A5058143003- Alcohol Consumption and Health Effects
- Hematopoietic Stem Cell Transplantation
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Fibroblast Growth Factor Research
- Clinical Nutrition and Gastroenterology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Metabolism and Genetic Disorders
- Blood disorders and treatments
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Organ Transplantation Techniques and Outcomes
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- Eicosanoids and Hypertension Pharmacology
- Neutropenia and Cancer Infections
- Medical Imaging and Pathology Studies
- Kruppel-like factors research
- Lipid metabolism and disorders
- Adipose Tissue and Metabolism
Case Western Reserve University
2019-2022
Northeast Ohio Medical University
2015-2019
Pharmaceutical Biotechnology (Czechia)
2017
Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine
2017
Shanghai University of Traditional Chinese Medicine
2017
Matrix Research (United States)
2016
Lipin-1 is a Mg2+-dependent phosphatidic acid phosphohydrolase involved in the generation of diacylglycerol during synthesis phospholipids and triglycerides. Ethanol-mediated inhibitory effects on adipose-specific lipin-1 expression were associated with experimental steatohepatitis rodents. In present study, using an overexpression transgenic (Lpin1-Tg) mouse model, we tested hypothesis that mice might dampen ethanol-induced liver damage. Experimental alcoholic was induced by pair-feeding...
Ethanol-mediated injury, combined with gut-derived lipopolysaccharide (LPS), provokes generation of proinflammatory cytokines in Kupffer cells, causing hepatic inflammation. Among the mediators these effects, miR-217 aggravates ethanol-induced steatosis hepatocytes. However, role liver inflammation process is unknown. Here, we examined responses to ethanol, LPS, or a combination ethanol and LPS RAW 264.7 macrophages primary cells. In macrophages, substantially exacerbated LPS-mediated...
MitoNEET (mNT) (CDGSH iron-sulfur domain-containing protein 1 or CISD1) is an outer mitochondrial membrane that donates 2Fe-2S clusters to apo-acceptor proteins. In the present study, using a global mNT knock-out (mNTKO) mouse model, we investigated in vivo functional role of development alcoholic steatohepatitis. Experimental steatohepatitis was achieved by pair feeding wild-type (WT) and mNTKO mice with Lieber-DeCarli ethanol-containing diets for 4 weeks. Strikingly, chronically...
Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by interstitial remodeling and dysfunction. The etiology of IPF not completely understood but involves pathologic inflammation subsequent failure to resolve in response epithelial injury. Treatments for are limited anti-inflammatory immunomodulatory agents, which only partially effective. Prostaglandin E2 (PGE2) disrupts TGFβ signaling suppresses myofibroblast differentiation, however practical strategies...
Abstract Lipin-1 is a phosphatidate phosphohydrolase (PAP) required for the generation of diacylglycerol during glycerolipid synthesis, and exhibits dual functions in regulation lipid metabolism. has been implicated pathogenesis alcoholic liver disease (ALD). In present study, we assessed lipin-1 function myeloid cells ALD using cell-specific knockout (mLipin-1KO) mouse model. Utilizing Gao-binge ethanol feeding protocol, matched mLipin-1KO mice littermate loxP control (WT) were pair-fed...
The splenic microenvironment regulates hematopoietic stem and progenitor cell (HSPC) function, particularly during demand-adapted hematopoiesis; however, practical strategies to enhance support of transplanted HSPCs have proved elusive. We previously demonstrated that inhibiting 15-hydroxyprostaglandin dehydrogenase (15-PGDH), using the small molecule (+)SW033291 (PGDHi), increases BM prostaglandin E2 (PGE2) levels, expands HSPC numbers, accelerates hematologic reconstitution after...
Aplastic anemia (AA) is a human immune-mediated bone marrow failure syndrome that treated by stem cell transplantation for patients who have matched related donor and immunosuppressive therapy (IST) those do not. Responses to IST are variable, with still at risk prolonged neutropenia, transfusion dependence, immune suppression, severe opportunistic infections. Therefore, additional therapies needed accelerate hematologic recovery in receiving front-line IST. We shown inhibiting...
Emerging evidence implicates the eicosanoid molecule prostaglandin E2 (PGE2) in conferring a regenerative phenotype to multiple organ systems following tissue injury. As aging is part characterized by loss of stem cells’ capacity, we tested hypothesis that prostaglandin-degrading enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH) contributes diminished fitness aged mice. Here demonstrate genetic 15-PGDH ( Hpgd ) confers protective effect on murine hematopoietic and gastrointestinal (GI)...
Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by interstitial remodeling and dysfunction. The etiology of IPF not completely understood but involves pathologic inflammation subsequent failure to resolve in response epithelial injury. Therapeutic strategies for are limited anti-inflammatory immunomodulatory agents, which only partially effective. Prostaglandin E2 (PGE2) disrupts TGFβ signaling suppresses myofibroblast differentiation, however practical...
Aplastic anemia (AA) is a human immune mediated bone-marrow failure syndrome that treated by stem cell transplantation for patients who have matched related donor or immunosuppressive therapy (IST) those do not. Responses to IST are variable, with still at risk prolonged neutropenia, transfusion-dependence, suppression, and severe opportunistic infections. Therefore, additional therapies accelerate hematologic recovery in receiving front line needed. We shown inhibiting...
Abstract The splenic microenvironment regulates hematopoietic stem and progenitor cell (HSPC) function, particularly during demand-adapted hematopoiesis, however practical strategies to enhance support of transplanted HSPCs have proven elusive. We previously demonstrated that inhibiting 15-hydroxyprostaglandin dehydrogenase (15-PGDH), using the small molecule (+)SW033291 (PGDHi), increases bone marrow (BM) prostaglandin E2 (PGE2) levels, expands HSPC numbers, accelerates hematologic...
Elevated triglycerides (TGs) are an independent risk factor for cardiovascular disease (CVD). Lipoprotein lipase (LPL) found along the capillary endothelium catalyzes hydrolysis of TG rich lipoproteins and chylomicrons. Angiopoietin-like (ANGPTL) proteins including ANGPTL3 have been identified as endogenous inhibitors LPL. As a result, overexpression is associated with elevated TGs increased CVD. Excessive alcohol intake secondary hypertriglyceridemia may worsen seen in primary lipid...
ABSTRACT Emerging evidence implicates the eicosanoid molecule prostaglandin E2 (PGE2) in conferring a regenerative phenotype to multiple organ systems following tissue injury. As aging is part characterized by loss of stem cells’ capacity, we tested hypothesis that prostaglandin-degrading enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH) contributes diminished fitness aged mice. Here demonstrate genetic 15-PGDH ( Hpgd ) confers protective effect on murine hematopoietic and...