A5023506504- Physiological and biochemical adaptations
- Aquaculture Nutrition and Growth
- Muscle Physiology and Disorders
- Fish Ecology and Management Studies
- Meat and Animal Product Quality
- Biomimetic flight and propulsion mechanisms
- Cardiomyopathy and Myosin Studies
- Adipose Tissue and Metabolism
- Animal Genetics and Reproduction
- Neurobiology and Insect Physiology Research
- Sports Performance and Training
- Fish biology, ecology, and behavior
- Muscle activation and electromyography studies
- Reproductive biology and impacts on aquatic species
- Aquaculture disease management and microbiota
- Ichthyology and Marine Biology
- Marine Bivalve and Aquaculture Studies
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- High Altitude and Hypoxia
- Marine and fisheries research
- Congenital heart defects research
- Cardiovascular and exercise physiology
- Animal Behavior and Reproduction
- Muscle metabolism and nutrition
University of St Andrews
2011-2022
Wellcome Sanger Institute
2022
Genomics (United Kingdom)
2022
University of Oxford
2021
Centre for Human Genetics
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
King's College London
2021
Horizon Discovery (United Kingdom)
2019-2020
Sands
1993-2010
The University of Sydney
2007
Whole genome duplication (WGD) is often considered to be mechanistically associated with species diversification. Such ideas have been anecdotally attached a WGD at the stem of salmonid fish family, but remain untested. Here, we characterized an extensive set gene paralogues retained from WGD, in covering major lineages (subfamilies Salmoninae, Thymallinae and Coregoninae). By combining data calibrated relaxed molecular clock analyses, provide first well-constrained direct estimate for...
Global warming is intensifying interest in the mechanisms enabling ectothermic animals to adjust physiological performance and cope with temperature change. Here we show that embryonic can have dramatic persistent effects on thermal acclimation capacity at multiple levels of biological organization. Zebrafish embryos were incubated until hatching control ( T E = 27 °C) or near extremes for normal development 22 °C 32 then raised adulthood under common conditions °C. Short-term challenge...
The abundance, distribution and oxidative capacities of mitochondria have been investigated in the red pectoral fin adductor muscles fish (Order Perciformes) that use a predominantly labriform style swimming. Mediterranean Sea species from families Labridae, Serranidae, Sparidae Antarctic Nototheniidae non-Antarctic Channichthyidae were studied. Sub-Antarctic Beagle Channel, Tierra del Fuego, included pelagic haemoglobin-less icefish (Champsocephalus esox) robalo (Eleginops maclovinus),...
Abstract Enhanced production of high quality and healthy fry is a key target for successful competitive expansion the aquaculture industry. Although large quantities fish larvae are produced, survival rates often low or highly variable growth potential in most cases not fully exploited, indicating significant gaps our knowledge concerning optimal nutritional culture conditions. Understanding mechanisms that control early development muscle critical identification time windows introduce...
Hearts from 16 species of fishes, including representatives cyclostomes, elasmobranchs, and teleosts, were examined. As a biochemical index maximal ATP demand, ATPase activity crude homogenates ventricular tissue was measured under conditions which optimize myofibrils inhibit nonphysiological mitochondrial F₁-ATPase by inclusion oligomycin in the assay medium. The activities nine additional enzymes pathways energy metabolism concentration myoglobin-an intracellular protein involved storage...
SUMMARY We investigated the effects of embryonic temperature (ET) treatments (22,26 and 31°C) on life-time recruitment fast myotomal muscle fibres in zebrafish Danio rerio L. reared at 26/27°C from hatching. Fast were produced until 25 mm total length (TL) 22°C ET, 28 TL 26°C ET 23 31°C ET. The final fibre number (FFN)showed an optimum (3600) was 19% 14% higher than for (3000) (3100) treatments, respectively. Further growth to maximum ∼48 only involved hypertrophy. Microarray experiments...
ABSTRACT The differentiation of myotomal muscles in the brook trout (Salvelinus fontinalis Mitchill) has been investigated using p-phenylene diamine stained semi-thin sections and cytochemical quantitative determinations enzyme activities. Evidence is presented that range fibre size white muscle represents stages growth rather than distinct types. Electromyography shows both red are recruited for sustained swimming. threshold swimming speed recruitment fibres around 1·8 body length/s (L/s)....
In this study we describe the complete coding sequence for insulin-like growth factor I (IGF-I), II (IGF-II), binding protein (IGFBP) 1, 2, 4, 5 and 6 IGFBP-related 1 (IGFBP-rP1) of Atlantic salmon (Salmo salar L.). We also report characterisation two gene paralogues IGFBP-2 IGFBP-5. Following 22 days restricted feeding (0 d) to achieve zero growth, fish were fed satiation sampled at 3, 5, 7, 14, 30 60 days. Expression profiles genes involved in IGF signalling pathway fast myotomal muscle...
A technique for the demonstration of myofibrillar adenosine triphosphatase activity (ATPase) used mammalian muscle has been modified to suit fish muscle. The method involves selectively inhibiting fiber types by preincubation at either alkaline (pH 10.4) or acid 4.3) pH before incubation activity. Fish fibers were found be generally inactivated under these conditions. Preincubation an was unsuitable because indiscriminate inactivation fibers. effects preincubating 10.4 and incubating tissue...
Whole-genome duplication (WGD) was experienced twice by the vertebrate ancestor (2 rounds; 2R), again teleost fish (3R) and most recently in certain lineages (4R). Consequently, gene families are often expanded 3R 4R genomes. Arguably, many types of "functional divergence" present across 2R will exceed that between 3R/4R paralogs genes comprising families. Accordingly, offers a form replication 2R. Examining whether this concept has implications for molecular evolutionary research, we...
Structural variants (SVs) are a major source of genetic and phenotypic variation, but remain challenging to accurately type hence poorly characterized in most species. We present an approach for reliable SV discovery non-model species using whole genome sequencing report 15,483 high-confidence SVs 492 Atlantic salmon (Salmo salar L.) sampled from broad phylogeographic distribution. These recover population structure with high resolution, include active DNA transposon, widely affect...
Genomics is increasingly applied in breeding programmes for farmed fish and shellfish species around the world. However, current applications do not include information on genome functional activity, which can enhance opportunities to predict relationships between genotypes phenotypes hence increase accuracy of selection. Here, we review prospects improving aquaculture practises through uptake genomics data light EU Horizon 2020 project AQUA-FAANG: ‘Advancing European Aquaculture by Genome...