A5101397597- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Sarcoma Diagnosis and Treatment
- Shoulder Injury and Treatment
- Elbow and Forearm Trauma Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Eosinophilic Disorders and Syndromes
- Acute Lymphoblastic Leukemia research
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- Aldose Reductase and Taurine
- Cancer-related gene regulation
- Uterine Myomas and Treatments
- Shoulder and Clavicle Injuries
- IL-33, ST2, and ILC Pathways
- Cancer, Hypoxia, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Lymphoma Diagnosis and Treatment
- Diet and metabolism studies
- NF-κB Signaling Pathways
- Wnt/β-catenin signaling in development and cancer
Qingdao University
2025
Affiliated Hospital of Qingdao University
2025
Jinan University
2024
West China Medical Center of Sichuan University
2024
Affiliated Hospital of Chengde Medical College
2018-2023
Wenzhou Medical University
2014-2023
Chengde Medical University
2023
China Medical University
2017-2020
University of Massachusetts Amherst
2017-2018
Novartis (United States)
2008-2018
Background: Treatment-free remission (TFR)—that is, stopping tyrosine kinase inhibitor (TKI) therapy without loss of response—is an emerging treatment goal in chronic myeloid leukemia (CML). Objective: To evaluate TFR after discontinuation second-line nilotinib therapy. Design: Single-group, phase 2, open-label study. (ClinicalTrials.gov: NCT01698905) Setting: 63 centers 18 countries. Patients: Adults with CML who received TKI for at least 3 years (>4 weeks imatinib, then ≥2 nilotinib) and...
Chronic hepatitis B virus (HBV) infection is epidemiologically associated with hepatocellular carcinoma (HCC), but its role in HCC remains poorly understood due to technological limitations. In this study, we systematically characterize HBV patients. sequences were enriched from 48 patients using an oligo-bead-based strategy, pooled together and sequenced the FLX-Genome-Sequencer. tumors, preferential integration of into promoters genes ( P < 0.001) significant enrichment chromosome 10 0.01)...
Pancreaticobiliary maljunction (PBM) is a rare cause of recurrent pancreatitis. During the past 10 years, treatment protocols for PBM have been progressively improved and revised; however, latest therapeutic strategies not comprehensively summarized in literatures. Herein, we present typical case PBM-related pancreatitis which highlights role pathogenesis prompts us to revisit optimize current PBM. A 59-year-old female patient was admitted hospital with abdominal pain, vomiting cessation...
Purpose . The aim of this study was to evaluate the effects high frequency repetitive transcranial magnetic stimulation (HF-rTMS) on stroke patients with motor dysfunction and investigate underlying neural mechanism. Methods Fifteen were assigned rTMS treatment (RT) group conventional (CT) group. Patients in RT received 10 Hz ipsilesional primary cortex for days plus CT, which consisted acupuncture antiplatelet aggregation medication. Difference fractional anisotropy (FA) between...
The major objective of the present study was to investigate effect imatinib on pharmacokinetics paracetamol in patients with chronic myelogenous leukaemia (CML).Patients (n = 12) received a single oral dose acetaminophen 1000 mg day 1 (control). On days 2-8, 400 administered daily. 8 (treatment), another h after morning mg. Blood and urine samples were collected for bioanalytical analyses.The area under plasma concentration-time curve (AUC) paracetamol, glucuronide sulphate control...
The Evaluating Nilotinib Efficacy and Safety in Clinical Trials-Extending Molecular Responses (ENESTxtnd) study was conducted to evaluate the kinetics of molecular response nilotinib patients with newly diagnosed chronic myeloid leukaemia phase impact novel dose-optimization strategies on patient outcomes. ENESTxtnd protocol allowed dose escalation (from 300 400 mg twice daily) case suboptimal or treatment failure as well re-escalation for reductions due adverse events. Among 421 enrolled...
7054 Background: The ENESTop (NCT01698905) study explores the discontinuation of NIL therapy in pts who achieved sustained MR4.5 (BCR-ABL1IS≤ 0.0032%) after switching from imatinib (IM) to NIL. Methods: single-arm phase 2 enrolled with CML-CP treated tyrosine kinase inhibitor (TKI) for ≥ 3 y (including IM > 4 wk followed by y) and on On study, continued 1 (consolidation [CONS]). After y, without confirmed loss (consecutive BCR-ABL1IS 0.0032%), were eligible stop (TFR). RQ-PCR was monitored...
Autophagy-related long non-coding RNAs (arlncRNAs) play a crucial role in the pathogenesis and development of tumor. However, there is lack systematic analysis arlncRNAs melanoma patients.Melanoma data for were obtained from The Cancer Genome Atlas (TCGA) database. By establishing co-expression network autophagy-related mRNAs-lncRNAs, we identified patients. We evaluated prognostic value by univariate multivariate Cox constructed an risk model. Patients divided into high- low-risk groups...
The previous study shows that obesity-promoted inflammation is responsible for the activation of intestinal tumorigenic Wnt-signaling. present aims to test a dietary strategy, supplementation with high dose vitamin D (VD) or its combination sulforaphane (SFN) inhibit and obesity-associated tumorigenesis.Apc1638N mice are randomly divided into four groups: LF, low-fat diet (10 kcal% fat) 200 IU VD; HF, high-fat (60 HFD, 5000 HFDS, plus VD 0.23 g SFN per ≈4000 kcal. administration decreased...
Abstract The long‐term incidence trends of 32 cancers in China remained unclear. Cancer statistics for young population were often presented aggregate, masking important heterogeneity. We aimed to assess the from 1983 2032, stratified by sex and age groups. Data on cancer 2017 extracted Incidence Five Continents Volumes VI–XII. age‐period‐cohort model was utilized birth cohort effects temporal China, while Bayesian project future 2018 2032. An increase is observed some such as thyroid kidney...
Background: This study sought to assess the prognostic factors for leiomyosarcoma (LMS) patients with lung metastasis and construct web-based nomograms predict overall survival (OS) cancer-specific (CSS).Method: Patients diagnosed LMS combined between 2010 2016 were identified in Surveillance, Epidemiology, End Results (SEER) database. The randomly divided into a training set testing set. X-tile analysis provides best age tumor size cut-off point, changes continuous variables categorical...
The purpose of this study was to examine the cross-sectional associations between dietary glycemic index (GI) and load (GL) cardiovascular disease (CVD) risk factors in Chinese children. A total 234 schoolchildren aged 8-11 years Guangdong participated study. Dietary intake assessed via a 3-day record. Seven established indicators were analyzed study: fasting plasma glucose (FPG), triglycerides (TG), cholesterol (TC), high-density lipoprotein (HDL-C), low-density (LDL-C), systolic blood...
Objective: To investigate the inhibitory effect of AKR1B10 inhibitor combined with sorafenib on hepatocellular carcinoma (HCC) xenograft growth. Methods: HepG2 model was established in nude mice. The mice were then randomly divided into four groups: control group, epalrestat monotherapy group and combination treatment group. Tumor volume, tumor weight, T/C ratio change body weight each compared to evaluate curative effect. Immunohistochemistry staining used detect expression Ki-67 tissues...
Abstract Objective The standard surgical treatment for supracondylar humeral fractures in children is closed reduction and percutaneous pinning. Given the need greater fixation strength higher risk of joint stiffness older than 8 years, external often performed treating children. aim this study was to compare efficacy lateral entry pins Slongo’s Methods Children years who underwent surgery at our hospital from January 2016 December 2020 are be retrospectively assessed. One group (n = 36)...
Studies have shown that the RNA N6-methyladenosine (m6A) modification patterns are extensively involved in development of multiple tumors. However, association between m6A regulator expression and sarcoma tumor immune microenvironment (TIME) remains unclear.We systematically evaluated patients with based on known 23 regulators. Different were analyzed using gene set variation analysis a single-sample enrichment algorithm. According to results consensus clustering, we classified into four...