A5103223954- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Virus-based gene therapy research
- Pelvic and Acetabular Injuries
- Colorectal Cancer Treatments and Studies
- Animal Genetics and Reproduction
- Cell Adhesion Molecules Research
- Herpesvirus Infections and Treatments
- Immunodeficiency and Autoimmune Disorders
- CRISPR and Genetic Engineering
- interferon and immune responses
- Medical Imaging and Analysis
- Colorectal and Anal Carcinomas
- Ocular Diseases and Behçet’s Syndrome
- Pleural and Pulmonary Diseases
- Genomics and Rare Diseases
- Neonatal Respiratory Health Research
- Intestinal Malrotation and Obstruction Disorders
- Vector-Borne Animal Diseases
- Infant Nutrition and Health
- Toxin Mechanisms and Immunotoxins
- Pluripotent Stem Cells Research
Texas Health Dallas
2021-2022
Columbia University Irving Medical Center
2018-2022
Weill Cornell Medicine
2022
Neurological Surgery
2022
Cornell University
2022
The Spine Institute
2021
Columbia University
2021
Loyola University Chicago
2021
University of Nevada, Reno
2004-2018
Yonsei University
2014
Transcriptome-scale data can reveal essential clues into understanding the underlying molecular mechanisms behind specific cellular functions and biological processes. Transcriptomics is a continually growing field of research utilized in biomarker discovery. The transcriptomic profile interstitial cells Cajal (ICC), which serve as slow-wave electrical pacemakers for gastrointestinal (GI) smooth muscle, has yet to be uncovered. Using copGFP-labeled ICC mice flow cytometry, we isolated...
Abstract: The "Kickstand-Rod" technique: new surgical procedure for correction of coronal imbalance (CI) in spinal deformity patients. Coronal plane is difficult to achieve and maintain. We developed the technique CI a safe effective method
Platelet-derived growth factor receptor alpha (PDGFRα)+ cells are distributed into distinct morphological groups within the serosal, muscular, and submucosal layers as well myenteric deep muscular plexi. PDGFRα+ directly interact with interstitial of Cajal (ICC) smooth muscle (SMC) in gastrointestinal tissue. These three cell types, SMC, ICC, (SIP cells), form an electrical syncytium, which dynamically regulates motility. We have previously reported transcriptomes SMC ICC. To complete SIP...
The purpose of this study was to determine the incidence, mechanism, and potential protective strategies for pelvic fixation failure (PFF) within 2 years after adult spinal deformity (ASD) surgery.Data ASD patients (age ≥ 18 years, minimum six instrumented levels) with (S2-alar-iliac [S2AI] and/or iliac screws) a 2-year follow-up were consecutively collected (2015-2019). Patients prior excluded. PFF defined as any revision screws, which may include broken rods across lumbosacral junction...
The possibility of permanent genetic changes to the germline is central bioethics in utero gene therapy (IUGT) because concern inadvertent potentially deleterious alterations pool. Despite presumed protection male due early germ cell (GC) compartmentalization, we reported that GCs within developing ovine testes are transduced at low levels after retrovirus-mediated IUGT, thus underscoring need for a thorough understanding GC development clinically predictive models determine optimal time...
The direct vector injection approach was used in the fetal sheep model of utero gene therapy to determine effects recipient gestational age on efficacy and pattern liver, lung, brain transduction transgene expression. livers contained foci transgene-expressing hepatocytes demonstrated an inverse correlation between hepatocyte transduction/transgene expression, with higher levels transfer/expression early gestation lower late gestation. Conversely, percentage cells within lungs these same...
Multicenter cohort.To compare the robot time/screw, radiation exposure, abandonment, screw accuracy, and 90-day outcomes between robot-assisted percutaneous open approach for short lumbar fusion (1- 2-level).There is conflicting literature on superiority of minimally invasive spine surgery to techniques. A large, multicenter study needed further elucidate complications these two approaches.We included adult patients (≥18 yrs old) who underwent from 2015 2019 at four independent institutions....
Despite substantial premarket efforts, a significant portion of approved drugs has been withdrawn from the market for safety reasons. The deleterious impact nonsynonymous substitutions predicted by SIFT algorithm on structure and function drug-related proteins was evaluated 2504 personal genomes. Both (n = 154) precautionary (Beers criteria 90), US FDA pharmacogenomic biomarkers 96)) showed significantly lower genomic deleteriousness scores (P < 0.001) compared to others 752). Furthermore,...
Proximal junctional kyphosis (PJK) is a difficult complication to manage following adult spinal deformity surgery. Particularly in fusions from the lower thoracic spine down pelvis, PJK major consideration. While open posterior approach allows for excellent visualization and preparation of bony surfaces fusion, disruption soft tissue structures increases risk postoperatively. Minimally invasive approaches, on other hand, preserve ligamentous musculature at proximal fusion levels however...
ABSTRACT Ocular herpes simplex virus 1 (HSV-1) infection can lead to multiple complications, including iritis, an inflammation of the iris. Here, we use human iris stroma cells as a novel in vitro model demonstrate HSV-1 entry and inflammatory mediators that damage The upregulated cytokines observed this study provide new understanding intrinsic immune mechanisms contribute onset iritis.
Purpose: Retinal ischemia/reperfusion (I/R) injury is a common cause of visual impairment and blindness for which there remain limited treatment options. Nucleoside reverse transcriptase inhibitors (NRTIs), such as zidovudine (AZT), have been shown to block the NLRP3 inflammasome prevent retinal degeneration in mouse model age-related macular degeneration. The has also be triggered I/R injury. Therefore, we studied neuroprotective effects AZT using pressure-induced ischemia model. Methods:...
Significant investigation in the adult population has generated a body of research regarding proximal junctional kyphosis (PJK) and failure (PJF) following long fusions to sacrum pelvis. However, much less is known early complications, including PJK PJF, ambulatory pediatric patient. As such, objective this study was address minimal literature on complications after patients underwent fusion with instrumentation pelvis era sacral-alar-iliac (S2AI) instrumentation.
Intestinal obstructions, that impede or block peristaltic movement, can be caused by abdominal adhesions and most gastrointestinal (GI) diseases including tumorous growths. However, the cellular remodeling mechanisms involved in, by, intestinal obstructions are poorly understood. Several animal models of have been developed, but mouse model is cost/time effective. The uses surgical implantation an partial obstruction (PO) has a high mortality rate if it not performed correctly. In addition,...
To compare the patient-reported outcomes (PROs) between patients undergoing multilevel lumbar fusion with robot-assisted vs. freehand techniques. This was a single-institution cohort study of adult (≥18 years old) spine surgery from 2016 to 2018 minimum 2-year follow-up. A propensity-score matching (PSM) algorithm accounted for several perioperative factors. PROs were measured using Oswestry Disability Index (ODI). The clinically important difference (MCID) groups assessed at each follow-up...
Proximal junctional kyphosis (PJK) following surgical correction of adolescent idiopathic scoliosis (AIS) is a postoperative radiographic finding observed in the sagittal plane. Development PJK has not been shown to lead negative clinical outcome spinal fusion for AIS. Long-term satisfactory deformity surgery related status Proper understanding and prevention AIS needed preserve best plane