 12 females; mean age, 41.46 ± 13.42 years) with Logsplitter injury were treated by ORIF procedure. Patients grouped as typical (mainly vertical axial stress) untypical rotational according mechanism degree talus wedged into distal...
Although calcitonin gene-related peptide is a recognized pain transducer, the expression of in primary afferents may be differentially affected following different types nerve injury. Here, we examined whether patterns contributes to distinct sensory disturbances three animal models sciatic injury: chronic constriction injury, mild (100 g force) or strong (1000 transient crush rats. Assessments withdrawal reflexes and spontaneous behavior indicated that injury resulted positive neuropathic...